Comparison of liver function tests between different genotypes of HBV and HCV in non-responders of HBV-HCVCo-infected patients with healthy controls

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Research Paper 01/09/2018
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Comparison of liver function tests between different genotypes of HBV and HCV in non-responders of HBV-HCVCo-infected patients with healthy controls

Naveeda Manzoor, Kirn-e-Muneera, Muhammad Adnan S, Naseer Ahmed, Shazia Fatima
Int. J. Biosci.13( 3), 68-74, September 2018.
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Hepatitis B and C co-infection may leads to cirrhosis resulting in hepatocellular carcinoma with poorer survival rate. Pegylated interferon and ribavirin treatment is considered as gold standard. Despite of adequate treatment, some patients remained non-responders. Due to this reason, this study was designed to compare different parameters of liver function tests along with HBV- HCV genotyping in non-responders of HBV-HCV co-infection with normal controls. Study population was divided in two groups. Group A (patient group) includes 30 HBV-HCV co-infected patients and Group B (control group).includes 30 normal individuals. Blood samples of both groups were collected. Samples were analyzed for HBV and HCV genotyping using automated kits of Abbott laboratories and Liver Functions testing (ALT, ALP, Bilirubin, Albumin) using ROCHE COBAS-501 automated system. Statistical analysis using chi-square test for ordinal data and t-test for numerical data was used using p-value <0.05 as significant. In all patients, HCV genotype was ‘3’. Most were co-infected with HBV genotype B (73.3%) as compared to genotype C (26.6%). Male to female ratio was about 1:1.1 in control group as compared to 6.5:1 in patients group. Mean age of controls was younger (32.3±6.8 years) as compared to patients (36.85±9.6 years).Overall, liver function tests were significantly high in patients group (p-value <0.05) as compared to controls. However, albumin and alkaline phosphatase levels show insignificant difference in HBV Genotype B and C patients. In conclusion, HBV-HCV co-infected patients have higher mean age, mean values of different parameters of liver function tests were significantly high in patient group as compared to control group.


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