Eclipta alba (Family: Asteraceae): A review of botanical, ethnopharmacological, phytochemical and pharmacological studies

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Review Paper 01/12/2020
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Eclipta alba (Family: Asteraceae): A review of botanical, ethnopharmacological, phytochemical and pharmacological studies

Ayisha Shaukat, Khalid Hussain, Nadeem Irfan Bukhari, Naureen Shehzadi, Abida Qamar, Sidra Siddique, Sidra Saeed, Hina Shahbaz
Int. J. Biosci.17( 6), 338-352, December 2020.
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Abstract

A traditional medicinal plant which is native to tropical, subtropical and warm temperate areas of the globe. The plant is distributed as a contaminant in rice seed in France and Philippines. Running water especially floods distributes the seeds from field to field. The plant is common for its medicinal value in alternative systems of holistic health (Ayurvedic, Unani, Homeopathy, Sidha and Chinese) and herbal medicines. Scientific evidence for the folklore claim of the plant has been investigated in many studies but a summary of the data is not available. Detailed literature review of the plant with the recent advancement in research along with therapeutic potentials and scientific evidence are given herein. Databases such as Google Scholar, Elsevier, Science Direct and PubMed have been used to access the literature, thus excluding articles related to ecology, agriculture and synthetic work. The review indicated new potentials for the plant and revealed pharmacological activities supporting the traditional claim. For example, antitumor activity studies of the plant revealed its use for treating tumors. Moreover, clinical studies of the plant extract are mandatory based on safety, efficacy and pharmacokinetic data. The current review may be helpful for researchers intending to extend the research on the plant as well as in the preparation of evidence-based formulations in the pharmaceutical industry.

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Abdel-Kader MS,Bahler BD, Malone S, Werkhoven MC,Van Troof F, David, Mamber SW. 1998. DNA-Damaging Steroidal Alkaloids from Eclipta alba from the Suriname Rainforest. Journal of Natural Product 61, 1202-1208. https://doi.org/10.1021/np970561c

Ananthi J, Prakasam A, Pugalendi KV. 2003. Antihyperglycemic activity of Eclipta alba leaf on alloxan induced diabetic rats. Yale Journal of Biology and Medicine 76, 97-102.

Arun K, Balasubramanian U. 2011. Comparative study on Hepatoprotective activity of Aegle marmelos and Eclipta alba against alcohol induced in albino rats. International Journal of Environmental Sciences 2, 389-402.

Arunachalam G, Subramanian N, Pazhani GP, Ravich V. 2009. Anti-inflammatory activity of methanolic extract of Eclipta prostrata L (Astearaceae). African journal of pharmacy and pharmacology 3, 097-100.

Banji O, Banji D, Annamalai AR, Manavalan R. 2007. Investigation on the effect of Eclipta alba on animal models of learning and memory. Indian Journal of Physiology and Pharmacology 51, 274.

Begum S, Lee MR, Gu LJ, Hossain J, Sung CK. 2015. Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice. International Journal Molecular Medicine 35, 496-502. https://doi.org/10.3892/ijmm.2014.2022

Bhargava KK, Krishnaswamy NR, Seshadri TR. 1970. Isolation of desmethylwedelolactone & its glucoside from Eclipta alba. Indian Journal of Chemistry 8, 664-665. https://doi.org/10.1002/chin.197048418

Borkataky MUNMI, Kakoty BB, Saikia LR. 2013. Proximate analysis and antimicrobial activity of Eclipta alba (L.) Hassk. a traditionally used herb. International Journal of Pharmacy and Pharmaceutical Sciences 5, 149-154.

Chaudhary H, Dhuna V, Singh J, Kamboj SS, Seshadri S. 2011. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: an in vitro study. Journal of Ethnopharmacology 136, 363-367. https://doi.org/10.1016/j.jep.2011.04.066

Cherdtrakulkiat R, Boonpangrak S, Ruchirawat S, Pingaew R, Prachayasittikul V, Prachayasittikul S. 2015. Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn. Journal of Applied Pharmaceutical Science 5, 46-50. https://doi.org/10.7324/japs.2015.50308

Dalal S, Kataria SK. 2010. Phytochemical screening of ethanolic extract and antibacterial activity of Eclipta prostrata. Asian Journal of Chemistry 22, 7336.

