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Comparative evaluation of selected sex hormones in premenopausal and postmenopausal women with breast cancer

Research Paper | December 1, 2019

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Nadeem Ahmad, Saeeda Kalsoom, Zahed Mahmood, Muhammad Riaz, Imtiaz Mahmood Tahir, Akhtar Rasul, Haroon Ur Rashid, Syed Muhammad Ali Shah, Naveed Munir, Muhammad Akram

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Int. J. Biosci.15( 6), 16-25, December 2019

DOI: http://dx.doi.org/10.12692/ijb/15.6.16-25


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Breast cancer is the second most common cancer among women with respect to gender and manifold evidence support a vital role of hormones in the etiology of this cancer as sex steroids stimulate the development and proliferation of breast cells. The present study was planned to investigate the relationship of selective female sex hormones including estradiol, progesterone and testosterone in premenopausal and postmenopausal women with breast cancer from local areas of Punjab, Pakistan. Total 150 selected subjects divided into three main groups; control group (n=40) (premenopausal and postmenopausal) (n=20 each) not having breast disease or hormone related tumors or any other disease, 59 premenopausal patients and 51 postmenopausal patients having breast cancer. Pre and postmenopausal patients were divided further into three patient groups; a) newly diagnosed b) under treatment and c) treated. After evaluation, the blood hormone levels by Electro Chemi Luminescence immunoassay, one-way analysis of variance (ANOVA) and least significant difference (LSD) tests were used to evaluate results statistically. Results showed that non-significant relationship found between estradiol (p = 0.364), progesterone (p = 0.603), testosterone (p = 0.458) in premenopausal women and breast cancer. Significant relationship was found between estradiol (p < 0.05) and testosterone (p < 0.05) in postmenopausal females with breast cancer while progesterone showed non-significant association (p > 0.05) with breast cancer. The study concluded that serum estradiol and testosterone levels in postmenopausal women could be associated with breast cancer.


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