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Dengue virus localization in human tissues (case study)

M.W.D.M. Mihindukulasooriya, R.P.V.J. Rajapaksha, S.A.M. Kularatne

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Int. J. Biosci.3(10), 252-255, October 2013

DOI: http://dx.doi.org/10.12692/ijb/3.10.252-255


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Dengue is an arboviral disease which is present in tropical and subtropical regions of the world. Dengue virus (DENV) can cause benign dengue fever (DF) to the most severe forms, dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS). Many studies have been confirmed the dengue viral antigens in various types of naturally infected human tissues but little work has been done and is not certain the localization of viral RNA in human tissues. We studied tissue specimens of two patients who died from clinically diagnosed DHF to confirm serologically or virologically. DENV was detected by dengue specific Reverse transcription polymerase chain reaction (RT-PCR) for the detection of dengue viral RNA. From the RT-PCR, dengue viral RNA was detected in liver, kidney and lungs tissues while the DENV RNA absence in brain, heart, spleen and pancreas tissues. DENV can infect a number of different tissue types.


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Dengue virus localization in human tissues (case study)

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