Das B, Chakravarty AK. 1992. Ecliptal (I) a New Terthienyl Aldehyde from Eclipta alba. ChemInform 23, 1052-1053. https://doi.org/10.1002/chin.199205282

Das K, Duarah P. 2014. Traditional knowledge of the women’s of Kaibarta community of Assam about the application of phytoremedies in certain common childhood diseases. International Research Journal of Biological Sciences 3, 57-63.

Dave R. 2009. In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview. African Journal of Microbiology Research 3, 981-996.

Desireddy RB, Sowjanya GN, Reddy KLL, Sowjanya T. 2012. Screening of Eclipta alba extracts for anticancer activity. International Journal of Research and Development in Pharmacy & Life Sciences 1, 203-205.

Devi K, Karthikai GD, Thirumaran G, Arumugam R, Anantharaman P. 2010. Antibacterial activity of selected medicinal plants from Parangipettai coastal regions; Southeast coast of India. Academic Journal of Plant Sciences 3, 122-125.

Diogo LC, Fernandes RS, Marcussi S, Menaldo DL, Roberto PG, Matrangulo PV, Lourenço MV. 2009. Inhibition of snake venoms and phospholipases A2 by extracts from native and genetically modified Eclipta alba: isolation of active coumestans. Basic and clinical pharmacology and toxicology 104, 293-299. https://doi.org/10.1111/j.1742-7843.2008.00350.x

Dungca NTP. 2016. Protective effect of the methanolic leaf extract of Eclipta alba (L.) Hassk. (Asteraceae) against gentamicin-induced nephrotoxicity in Sprague Dawley rats. Journal of Ethnopharmacology 184, 18-21. https://doi.org/10.1016/j.jep.2016.03.002

Gautam A, Batra A. 2012. Ethnomedicinal plant product used by the local traditional practitioners in Mount Abu. World Journal of Pharmaceutical Sciences 1, 10-18.

Girish HV, Satish S. 2008. Antibacterial activity of important medicinal plants on human pathogenic bacteria-a comparative analysis. World Applied Sciences Journal 5, 267-271.

Govindarajan M, Karuppannan P. 2011. Mosquito larvicidal and ovicidal properties of Eclipta alba (L.) Hassk (Asteraceae) against chikungunya vector, Aedes aegypti (Linn.)(Diptera: Culicidae). Asian Pacific Journal of Tropical Medicine 4, 24-28. https://doi.org/10.1016/s1995-7645(11)60026-6

Hussain K, Nisar MF, Majeed A, Nawaz K, Bhatti KH. 2010. Ethnomedicinal survey for important plants of Jalalpur Jattan, district Gujrat, Punjab, Pakistan. Ethnobotanical Leaflets 7, 11.

Indhuleka A, Jeyaraj M. 2019. Hepatoprotective Effect of Eclipta alba on Membrane Marker Enzymes against Paracetamol Induced Liver Damage.  Oriental Journal of Chemistry 35, 1215-1219. https://doi.org/10.13005/ojc/350343

Jena MONALISA, Jena J, Biswal SB, Mishra SWATI, Pal ABHISEK. 2013. Effect of Eclipta alba on fructose induced hypertension in albino rats. International Journal of Pharmacy and Pharmaceutical Sciences 5, 281-285.

Kannabiran K. 2008. Antimicrobial activity of saponin fractions of the leaves of Gymnema sylvestre and Eclipta prostrata. World Journal of microbiology and Biotechnology 24, 2737-2740. https://doi.org/10.1007/s11274-008-9758-7

Karthikumar S, Vigneswari K, Jegatheesan K. 2007. Screening of antibacterial and antioxidant activities of leaves of Eclipta prostrata (L). Scientific Research and Essays 2, 101-104.

