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Research Paper | October 1, 2021

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Cytotoxic effect of ethanolic extract of Aloe castellorum on human breast carcinoma MCF-7 cells

Awad A. Algarni

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Int. J. Biosci.19(4), 162-165, October 2021

DOI: http://dx.doi.org/10.12692/ijb/19.4.162-165


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Cancer is the world’s most serious disease. New and safe anticarcinogens can be found in natural products. Aloe castellorum is an Aloe plant species native to Saudi Arabia. In the present study, the cytotoxic activity of the methanol extract of Aloe castellorum leaves was evaluated using breast adenocarcinoma cells (MCF-7), assessed by sulforhodamine B (SRB) cell viability assays. The results indicate that the Aloe castellorum showed weak cytotoxic effects against tested cancer cell lines, with an IC50 value of 341μg/ml. In conclusion, the in vitro cytotoxic evaluation of Aloe castellorum showed low cytotoxicity on MCF-7 cell line.


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Cytotoxic effect of ethanolic extract of Aloe castellorum on human breast carcinoma MCF-7 cells

Du Plessis LH, Hamman JH. 2014. In vitro evaluation of the cytotoxic and apoptogenic properties of aloe whole leaf and gel materials. Drug and chemical toxicology 37(2), 169-177. https://doi.org/10.3109/01480545.2013.834356

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer 136(5), E359-E386. https://doi.org/10.1002/ijc.29210

Fox LT, Mazumder A, Dwivedi A, Gerber M, Du Plessis J, Hamman JH. 2017. In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species. Journal of ethno pharmacology 200, 1-7. https://doi.org/10.1016/j.jep.2017.02.017

Gordaliza M. 2007. Natural products as leads to anticancer drugs. Clinical and Translational Oncology 9(12), 767-776. https://doi.org/10.1007/s12094-007-0138-9

Ibrahim EM, Zeeneldin AA, Sadiq BB, Ezzat AA. 2008. The present and the future of breast cancer burden in the Kingdom of Saudi Arabia. Medical Oncology 25(4), 387-393.  https://doi.org/10.1007/s12032-008-9051-5

Majumder R, Das CK, Mandal M. 2019. Lead bioactive compounds of Aloe vera as potential anticancer agent. Pharmacological research 148, 104416. https://doi.org/10.1016/j.phrs.2019.104416

Moharram BA, Al-Doaiss AA, Al-Mahbashi HM, Al-Kahtani MA, Alfaifi MA, Elbehairi SE, Saif-Ali R. 2020. Hepatoprotective, Antioxidant and Cytotoxic Potential of Aloe niebuhriana Latex Extract from Yemen. ndian Journal of Pharmaceutical Sciences 82(3), 514-521. https://doi.org/10.36468/pharmaceutical-sciences.675

Newman DJ, Cragg GM. 2012. Natural products as sources of new drugs over the 30 years from 1981 to 2010. Journal of natural products 75(3), 311-335. https://doi.org/10.1021/acs.jnatprod.5b01055