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Comparison of serum C reactive protein in middle-aged smoker and non-smokers males

Research Paper | March 1, 2013

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Behbudi Laleh, Kaboli Mohamadzaman, Jafari Talat, Ferizadeh Abbas

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Int. J. Biosci.3( 3), 164-169, March 2013

DOI: http://dx.doi.org/10.12692/ijb/3.3.164-169


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The objective of present study was to compare serum C Reactive Protein (CRP) between smoker and none-smoker men. For this purpose, venous blood samples were collected after a overnight fast in order to measuring serum CRP in eighteen middle-aged non-trained males and eighteen none-smoker males matched for age (42.8 ± 8.3 years of old) and BMI (30.63 ± 3.3 kg/m2) participated in this study by accidentally samples. Independent sample T-test was used to compare the serum levels of CRP between two groups. Serum level of CRP was significantly higher in smoker group when compared with non-smoker subjects (median 2131 ± 211 Vs 1670 ± 313 ng/dl; P value = 0.021). Based on this data, we can point to the presence of systemic inflammation in smokers that is also associated with airway inflammation in these subjects probably.


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Comparison of serum C reactive protein in middle-aged smoker and non-smokers males

Bermudez EA, Rafai N, Buring JE. 2002. Relation between markers of systemic vascular inflammation and smoking in women. American Journal of Cardiology 89, 1117–1119.

Black S, Kushner I, Samols D. 2004. C-reactive protein. Journal of Biological Chemistry 279, 48487– 90.

Boshtam M, Abbaszadeh M, Rafiei M, Hahparian M, Boshtam M. 2006. Comparison of serum levels of CRP and uric acid in active, passive, and non-smokers. Arya Atherosclerosis Journal 2(1), 1 -6.

Boyle P. 1997. Cancer, cigarette smoking and premature death in Europe: a review including the Recommendations of European Cancer Experts Consensus Meeting, Helsinki, October 1996. Lung Cancer 17, 1–60.

Calabro P, Chang DW, Willerson JT. 2005. Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. Journal of the American College of Cardiology 46, 1112–3.

Casas JP, Shah T, Hingorani AD. 2008. C-reactive protein and coronary heart disease: a critical review. Journal of Internal Medicine 264, 295–314.

Crofton J, Bjartveit K. 1989. Smoking as a risk factor for chronic airways disease. Chest 96 (3 suppl), 307S–312S.

Danesh J, Whincup P, Walker M. 2000. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. British Medical Journal 2000 321, 199–204.

Dilyara G. Yanbaeva, Mieke A. Dentener, Eva C. 1999. Systemic Effects of Smoking. Central Coast Chest 3, 1557-1566.

Du Clos, Terry W. 2000. Functions of C- reactive protein. Annals of Internal Medicine 32, 274-278.

Eizadia M, Khorshidi D, Dooaly H, Samarikhalaj H. 2011. Circulating adiponectin regulates serum C – reactive protein and Interleukine-6 in obesity. Journal of Biodiversity and Environmental Sciences 1(5), 89-96.

Eizadib M, Sedaghati S, Khorshidi D, Dooaly H. 2011. Serum leptin and interleukin-6 in obese asthmatic patients affect by adiposity level not by the presence of asthma. International Journal of Review in Life Sciences 1(4), 229-234.

Fernández-Real JM, Ricart W. 2003. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocrine Reviews 24, 278-301.

Frohlich M, Sund M, Frolich M. 2003. Independent association of various smoking characteristics with markers of systemic inflammation in men: results from a representative sample of the general population (MONICA Augsburg Survey 1994/95). European Heart Journal 24, 1365– 1372.

Helmersson J, Larsson A, Vessby B. 2005. Active smoking and a history of smoking are associated with enhanced prostaglandin F, interleukin-6 and F2-isoprostane formation in elderly men. Atherosclerosis 181, 201–207.

Lowe GDO, Yarnell JWG, Rumley A. 2001. C-reactive protein, fibrin D-dimer, and incident ischemic heart disease in the speedwell study is inflammation and fibrin turnover linked in pathogenesis? Arterioscler Thrombosis Vascular Biology 21, 603–10.

Marreiro DN, Geloneze B, Tambascia MA, Lerário AC, Halpern A, Cozzolino SMF. 2004. Participação do zinco na resistência à insulina. Arquivos Brasileiros de Endocrinologia & Metabologia 48, 234-9. 13.

Merghani TH, Saeed A, Alawad A. 2012. Changes in plasma IL4, TNFá and CRP in response to regular passive smoking at home among healthy school children in Khartoum, Sudan. African Health Sciences 12(1), 41-47.

Ohsawa M, Okayama A, Nakamura M. 2005. CRP levels are elevated in smokers but unrelated to the number of cigarettes and are decreased by long-term smoking cessation in male smokers. Preventive Medicine 41, 651–6.

Ouchi N, Kihara S, Funahashi T. 2003. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107, 671–4.

Pepys MB, Hirschfield GM. 2003. C-reactive protein: a critical update. J Clin Invest 111, 1805–12.

Ridker PM, Haughie P. 1998. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98, 731–733.

Ronchetti R, Macri F, Ciofetta G, Indinnimeo L, Cutrera R, Bonci E, Antognoni G, Martinez FD. 1990. Increased serum IgE and increased prevalence of eosinophilia in 9 year old pupils of smoking parents. Journal of Allergy and Clinical Immunology 86 (1), 400-407.

Stienstra R, Duval C, Muller M, Kersten S. 2007. PPARs, obesity, and inflammation. Hindawi Publishing Corporation 3, 1-10.

Szmitko PE, Wang CH, Weisel RD. 2003. New markers of inflammation and endothelial cell activation: part I. Circulation 108, 1917–1923.

Tonstad S, Cowan JL. 2009. C-reactive protein as a predictor of disease in smokers and former smokers: a review. International Journal of Clinical Practice 63(11), 1634–1641.

Valença SS, Pimenta WA, Rueff-Barroso CR, Ferreira TS, Resende AC, Moura RS, Porto LC. 2009. Involvement of nitric oxide in acute lung inflammation induced by cigarette smoke in the mouse. Nitric Oxide Journal 20(3), 175 -181.

Van Eeden SF, Yeung A, Quinlam K. 2005. Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society 2, 61– 7.

Wannamethee SG, Lowe GD, Shaper AG. 2005. Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease. European Heart Journal 26, 1765–1773.

Wilkinson JD, Lee DJ, Arheart KL. 2007. Secondhand smoke exposure and C-reactive protein levels in youth. Nicotine & Tobacco Research 9, 305– 7.

Woodward M, Rumley A, Tunstall-Pedoe H. 1999. Associations of blood rheology and interleukin-6 with cardiovascular risk factors and prevalent cardiovascular disease. British Journal of Haematology 104, 246–257.

Yanbaeva DG, Dentener MA, Creutzberg EC. 2007. Systemic effects of smoking. Chest 131, 1557–66.

Yarnell JW, Sweetnam PM, Runley A. 2000. Lifestyle and hemostatic risk factors for ischemic heart disease: the Caerphilly Study. Arterioscler Thrombosis Vascular Biology 20, 271–279.