Kim DI, Lee SH, Choi JH, Lillehoj HS, Yu MH, Lee GS. 2008. The butanol fraction of Eclipta prostrata (Linn) effectively reduces serum lipid levels and improves antioxidant activities in CD rats. Nutrition research 28, 550-554. https://doi.org/10.1016/j.nutres.2008.05.003

Kobori M, Yang Z, Gong D, Heissmeyer V, Zhu H, Jung YK, Yuan C. 2004. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death & Differentiation 11, 123-130. https://doi.org/10.1038/sj.cdd.4401325

Koyama H, Boufford DE. 1981. Proposal to change one of the examples in Article 57. Taxon 30, 504-505. https://doi.org/10.2307/1220166

Kumar D, Gaonkar RH, Ghosh R, Pal BC. 2012. Bio-assay guided isolation of α-glucosidase inhibitory constituents from Eclipta alba. Natural product communications 7, 989-990. https://doi.org/10.1177/1934578×1200700807

Kumar GS, Jayaveera KN, Kumar CK, Sanjay UP, Swamy BM, Kumar DV. 2007. Antimicrobial effects of Indian medicinal plants against acne-inducing bacteria. Tropical Journal of Pharmaceutical Research 6, 717-723. https://doi.org/10.4314/tjpr.v6i2.14651

Kumar S, Dhanani T. 2013. Development and validation of a rapid high performance liquid chromatography-photodiode array detection method for estimation of a bioactive compound wedelolactone in extracts of Eclipta alba. Brazilian Journal of Pharmaceutical Sciences 49, 57-63. https://doi.org/10.1590/s198482502013000100007 

Kumari CS, Govindasamy S, Sukumar E. 2006. Lipid lowering activity of Eclipta prostrata in experimental hyperlipidemia. Journal of Ethnopharmacology 105, 332-335. https://doi.org/10.1016/j.jep.2005.10.031

Lans C. 2007. Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine. Journal of Ethnobiology and Ethnomedicine 3, 1-12. https://doi.org/10.1186/1746-4269-3-3

Lee HK, Moody K. 1988. Germination and Emergence of Eclipta prostrata (L.) L. Korean Journal of Weed Science 8, 299-307.

Lee MK, Ha NR, Yang H, Sung SH, Kim GH, Kim YC. 2008. Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells. Phytomedicine 15, 775-780. https://doi.org/10.1016/j.phymed.2007.10.004

Lee MK, Ha NR, Yang H, Sung SH, Kim YC. 2009. Stimulatory constituents of Eclipta prostrata on mouse osteoblast differentiation. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 23, 129-131. https://doi.org/10.1002/ptr.2560

Lenza VA, Morel LJ, Coppede JS, Fernandes VC, Martinez-Rossi NM, Franca SC, Fachin A. 2009. Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk.(Asteraceae). Latin American Journal of Pharmacy 28, 863-868.

Liu QM, Zhao HY, Zhong XK, Jiang JG. 2012. Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity. Food and Chemical Toxicology 50, 4016-4022. https://doi.org/10.1016/j.fct.2012.08.007

Maddi R, Devilal K, Babu S, Harika P. 2017. In-vitro MABA anti-tuberculosis assay of Eclipta alba (L.) Hassk whole plant. The Pharma Innovation Journal 6, 103.

Malan DF, Neuba DF. 2011. Traditional practices and medicinal plants use during pregnancy by Anyi-Ndenye women (Eastern Côte d’Ivoire). African Journal of Reproductive Health 15, 85-94. https://doi.org/10.1186/s13002-015-0004-8

Ma-Ma K, Nyunt N, Tin KM. 1978. The protective effect of Eclipta alba on carbon tetrachloride-induced acute liver damage. Toxicology and Applied Pharmacology 45, 723-728. https://doi.org/10.1016/0041-008x(78)90165-5

Manvar D, Mishra M, Kumar S, Pandey VN. 2012. Identification and evaluation of anti-hepatitis C virus phytochemicals from Eclipta alba. Journal of Ethnopharmacology 144, 545-554. https://doi.org/10.1016/j.jep.2012.09.036

Mors WB, Do Nascimento MC, Parente J, Da Silva MH, Melo PA, Suarez-Kurtz G. 1989. Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae). Toxicon 27, 1003-1009. https://doi.org/10.1016/0041-0101(89)90151-7

Mugale MN, Balachandran C. 2020. Haematological protective effect of raw extract and nano-Eclipta alba–treated rats in experimentally induced hepatocarcinogenesis. Comparative Clinical Pathology 29, 547-552. https://doi.org/10.1007/s00580-020-03092-1

