Does systemic inflammation and allergen-specific IgE are related to each other in presence asthma

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Research Paper 01/10/2011
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Does systemic inflammation and allergen-specific IgE are related to each other in presence asthma

Mojtaba Izadi, Somayeh Bakhshi, Payman Abrifam, Davood Khorshidi
Int. J. Biosci.1( 5), 89-94, October 2011.
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High sensitivity C-reactive protein (hs-CRP) is an inflammatory cytokine known to be related to inflammation diseases and elevated immunoglobulin E (IgE) is considered as an objective marker of allergy and has been associated with a number of respiratory disorders. Recently, it has been hypothesized that there is a strong significant between systemic and allergic responses in adult asthma patients. To test the hypothesis, we compared fasting serum IgE and hs-CRP in middle-aged men with asthma and those with healthy subjects. In addition, the relationship between IgE and hs-CRP were observed in asthma patients. Serum IgE and hs-CRP in asthma patients was significant higher than healthy subjects. There is a significant positive correlation between serum CRP and IgE in asthma patients (p = 0.023). These date support of asthma as an inflammation disease. Additionally, our study to support previous study demonstrated that inflammation mechanism play important role in pathogenesis of impaired airway in respiratory diseases.


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