Welcome to International Network for Natural Sciences | INNSpub

Effect of blood electrolytes in hypertensive and heart attack patients

Research Paper | November 1, 2019

| Download 10

Aamir Khan Awan, Yar Muhammad Khan, Matiullah, Rahmat Ali Khan, Khayal Muhammad

Key Words:

Int. J. Biosci.15( 5), 1-8, November 2019

DOI: http://dx.doi.org/10.12692/ijb/15.5.1-8


IJB 2019 [Generate Certificate]


A number of electrolytes are involved in the regulation of blood pressure (BP) and the pathophysiology of heart attack (HA).  In present study, we have studied blood sodium (Na), calcium (Ca) and potassium (K) concentration in hypertensive and heart attack patients. Our hypothesis was that whether the hypertensive and heart attack patients have high levels of Na+, Ca+2 and K+2. Twenty five (25) patients of heart attack, twenty five (25) patients of hypertension and 10th control healthy individuals were randomly selected from blood sampling. Informed consent was taken from each patient before sampling, blood was centrifuged and plasma was separated. Flam photometer was used to analyze electrolytes concentration in these samples. Unpaired t-test was used for statistical analysis. Statistical analysis has shown that sodium (Na) and potassium (K) shows more significant deference in in hypertensive patients (BP), and less significant in heart attack (HA) patients. Similarly Calcium (Ca) shows less significant in hypertensive patients (BP) and heart attack (HA) patients. In the light of our experiment, we conclude there that increase of sodium (Na) in blood may cause to rise blood pressure which lead to risk of  hearts attack, In balance conditions potassium (K) and calcium (Ca) have role in maintenance of normal blood pressure. However there is no conclusive and correct statement about calcium in this respect. In current studies, it was suggested that the unbalance condition of sodium (Na) and potassium (K) may increase risk factors of BP and heart attack patients.


Copyright © 2019
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Effect of blood electrolytes in hypertensive and heart attack patients

Azizi F, Ghanbarian A, Madjid M, Rahmani M. 2002. Distribution of blood pressure and prevalence of hypertension in Tehran adult population: Tehran Lipid and Glucose Study (TLGS), 1999–2000. Journal of human hypertension 16(5), p 305.

Barrett-Connor E, Khaw K. 1985. Is hypertension more benign when associated with obesity? Circulation 72, 53-60.

Bloch MJ, Fash F, Basile FJ. 2001. Cardiovascular risks of hypertension.

Capasso G, Unwin R. 2011. Electrolytes and acid–base: common fluid and electrolyte disorders. Medicine 39, 317-324.

He F, Macgregor G. 2003. Cost of poor blood pressure control in the UK: 62 000 unnecessary deaths per year. Journal of human hypertension 17, 455-457.

Hwang SJ, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, Gotto AM, Boerwinkle E. 1997. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases the Atherosclerosis Risk In Communities (ARIC) study. Circulation 96, 4219-4225.

Kesteloot H, Park B, Lee C, Brems-Heyns E,  Joossens J. 1980. A comparative study of blood pressure and sodium intake in Belgium and in Korea. Epidemiology of arterial blood pressure. Springer.

Kotchen TA, Mccarron DA, Committee N. 1998. Dietary electrolytes and blood pressure a statement for healthcare professionals from the American Heart Association Nutrition Committee. Circulation 98, 613-617.

Lee JW. 2010. Fluid and electrolyte disturbances in critically ill patients. Electrolytes & Blood Pressure 8, 72-81.

Li JJ, Fang CH, Hui RT. 2005. Is hypertension an inflammatory disease? Medical hypotheses 64, 236-240.

Lifton RP, Gharavi AG, Geller DS. 2001. Molecular mechanisms of human hypertension. Cell, 104, 545-556.

Lobo DN, Lewington AJ, Allison SP. 2013. Basic concepts of fluid and electrolyte therapy. Bibliomed, Melsungen.

Meneely GR, Battarbee HD. 1976. High sodium- low potassium environment and hypertension. The  American journal of cardiology 38, 768-785.

Musso CG. 2009. Magnesium metabolism in health and disease. International urology and nephrology, 41, 357-362.

Pravina P, Sayaji D, Avinash M. 2013. Calcium and its role in human body. International Journal of  Research in Pharmaceutical and Biomedical Science 4(2), p 659-668.

Rana S, Karumanchi SA, Lindheimer MD. 2014. Angiogenic factors in diagnosis, management, and research in preeclampsia. Hypertension 63, 198-202.

Riaz K, Forker A, Ahmed A. 2007. Hypertensive heart disease. Retrieved online August, 22, 2009.

Ridker PM, Morrow DA. 2003. C-reactive protein, inflammation, and coronary risk. Cardiology clinics, 21, 315-325.

Rose BD. 1977. Clinical physiology of acid-base and electrolyte disorders, McGraw-Hill.

Simonetti G, Mohaupt M. 2007. Calcium and blood pressure. Therapeutische Umschau. Revue therapeutique 64(5), p 249-252.

Skorecki K, Ausiello D. 2011. Disorders of sodium and water homeostasis. Goldman L, Schafer AL. Goldman’s Cecil medicine. Philadelphia, PA: Saunders, Elsevier, 720-34.

Tobian L. 1960. Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiological reviews 40, 280-312.

Turban S, Thompson CB, Parekh RS, Appel LJ. 2013. Effects of sodium intake and diet on racial differences in urinary potassium excretion: results from the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial. American Journal of Kidney Diseases 61, 88-95.