Naik S, Gurushanthaiah M, Kavimani M, Mahesh GM. 2019. Extraction of phytochemical constituents from the root of Eclipta alba through gas chromatography-mass spectrometry procedure.  International Journal of Research in Pharmaceutical Science 10, 1238-1242. https://doi.org/10.26452/ijrps.v10i2.414

Naik S, Gurushanthaiah M, Lokanadham S. 2019. Protective role of Eclipta alba against hyperlipidemia induced by high-fat diet in albino ratsInternational Journal of Pharmaceutical Research 10, 1181-1184. https://doi.org/10.26452/ijrps.v10i2.403

Neeraja PV, Margaret E. 2012. Eclipta alba (L.) Hassk: a valuable medicinal herb. International Journal of Current Pharmaceutical Review and Research 2, 188-197.

Pal SN, Narasimhan N. 1943. A note on the alkaloid in Eclipta alba Hassk. Journal of the Indian Chemical Society 20, 1.

Panthi MP, Singh AG. 2013. Ethnobotany of Arghakhanchi District, Nepal: plants used in dermatological and cosmetic disorders. International Journal of Applied Sciences and Biotechnology 1, 27-32. https://doi.org/10.3126/ijasbt.v1i2.8199

Patel MB, Panchal SJ, Patel JA. 2009. Antianaphylactic activity of alcoholic extract of Eclipta alba. Journal of young pharmacists 1, 244. https://doi.org/10.4103/0975-1483.57072

Patel Rakesh K, Pundarikakshudu K, Bhandari A. 2012. Evaluation of anti-inflammatory activities of extract of leaves of Eclipta alba and Wedelia calendulacea. Pharma Science Monitor 3, 1846-1852.

Peraman MK, Ramalingam P, Bapatla JNNS. 2011. Antiinflammatory and antimicrobial activities of the extracts of Eclipta alba leaves. European Journal of Experimental Biology 1, 172-177.

Pithayanukul P, Laovachirasuwan S, Bavovada R, Pakmanee N, Suttisri R. 2004. Anti-venom potential of butanolic extract of Eclipta prostrata against Malayan pit viper venom. Journal of Ethnopharmacology 90, 347-352. https://doi.org/10.1016/j.jep.2003.10.014

Prabu K, Shankarlal S, Natarajan E, Mohamed Sadiq A. 2011. Antimicrobial and antioxidant activity of methanolic extract of Eclipta alba. Advances in Biological Research 5, 237-240.

Prajapati H, Patel MB. 2012. Potent α-glucosidase inhibitor and anti-glycemic agent from Eclipta alba. Chemistry & Biology Interface 2, 38-47.

Premasudha P, Venkataramana M, Abirami M, Vanathi P, Krishna K, Rajendran R. 2015. Biological synthesis and characterization of silver nanoparticles using Eclipta alba leaf extract and evaluation of its cytotoxic and antimicrobial potential. Bulletin of Materials Science 38, 965-973. https://doi.org/10.1007/s12034-015-0945-5

Rahman MA, Uddin MN, Ahmed NU, Islam MR. 2012. Phytochemical analysis and effect of whole Eclipta alba ethanolic extract on the central nociception and inflammation in rodent models. Journal of pharmaceutical and biomedical sciences 25, 130-140.

Rahman MS, Rashid MA. 2008. Antimicrobial activity and cytotoxicity of Eclipta prostrata. Oriental Pharmacy and Experimental Medicine 8, 47-52. https://doi.org/10.3742/opem.2008.8.1.047

Rahmatullah M, Mollik AH, Paul AK, Jahan R,  Khatun A, Seraj S, Taufiq-ur-Rahman M. 2010. A comparative analysis of medicinal plants used to treat gastrointestinal disorders in two sub-districts of Greater Khulna Division, Bangladesh. Advances in Natural and Applied Sciences 4, 22-29.

