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Effect of a stepwise cycling on insulin resistance and CRP in adult males with type II diabetic

Research Paper | September 1, 2012

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Sedghi Hussein, Pourtoeiserkani Mohammad, Dooaly Hussein, Daraei Shokrabad Firooz

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J. Bio. Env. Sci.2( 9), 74-79, September 2012


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Recent studies have shown that type II diabetic is associated with systemic inflammation. This study was aimed to determine the effect of a single stepwise cycling on serum C-reactive protein and insulin resistance in type II diabetic patients. For this purpose, seventeen adult males with type II diabetic were selected to participation in this study by accessible sampling. Blood samples were collected before and immediately after a stepwise cycling test in order to measuring serum CRP, glucose concentration and insulin resistance. Student’s t-tests for paired samples were performed to determine significance of changes in variables by exercise test. No significant change was found in serum CRP by cycling test in subjects (1161 ± 214 vs 1184 ± 287 ng/ml, p=0.234). Cycling test resulted in significant decrease in glucose concentration (234±34 vs 212 ± 33 mg/dl, p=0.039), but insulin resistance was not changed (4.67 ± 1.23 vs 4.65 ± 1.12, p=0.148). Based on these data, we conclude that single cycling test for short-time can not improve serum CRP and insulin resistance while is associated with glucose reduction.


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Effect of a stepwise cycling on insulin resistance and CRP in adult males with type II diabetic

Albert CM, Ma J, Rifai N, Stampfer MJ, Ridker PM. 2002. Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 105(22), 2595-9.

Bautmans I, Njemini R, Vasseur S. 2005. Biochemical changes in response to intensive resistance exercise training in the elderly. Gerontology 51, 253–265.

de Salles BF, Simão R, Fleck SJ, Dias I, Kraemer-Aguiar LG, Bouskela E. 2010. Effects of resistance training on cytokines. Int J Sports Medn 31(7), 441-50.

DeFronzo RA. Lilly lecture 1987: the triumvirate: beta-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37: 667-687.

Eizadi M, Kohandel M, Kasbparast JRM, Sars hin A. 2011. Acute exercise improves serum adiponectin not leptin in sedentary adult obese men. South Asian J Exp Biol 1(6), 298-304.

Fallon KE, Fallon SK & Boston T. 2001. The acute phase response and exercise: court and field sports. Br J Sports Med 35, 170–173.

Fischer CP, Plomgaard P, Hansen AK. 2004. Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Endocrinol Metabol 287, 1189–1194.

Hammett CJK, Prapavessis H, Baldi JC. 2006. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. Am Heart J 151, 367.

Hong J, Gu W, Zhang Y, Yang Y, Shen C, Xu M, Li X, Wang W, Ning G. 2007. The interplay of insulin resistance and beta-cell dysfunction involves the development of type 2 diabetes in Chinese obeses. Endocrine 31, 93–99.

Julia W, Karen C, Javier R, Ascension M. 2010. Role of physical activity on immune function Physical activity, exercise and low-grade systemic inflammation. Proceedings of the Nutrition Society. 69, 400–406.

Kohut ML, McCann DA, Russell DW. 2006. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 20, 201– 209.

Lakka TA, Lakka HM, Rankinen T. 2005. Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE family study. Eur Heart J 26, 2018–2025.

Marcell  TJ,  McAuley  KA,  Traustadottir  T. 2005. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 54, 533–541.

Mattusch F, Dufaux B, Heine O. 2001. Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med 21, 21–24.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Pearson TA, Mensah GA, Alexander RW. 2003. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107, 499–511.

Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286(3), 327-34.

Reaven GM. 1988. Banting lecture 1988: role of insulin resistance in human disease. Diabetes. 37: 1595- 1607.

Ridker PM. 2003. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107(3), 363-9.

Stewart LK, Flynn MG, Campbell WW. 2005. Influence of exercise training and age on CD14 + cell-surface expression of toll-like receptor 2 and 4. Brain Behav Immun 19, 389–397.

Stumvoll M, Goldstein BJ, Van Haeften TW. 2005. Type 2 diabetes: principles of pathogenesis and therapy,” The Lancet 365(9467), 1333–1346.

Utzschneider K, Prigeon R, Carr D, Hull R, Tong J, Shofer J, Retzlaff B, Knopp R, Kahn S. 2006. Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between  insulin  sensitivity and  insulin  responses. Diabetes Care 29, 356–362.

Wang C, Guan Y, Yang J. 2010. Cytokines in theProgression of Pancreatic β-Cell Dysfunction. Int J Endocrinol. 2010; 2010:515136. Epub 2010 Nov 14.