Effect of aerobic training on insulin resistance and plasma adiponectin in type 2 diabetes women

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Research Paper 01/07/2013
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Effect of aerobic training on insulin resistance and plasma adiponectin in type 2 diabetes women

Behbudi Laleh, Hajirasouli Masoud, Afsharmand Zohreh
J. Bio. Env. Sci.3( 7), 42-53, July 2013.
Certificate: JBES 2013 [Generate Certificate]

Abstract

Over the past two decades, the global prevalence of diabetes has substantially increased. Aerobic exercise has identified as a specific treatment and major strategy for treatment of patients suffering type-2 diabetes. So this study aims to explore the effect of aerobic exercise on concentration of plasma adiponectin and insulin resistance in women with type-2 diabetes. 20 diabetic women were placed as subjects into aerobic exercise and control groups. The aerobic exercise program included three weekly walking sessions for 30 to 60 minutes with the intensity of 60 to 70 HRR. Plasma adiponectin concentration, fasting glucose, insulin, blood lipids and body measurements were measured at the beginning of the program (pre- test), fourth week (during the test) and at end of the sixth week (post-test). Independent t test was used to analyze the data and the two-way analysis of variance was made using repeated measurements. After 8 weeks of exercise, plasma adiponectin concentration and insulin resistance did not represent any significant change (P>0.05), but fasting glucose represented a significant decrease (P<0.05). The findings of this study showed that 8 weeks of aerobic exercise would not have a significant influence on plasma adiponectin and insulin resistance in type 2 diabetic women; however, it had a significant effect on weight, BMI and fasting glucose level of this group of diabetic women. In addition, 8 weeks of aerobic exercise brought about a significant impact on VO2max. Therefore on the basis results from this study it is recommended that type-2 diabetes able to perform aerobic exercises should benefits from the useful effects of this type of exercise.

VIEWS 3

Barnevholm P, Kuhl J, Pigon J. 2003. Insulin resistance in type 2 diabetes: Association with truncal obesity impaired fitness and a typical malonyl 1 Co enzyme a regulation. The Journal of Clinical Endocrinology & Metabolism 88(1), 82-87. http://dx.doi.org/10.1210/jc.2002-020330

Behre CJ. 2007. Adiponectin: saving the starvedand the over fed. Medical Hypotheses 56, 1198-1209.

Berggren JR, Hulver MW, Houmard JA. 2005. Fat  as  an  endocrine  organ:  influence  of  exercise. Journal of Applied Physiology 99, 757-64. http://dx.doi.org/10.1152/japplphysiol.00134.2005

Bluher M, Brennan AM, Kelesidis T. 2007. Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program; Comparative evaluationof three assays encoding. Endocrinology 6, 2900-2980.

Chan DC, Watts GF, Ng TW, Uchida Y, Sakai N, Yamashita S, Barrett PH. 2005. Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism. Clinical Chemistry 51, 578-85. http://dx.doi.org/10.1373/clinchem.2004.045120

Chevillotte E, Giralt M, Miroux B, Ricquier D, Villarroya F. 2007. Uncouplingprotein-2 controls adiponectin gene expressionin adipose tissue through the modulation of reactive oxygen speciesproduction. Diabetes 56, 1042-1050. http://dx.doi.org/10.2337/db06-1300

Coms TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M et al. 2004. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elenated circulating adiponectin and improved insulin sensitivity. Endocrinology 145, 367-83. http://dx.doi.org/10.1210/en.2003-1068

Davenport M.H, Mottola M.F, McManus R, Gratton R. 2008. A walking intervention improves capillary glucose control in women with gestational diabetes mellitus: a pilot study. Applied Physiology, Nutrition, and Metabolism 33(3), 511-7. http://dx.doi.org/10.1139/H08-018

Dimitrou R, Pauweber S, Bernhard. 2006. The effect  of  physical  activity  and  physical  fitness  on plasma adiponectin in adults with predispoisition to metabolic syndrome”. European Journal of Applied Physiology 98(5), 472-81. http://dx.doi.org/10.1007/s00421-006-0291-9

Donald K. Mathews, Edward L Fox. 2010. The Physiologycal Basis of Physical Education and Athletics. The University of Michigan.

Hisayo Y, Masanori E, Takahiro A. 2004. Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes. Metabolism endocrinology and molecular medicine. Diabetes care 27(7), 957-975. http://dx.doi.org/10.2337/diacare.27.7.1756

Hoffested J, Arviddson E, Sjo Lin E, Wahler N, Anner P. 2004. Adipose tissue adiponectin production and adiponectin serum concentration in human obesity and insulin resistance. Journal of Clinical Endocrinology & Metabolism 89(3), 1391-96. http://dx.doi.org/10.1210/jc.2003-031458

Hotta K, Funahashi T, Aritay. 2000. Plasma concentrations of a novel adipose specific protein adiponectin in type 2diabetic patients. Arteriosclerosis, Thrombosis, and Vascular Biology 20(6), 1595-9. http://dx.doi.org/10.1161/01.ATV.20.6.1595

Hu E, Liang P, Spiegelman BM. 1996. AdipoQ is anovel adipose specific gen deregulated in obesity. Journal of Biochemistry 271, 10696-10703.

