Effect gingivitis on anti-mullierian hormone in females with polycystic ovary syndrome

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Research Paper 01/09/2018
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Effect gingivitis on anti-mullierian hormone in females with polycystic ovary syndrome

Shaimaa Sabte Mutlak, Noora Abd Awad, Elham Hazeim Abdulkareem
Int. J. Biosci.13( 3), 165-172, September 2018.
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Polycystic ovary syndrome is a mutual disease affected about 4% to 12% women in propagative age. Anti-mullerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor-b family. It plays a master role in cell growth and differentiation. Polycystic ovary syndrome (PCOS) is a hormonal disorder of women that not only is the leading cause of infertility but also shows a reciprocal link with oral health. Gingivitis was inflammed disorders it has linked with altered vascular reaction, high levels of adhesion molecules and elevated expression of local and systemic inflammatory cytokines and adipokines like tumor necrosis factor- alpha and transforming growth factor-beta. Increased gingival inflammation is related with increased synthesis of steroid hormone. Therefore, The aims of the study to examine the effect gingivitis and PCOS on levels of AMH and study the relation between PCOS and gingivitis in women and if AMH is useful marker in diagnosis of gingivitis and PCOS. A total 84 women of age group between (20 – 28) years were included in this study. Twenty one female who had PCOS and (21) female with periodontal diseases (gingivitis), (21) female who possess both PCOS and gingivitis and (22) healthy females with regular menstrual cycle who presented sequentially and prospectively to the Department of Endocrinology of Al-Rumadi teaching hospital/ Al-Anbar/Iraq. High significant elevation in saliva AMH in PCOS with gingivitis group than in PCOS, gingivitis and control group p<0.05. High concentration of AMH in PCOS with gingivitis make suggested all Physicians must refer PCOS patients to oral health clinic providers for a comprehensive oral evaluation and treatment.


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