Comparison of three extracts of Fumeria indica for the evaluation of cytotoxic and phytotoxic activities

Paper Details

Research Paper 01/12/2012
Views (156) Download (2)
current_issue_feature_image
publication_file

Comparison of three extracts of Fumeria indica for the evaluation of cytotoxic and phytotoxic activities

Shambaleed Humayun, Muhammad Ibrar, Barkatullah, Imtiaz Ahmad
Int. J. Biosci.2( 12), 112-119, December 2012.
Certificate: IJB 2012 [Generate Certificate]

Abstract

In present work, the Fumeria indica was collected from University of Peshawar. The plant was shade dried and three extracts were prepared from the powder. The powder was used to observe under ultra violet light and by change in colour, has shown the presence of secondary metabolites with their derivatives. The extracts were used against phytochemical screening test, cytotoxic and phytotoxic activities. Phytochemical screening has shown the presence of carbohydrates, alkaloids, flavonoids, tannins, anthraquinones, saponin and starch. In cytotoxic activity, the n-hexane was found more effective than chloroform and ethanol but in phytotoxic activity the n-hexane was highly significant than ethanol whereas chloroform was found non-significant. Further experiments on Fumeria indica is needed to investigate its therapeutic properties.

VIEWS 1

Ali SI, Qaiser (Eds). 1993. Flora of Pakistan, Islamabad, Karachi.

Atta UR. 1991. Studies in Natural Product Chemistry,  Netherlands,  Elsevier  Science  Publiser 9,383-409.

Brindha  P,  Sasikala  B,  Puruslothman  KK. 1981. Pharmacognostic studies on Murugan kizhangu. Bull. Medic Ethen. Botanic Res 3, 84-96.

Camacho M R, Phillipson J D, Croft S L, Solis P N, Marshall S J, Ghazanfa S A. 2003: Screening of plant extracts for antiprotozal and cytotoxic activities. J. Ethnopharmacol 89, (2-3): 185-191.

Cherian S, Augustin KT. 1995. Insulin sparing action of leucopelargonidin derivative isolated from Ficus bengalesis Linn. Indian. J. Exp. Biol 33, 608-611.

Chew YL, Goh JK, Linn YY. 2009. Assessment in vitro antioxidant capacity and polyphenolic composition of selected medicinal herbs from leguminosae family in Peninsular Malaysia. Food. Chem 119, 373-378.

Erdogan TF. 2009. Brine shrimp lethality bioassay of Fumeria densiflora Dc and Fueria officinalis L. Etracts. Hacehepe University Journal of the faculty of Pharmacy 28(2), 125-132.

Evans WC. 1989. Trease and Evan’s Pharmacognosy. 13th Edn, Baillier Tindal, London.

Farrukh H, Ishfaq H, Ghulam D, Shams N, Ibrar K, Bashir A. 2010. Cytotoxicity and phytotoxicity of some selected medicinal plants of the family Polygonaceae. Afr. J. Biotechnol 9(5), 770-774.

Hussain J, Jamila N, Gilani SA, Abbas G, Ahmed S 2009. Platelet aggregation, antiglycation, cytotoxic, phytotoxic and antimicrobial activities of extracts of Nepeta juncea. African. J. Biotech 8(6), 935-940.

Khattak KF. 2012. Three microbiological quality assessment of commercially available medicinal plants in Peshawar city, Pakistan. Pak. J. Bot 44(4), 1203-1208.

Kirtikar KR, Basu BD. 1985. Indian Medicinal Plants. 3rd vol. In: Lalit Mohan Basu, editor. Allahabad p. 138.

Kokate CK. 1994. Practical Pharmacognosy. 4th Edn. Vallabh Prakashan, New delhi. P. 120-124.

Kokoshi CJ, Kokoshi RJ, Sharma PJ. 1958. Fluorescene of powdered vegetable drugs under UV radiation. J.  American Pharm. Asso 47, 715-717.

Laughlin MJL, Chang CJ, Smith DL. 1991. Bench-Top Bioassays the Discovery of Bioactive Natural Products: an update, Nat. Prod. Chem 9, 383-397

Naz I, Rrius JE, Saifullah, Blok V, Khan MR, Ali S. 2012. In vitro and in planta nematicidal activity of Fumeria parviflora (fumeriaceae) against the southern root-knot nematoda Meloidogyne incognitta. Plant Pathology 1(2), 365-371.

Nikolova M, Svetkova T R. 2007. Assessment of cytotoxic activity on alkaloid of amaryllidaceae and papaveraceae species. Serbia. 9, 211-214.

Orhan I, Sener B, Musharaf SG. 2010. Antioxidant and hypatoprotective activity appraisal of four selected Fumeria species and their total phenol and flavonoid quantities. Exp. Toxicol. Pathol (In press).

Pandey MAB, Abidi S, Singh RP. 2006. Nutritional evaluation of leafy vegetables. J. Hum. Ecol 19, 155-156.

Poorna CA, Maney SK, Santhoshkumar TR, Soniya EV. 2011. Phytochemical analysis and in vitro screening for biological activities of Acanthus ilicifolius. J. Pharm. Res 4(7), 1977-1981.

Samie A, Obi CL, Bessong PO, Namrita L. 2005. Activity profiles of fourteen selected medicinal plants from rural venda communities in south Africa against fifteen clinical bacterial species. African. J. Biotech 4(12), 1443-1451.

Shinwari MI, Khan MK. 1999. Folk use of medicinal herbs of Margalla Hills National Park, Islamabad. J. Ethnopharmacology 69, 45-56.

Sofowara EA. 1982. Medicinal plants and traditional medicines in Africa. John willey and Sons ltd, Nigeria 64-79.

Thenmozhi S, Sundaram RS, Kumar JP, Bihari CG. 2011. Pharmacognostical and phytochemical investigation on leaves of Vitex trifolia Linn. J. Pharmacy and Research 4(4), 1259-1262.

Trease E, Evans WC. 2002. Pharmacognosy 15th Edi. Harcourt Publishers Limited. p. 343-545.

Tyler, V. E., L. R. Brandy and J. E. Robbers. 1981. Pharmacognosy. Philadelphia: Lea and Febiger. p. 77–9.

Vass I, Sass L, Spetea C, Bakou A, Ghanotakis D, Petrouleas V. 1996. UV-B induced inhibition of photosystem II electron transport studiedby EPR and chlorophyll fluorescence. Impairment of donor and acceptor side components. Biochemistry 35, 8964–8973.

Yen GC, Duh PD, Tsai CL. 1996. Relationship between antioxidant activity and maturity of peanut hulls. J Agric Food Chem 41, 67-70.

Zabihullah Q, Rashid A, Akhtar N. 2006. Ethnobotanical survey in Kot manzaray baba valley Malakand agency, Pakistan. Pak. J. Pl. Sci 12(2),115-121.