Comparative potential of Moringa oleifera and Bougainvillea spectabilis against pyrethrin (Deltamethrin) induced toxicity in albino rats

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Research Paper 01/09/2020
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Comparative potential of Moringa oleifera and Bougainvillea spectabilis against pyrethrin (Deltamethrin) induced toxicity in albino rats

Shahla Akash, Nazia Ehsan, Mehwish Malik, Noor Fatima, Muhammad Yaseen, Ayesha Saddique, Sadaf, Sadia Afsheen, Mahtab Ahmed
Int. J. Biosci.17( 3), 281-286, September 2020.
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Pesticidal induced toxicity proved to impose lethargic effects on mammalian hematological and serological parameters. Study was conducted to evaluate ameliorating potential of Bougainvillea spectabilis and Moringa oleifera against pyrethrin type-II induced toxicity in albino rats. Experiment carried out for 60 days by selecting 12 healthy male albino rats, in Animal House of Food Science and Technology department of Agriculture University Faisalabad, acclimatized for one week and kept under favorable condition at 23ºC ± 3ºC temperature. All of these rats divided into 4 groups. T0 taken as control group feed on simple diet and water receiving no chemicals and plant extract. T1 received daily dose of deltamethrin (1.55ml) bougainvillea spectabilis along with (150mg) per body weight orally, T2 received deltamethrin (1.56ml) along Moringa oleifera plant extract (150ml), T3 received deltamethrin only about 1.57ml. Each rat act as individual replica. Daily dosage of mixture was offered to all these groups. Autopsy of these rats done after considerable period to analyzed certain changes observed in weight, hematological parameters and serological parameters. RBC, MCV, WBC, HCT, HGB, MCH, MCHC, LYM, LYM% and serological parameters such as AST, ALT, ALP, TSP, urea and creatinine. Results were analyzed by using Anova and Tukey comparison test. Statistical analysis showed highly significant (P˂0.01) results of both anti-oxidant against pesticidal induced toxicity.


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