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Detection of antibiotics cephtazidime and cephradine in hospital effluents and soil of Peshawar valley, Khyber Pakhtunkhwa province of Pakistan

Research Paper | November 1, 2015

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Akhtar Hassan, Muhammad Suleman, Aqleem Abbas, Nadia Khan, Muhammad Ilyas, Maria Ikhlas, Asma Akbar

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Int. J. Biosci.7( 5), 58-65, November 2015

DOI: http://dx.doi.org/10.12692/ijb/7.5.58-65


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The present study was carried out to detect the prevalence of antibiotics in the hospital effluents and soil of Peshawar valley, Khyber Pakhtunkhwa province of Pakistan. Two antibiotics were detected in the waste effluents, soil and drinking water of three hospitals including Hayatabad medical complex (HMC), Khyber teaching hospital (KTH) and Lady reading hospitals (LRH). The antibiotics included cephtazidime, (CPZM) and cephradine (CPDN). Samples collected from the selected locations were extracted by QuEChERS method technique followed by reversed phase high performance liquid chromatography. The results showed that the two selected antibiotics were detected in all the samples of HMC except CPZM which was not detected in the drinking water of HMC; however the waste water samples of HMC contained CPZM (0.47 µg mL-1) in highest concentration among all the samples. It was revealed that waste water and soil of KTH contained all the selected antibiotics in higher concentrations than other samples. The waste water samples of KTH contained CPDN (0.64 µg mL-1) in much higher concentration than other samples of KTH. The samples collected from LRH waste water contained the two selected antibiotics in higher concentration compared to other sites of LRH. CPDN (0.46µg mL-1) is in the higher amount in hospital waste water among all the LRH samples. The results revealed that the two selected antibiotics were present at relatively higher concentration in the waste water and soil samples than the other samples. Further studies based on the risk assessment required to investigate the impact of these contaminants on the soil microbial community, aquatic organisms and human beings.


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Detection of antibiotics cephtazidime and cephradine in hospital effluents and soil of Peshawar valley, Khyber Pakhtunkhwa province of Pakistan

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