Rajakumar G, Rahuman AA. 2011. Larvicidal activity of synthesized silver nanoparticles using Eclipta prostrata leaf extract against filariasis and malaria vectors. Acta tropica 118, 196-203. https://doi.org/10.1016/j.actatropica.2011.03.003

Rangineni V, Sharada D, Saxena S. 2007. Diuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects: a pilot study. Journal of Medicinal Food 10, 143-148. https://doi.org/10.1089/jmf.2006.0000

Raveesha KA, Shrisha DL. 2013. Antidermatophytic activity of Eclipta prostrata L. against human infective Trichophyton and Microsporum spp. International Journal of Chemical and Analytical Science 4, 136-138. https://doi.org/10.1016/j.ijcas.2013.05.003

Reddy SN, Farhana A, Anjum A, Bakshi V. 2017. In vivo Anthelmenthic Activity of Various Extracts of Eclipta alba Leaves. International Journal of Applied Pharmaceutical Sciences and Research 2, 32-35. https://doi.org/10.21477/ijapsr.v2i2.7835

Roy RK, Thakur M, Dixit VK. 2008. Hair growth promoting activity of Eclipta alba in male albino rats. Archives of dermatological research 300, 357-364. https://doi.org/10.1007/s00403-008-0860-3

Sagar BPS, Panwar R, Goswami A, Kadian K, Tyagi K, Chugh M, Zafar R. 2006. Pharmacokinetic interactions of antihepatotoxic wedelolactone with paracetamol in wistar albino rats. Pharmaceutical biology 44, 554-561. https://doi.org/10.1080/13880200600885242

Sahu CR, Nayak RK, Dhal NK. 2013. Traditional herbal remedies for various diseases used by tribals of Boudh district, Odisha, India for sustainable development. International Journal of Herbal Medicine 1, 12-20.

Santhosh S, Velmurugan S, Annadurai R. 2015. Phytochemical screening and antimicrobial activity of medicinal plants (Eclipta prostrata L. and Sphaeranthus indicus L.). International Journal of Pure and Applied Biosciences 3, 271-279.

Saraswat VP, Verma S, Musale SV, Jaiswal ML. 2015. A review on traditional and folklore uses, phyto-chemistry and pharmacology of Eclipta alba (L) Hassk. International Ayurvedic Medical Journal 3, 2462-2469.

Sazia SS, Shankar P, Nath R, Sachan AK, Dixit RK. 2015. Effect of metformin Vs. Eclipta alba on blood glucose level in diabetic patients. International Journal of Pharmacognosy and Phytochemical Research 7, 215-218.

Seshadri S, Nair P, Purandhar K, Prajapati B, Rajput P, Jena PK. 2014. Determining the reversible potentials of hydro alcoholic extracts of Eclipta alba in boric acid induced male accessory reproductive organ toxicity. The Journal of Toxicology and Health 104, 381-394.

Sharma S, Sikarwar M. 2008. Wound healing activity of ethanolic extract of leaves of Eclipta alba. Pharmacognosy Magazine 4, 108-111.

Sharma A, Sharma M, Mishra A, Sharma S, Kumar B, Bhandari A. 2011. A review on thar plants used in liver diseases. International Journal of Research in Pharmacy and Chemistry 1, 224-236.

Shen P, Yang X, Jiang J, Wang X, Liang T, He L. 2017. Wedelolactone from Eclipta alba inhibits lipopolysaccharide-enhanced cell proliferation of human renal mesangial cells via NF-κB signaling pathway. American Journal of Translational Research 9, 21-32.

Singh B, Saxena AK, Chandan BK, Agarwal SG, Anand KK. 2001. In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian Journal of Physiology and Pharmacology 45, 435-441.

Singh DV, Sutar N, Sutar R, Singh P, Kumar R. 2013. Phytochemical investigation and diuretic activity of Eclipta prostrata leaves. International Journal of Bioassays 2, 300-303.

Singh PAHUP. 1988. Naturally-occurring thiophene derivatives from Eclipta species. Bioactive molecules 7, 179-186.

Singh VK, George CX, Gupta KP, Gupta BM. 1983. Antiviral activity of plant extract Liv. 52 in mice experimentally infected with semliki forest encephalitis virus. Science and Culture 49, 354-356.

Sollepura Boregowda R, Murali NC, Udayashankar AR, Niranjana SS, Lund OS. Prakash H. 2019. Antifungal Activity of Eclipta alba Metabolites against Sorghum Pathogens. Plants 8, 1-6.

