Welcome to International Network for Natural Sciences | INNSpub

Development of model and subsequent kinetic study on photo-fenton degradation of 5-ethyl-5-phenylhexahydroprymidine-4,6-dione from pharmaceutical wastewater

Research Paper | September 1, 2021

| Download 9

Odinma, Stanley Chukwudindu

Key Words:

J. Bio. Env. Sci.19( 3), 7-16, September 2021


JBES 2021 [Generate Certificate]


Pollution of water bodies with pharmaceutical organic recalcitrant has been a threat to living thing and its environment due to unknown impart and possible damages. This, however necessitate the present study which was focused primarily on the development of model, optimization and kinetic reactivity on the application of Photo-Fenton process on degradation of a barbiturate (5-ethyl-5-phenylhexahydroprymidine-4,6-dione) in aqueous solution. The principle of this method is based on the in-situ generation of hydroxyl radicals from H2O2 and reconversion of Fe3+ to Fe2+.Influences of major operating parameters on the removal efficiency were investigated using Central Composite Design (CCD) of Response Surface Methodology (RSM). 22µl H2O2 and 8.8mg Fe2+ at pH 3 was found to be the optimum with 97.02% removal within 30minutes reaction time. From the kinetic study, it was observed that as the initial dose decreases to 100mg/L, 99.77% removal was achieved and at 50 & 75mg/L, 100% achieved within 10minutes. Both statistical and experimental validations of the Model were verified and found to be in good agreement. Pseudo-first order kinetics reaction rate and half-life were obtained at 0.096min-1 and 7.22mins respectively at a regression (R2) of 0.913. Electrical energy per order (EE/O) and cost (Naira) of electrical energy at optimum conditions for this experiment was found to be 1.96kWh/m3 and 50.41₦/m3 respectively.


Copyright © 2021
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Development of model and subsequent kinetic study on photo-fenton degradation of 5-ethyl-5-phenylhexahydroprymidine-4,6-dione from pharmaceutical wastewater

Aminot Y, Fuster L, Pardon P, Le K, Budzinski H. 2018. Suspended solid moderate the degradation and sorption of waste water derived pharmaceuticals in esuarine waters. Sci. Total Environ 612, 39-48.

Asaithambi P, Esayas A, Baharak S, Abdul R, Abdul A. 2015. Electrical energy per order determination for the removal pollutant from industrial wastewater using UV/Fe2+/H2O2 process: Optimization by response surface methodology. Water Resource and Industry 18, 17-32.

Bourgin M, Beck B, Borowska E, Fleiner J, Salhi E, Teichler R, von GU, Siegrist H, McArdell CS. 2018. Evaluation of a full-scale wastewater treatment plant upgraded with ozonation and biological post treatments: Abatement of micropollutants, formation of transformation products and oxidation by-products. Water Res 129, 486-498.

Brodie MJ, Dichter MA. 1996. Anti­epileptic drugs. N. Engl. J. Med 334, 168-175.

De la CN, Esquius L, Grandjean D, Magnet A, Tungler A, de Alencastro LF, Pulgarı´n C. 2013. Degradation of emergent contaminants by UV, UV/H2O2 and neutral photo- Fenton at pilot scale in a domestic wastewater treatment plant. Water Res 47, 5836.

Dong MM, Trencolm R, Rosario-Ortiz FL. 2015. Photochemical degradation of atenolol, carbamazepine, meprobamate, phenytoin and primidone in wastewater effluents. J. Hazard. Mater 282, 216-223.

FDA. 2013. Primidone. Silver Spring (MD): United States Food and Drug Administration.Available from: http://www.accessdata.fda.gov/scripts/cder/drugsatfda /index.cfm?fuseaction=Search.Drug Details, retrieved 28 April 2020.

Halling-Sorensen B, Nielsen SN, Lanzky PF, Ingerslev F, Lutzhoft HCH, Jorgensen SE. 1998. Occurrence, fate and effects of pharmaceutical substances in the environment- A Review, Chemosphere 36, 357-394.

Hass U, Duennbier U, Massmann G. 2012. Occurrence and distribution of psychoactive compounds and their metabolites in the urban water cycle of Berlin (Germany). Water Res 46, 6013.

Henzler AF, Greskowiak J, Massmann G. 2014. Modeling the fate of organic micropollutants during river bank filtration (Berlin, Germany). J. Cont. Hydrol 156, 78.

Hummel D, Loeffler D, Fink G, Ternes TA. 2006. Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry. Environ. Sci. Technol 40, 7321-7328.

Livingston JV. 2005. Agriculture and Soil Pollution: New Research. New York: Nova Science Publishers.

Manuel AF, Eva MR, Manuel C, Fernando JB. 2019. Ozone-Based Advanced Oxidation Process for Primidone removal in water using simulated sola radiation and TiO2 or WO3 as Photocatalyst. Molecules 24(1728), 1-18.

Massmann G, Heberer T, Gruetzmacher G, Duennbier U, Knappe A, Meyer H, Mechlinski A, Pekdeger A. 2007. Drinking-water production in urban environments bank filtration in Berlin. Grundwasser 12, 232-245.

NTP. 2000. NTP Toxicology and Carcinogenesis Studies of Primidone (CAS No. 125–33–7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser 476, 1-290. PMID: 12571687

Odinma SC, Ekejiuba IOC, Okafor EC, Chukwujindu CN. 2021. Empirical modeling and Validation of Classical Fenton Technology for complete removal of anticonvulsant from high dosed simulate wastewater. IOSR-JAC 14(2), 25-35.

Oehha. 2013. Chemicals known to the state to cause cancer or reproductive toxicity. CA: Office of Environmental Health Hazard Assessment, State of California Environmental Protection Agency. Available from: http://oehha.ca.gov/prop65/prop65 _list/files/P65single052413.pdf.

Perucca P, Gilliam FG. 2012. Adverse effects of antiepileptic drugs. Lancet Neurol 11, 792-802

Real FJ, Benitez FJ, Acero JL, Sagasti JJP, Casas F. 2009. Kinetics of the chemical oxidation of the pharmaceuticals primidone, ketoprofen, and diatrizoate in ultrapure and natural waters. Ind. Eng. Chem. Res. 48, 3380.

Reh R, Licha T, Geyer T, No¨dler K, Sauter M. 2013. Occurrence and spatial distribution of organic micro-pollutants in a complex hydrogeological karst system during low flow and high flow periods, results of a two-year study. Sci. Total Environ 443, 438.

Sasa S, Ning L, Ming Z, Gang X, Lian T, Jinzhong Y, Minghong W. 2015. Degradation of anticonvulsant Drug primidone in aqueous solution by UV photooxidation processes. Environmental Engineering Science 32(5), 436-444.

Thomas O. 2003. Photochemical purification of water and air. WISEY-VCH Verlag pp. 46-52.