Hu  G,  Rico-Sanz  J,  Lakka  Ta,Tumilehto  J. 2006. Exercise geneties and prevention of type 2 diabetes. Essays in Biochemistry 42, 177-192. http://dx.doi.org/10.1042/bse0420177

Ifigena GP, Bo Fernhall, Robert Carhal. 2005. Effects of deit and exercise on the of postmenauposal women with type 2 diabetes. Metabolism Clinical and Experimental 54, 866-875. http://dx.doi.org/10.1016/j.metabol.2005.01.033

Kadowaki Takshi, Yamuchi Toshimara. 2005. Adiponectin  and  adiponectin  receptors:  Endocrine Reviews 26(3), 439-451. http://dx.doi.org/10.1210/er.2005-0005

Kang I, Min Hwa Suk, Yan A Shin. 2007. Circulating adiponectin responses to acute and chronic exercise in obese women. The Faseb Journal 21, 765-773.

Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G. 2003. Adiponectin expression from human adipose tissue:relation to obesity, insulin resistance,  and  tumor  necrosis  factorα  expression. Diabetes 52, 1779-85. http://dx.doi.org/10.2337/diabetes.52.7.1779

Kershaw EE, Flier JS. 2004. Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology & Metabolism 89, 2548-56. http://dx.doi.org/10.1210/jc.2004-0395

Kobayashi J, Murase Y, Asano A, Nohara A, Kawashiri MA, Inazu A et al. 2006. Effect of Walking with a pedometer on serum lipid and adiponectin levelsnin Japanese middle aged men. Journal of atherosclerosis and thrombosis 3, 197-201. 27.

Koh EH, Park JY, Park HS, Jeon MJ, Ryu JW, Kim M et al. 2007. Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes 56(12), 2973-81. http://dx.doi.org/10.2337/db07-0510

Kraemer RR, Castracane D. 2007. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Experimental Biology and Medicine 232(2), 184-194.

Lambers S, Van Laethem C, Van Acker K, Calders P. 2008. Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clinical Rehabilitation 22, 483-92. http://dx.doi.org/10.1177/0269215508084582

Luccotti P, Setola E, Monti L. 2006. Beneficial effects of a long term oral L-arginine treatment added to a hypocaloric deit and exercise training program in obese insulin resistant type 2 diabetic patients”. American Journal of Physiology – Endocrinology and Metabolism 291(5), 906-12. http://dx.doi.org/10.1152/ajpendo.00002.2006

Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. 2004. Adiponectin and the metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 29-33. http://dx.doi.org/10.1161/01.ATV.0000099786.9962 3.EF

Misra A, Alappan NK, Vikram NK. 2008. Effect of supervised progressive resistance- exercise training protocol on insulin sensitivity, glycemia, lipids, and body compositionin Asian Indians with type 2 diabetes. Diabetes care 31, 1282-7. http://dx.doi.org/10.2337/dc07-2316

Nemet D, Wang P, Funahashi T. 2003. Adipocytokines body composition and fitnessin children. Pediatric Research 53, 148-52. 29.

Pittas AG, Joseph NA, Greenberg AS. 2004. Adipocytokines and insulin resistance. Journal of Clinical Endocrinology and Metabolism 89, 447-52. http://dx.doi.org/10.1210/jc.2003-031005

Stefan NB, Vozarova T, Funahashi Y, Matsuzawa C, Weyer RS, Lindsay JF et al. 2002. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes decrease in whole body insulin sensitivityin humans. Diabetes 51(6), 1884-8. http://dx.doi.org/10.2337/diabetes.51.6.1884

Stejskal D, Ruzicka V, Adamovska S. 2003. Adiponectin concentration as a criterion of metabolic control in person with type 2 diabetes mellitus? Biomedical Papers 147, 167-72. http://dx.doi.org/10.5507/bp.2003.023

Stephan FE, Luc JC. Van Loon. 2007. Optimizing the therapeutic benefits of exercise in type 2 diabetes. Journal of Applied Physiology 103, 1113-1120. http://dx.doi.org/10.1152/japplphysiol.00566.2007

Tso TK, Huang WN, Huang HY, Chang CK. 2006. Elevation of plasma interlukin-18 concentration  is  associated  with  insulin  resistance levels in patients with systemic lupus erythematosus. Lupus 15(4), 207-12. http://dx.doi.org/10.1191/0961203306lu2284oa

Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S et al. 2004. Insulin/foxo 1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. Journal of Biological Chemistry 279(29), 30817-22. http://dx.doi.org/10.1074/jbc.M402367200

Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA. 2001. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. Journal of Clinical Endocrinology & Metabolism 86, 1930-35. http://dx.doi.org/10.1210/jc.86.5.1930

Yamauchi T, Kamon J, Waki H. Terauchi Y, Kubota N, Hara K, Mori Y. 2001. The fat derived hormone adiponectinreverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 7(8), 941-46. http://dx.doi.org/10.1038/90984

Yu Wang, Karen SL. Lam XU. 2006. Adiponectin as a therapeutic target for obesity-related metabolic and cardiovascular disorders. Journal of Pharmaceutical Sciences 96, 57-84.

Zeng Q, Fu L, Takekoshi K, Kawakami Y, Isobe k. 2007. Effect of short term exercise on adiponectin and adiponectin receptor levels in rats. Journal of atherosclerosis and thrombosis 14, 261-5. http://dx.doi.org/10.5551/jat.E498