Paper Details

Crosslinking of graft co-Polymerization alginate with acrylic acid for releasing drugs

Mohammad Sadeghi, Fatemeh Shafiei, Esmat Mohammadinasab, Mohammad Javad Khodabakhshi, Laleh Mansouri

DOI: https://dx.doi.org/10.12692/ijb/4.6.185-189

Int. J. Biosci. 4(6), 185-189. March, 2014. (PDF)

Abstract:

In this paper, synthesis and application of a novel alginate-based hydrogel as control releasing drug systems was investigated.The synthesized hydrogel exhibited a pH-responsiveness character so that a swelling-collapsing pulsatile behavior was recorded at pHs 1.2 and 7.4.This behavior makes the synthesized hydrogels as an excellent candidate for controlled delivery of bioactive agents.Therefore,Bovine serum albumin (BSA) as a model drug was loaded into the hydrogels by soaking the gels in a pH 7.4 and 1.2 buffer solution at 37°C(human body temperature).The drug was released gradually in the pH 7.4 buffer solution rather than in the pH 1.2.The release value of drug from hydrogels at pH 7.4 was higher than that at pH 1.2 due to the electrostatic repulsion between carboxylate groups.