Sudhakar P, Shashikanth J. 2012. Ethnomedicinal importance of some ethnomedicinal importance of some weeds grown in sugarcane crop fields of Nizamabad district, Andhrapradesh, India. Life sciences leaflets 32, 51.

Tewtrakul S, Subhadhirasakul S, Cheenpracha S, Karalai C. 2007. HIV‐1 protease and HIV‐1 integrase inhibitory substances from Eclipta prostrata. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 21, 1092-1095. https://doi.org/10.1002/ptr.2252

Thapliyay S, Mahadevan N, Nanjan M. 2011. Analysis of wedelolactone in Eclipta alba and its formulation by HPTLC. J. of Global Trends in Pharmaceutical Sciences 2, 450-457.

Thirumalai T, David E, Therasa SV, Elumalai EK. 2011. Restorative effect of Eclipta alba in CCl4 induced hepatotoxicity in male albino rats. Asian Pacific Journal of Tropical Disease 1, 304-307. https://doi.org/10.1016/s2222-1808(11)60072-8

Thomas P, Gururaja MP, Joshi H, Prasannashama K, D’Souza U, Chacko N, Rajesh KS. 2019. Ameliorative Potential of Eclipta alba on Gentamycin Induced Renal Toxicity in Rats. Research Journal of Pharmacy and Technology 12, 192-196. https://doi.org/10.5958/0974-360x.2019.00035.0

Umemoto S, Kobayashi H, Ueki K, Ito M. 1998. Correct names of Japanese Eclipta. Journal of Weed Science and Technology 43, 244-248.

Upadhyay RK, Pandey MB, Jha RN, Pandey VB. 2001. Eclalbatin, a triterpene saponin from Eclipta alba. Journal of Asian natural products research 3, 213-217. https://doi.org/10.1080/10286020108041393

Vaidyanathan D, Senthilkumar MS, Basha MG. 2013. Studies on ethnomedicinal plants used by malayali tribals in Kolli hills of Eastern ghats, Tamilnadu, India. Asian Journal of Plant Science and Research 3, 29-45.

Vashistha BD, Kaur M. 2013. Floristic and ethno botanical survey of Ambala District, Haryana. International Journal of Pharma and Bio Sciences 4, 353-360.

Verma RC, Shankar P, Dwivedi S, Dixit RK. 2012. Effects of Eclipta alba and Boerhaavia diffussa on Normal Blood Pressure and Hypertension in Rats and their Comparison with Amlodipine. International Journal of Pharmaceutical Sciences and Research 3, 1832.

Wang A, Geng R, Yi LI, Wei X, Chen Y, Zhang, S, Zhang T. 2015.  Effect of Eclipta alba on learning and memory ability and brain derived neurotrophic factor with Alzheimer’s rats. Chinese Journal of Behavioural Medicine and Brain Science 24, 212-214.

Yadav NK, Arya RK, Dev K, Sharma C, Hossain Z, Meena S, Singh RK. 2017. Alcoholic extract of Eclipta alba shows in vitro antioxidant and anticancer activity without exhibiting toxicological effects. Oxidative Medicine and Cellular Longevity 2017, 1-18. https://doi.org/10.1155/2017/9094641

Yahara S, Ding N, Nohara T. 1994. Oleanane glycosides from Eclipta alba. Chemical and pharmaceutical bulletin 42, 1336-1338. https://doi.org/10.1248/cpb.42.1336

YRKV TR, Satishchandra A. 2020. Anti-arthritic evaluation of Eclipta alba in a murine model Freund’s adjuvant provoked arthritis. International Journal of Research in Pharmaceutical Sciences 11, 1012-1017. https://doi.org/10.26452/ijrps.v11i1.1929

Zhang JS, Guo QM. 2001. Studies on the chemical constituents of Eclipta prostrata (L). Yao xue xue bao= Acta pharmaceutica Sinica 36, 34-37.

Zhang M, Chen YY, Di XH, Liu M. 1997. Isolation and identification of ecliptasaponin D from Eclipta alba (L.) Hassk. Yao xue xue bao= Acta pharmaceutica Sinica 32, 633-634.