Effect of chronic aluminum chloride toxicity on sperm and reproductive markers in albino mice
Paper Details
Effect of chronic aluminum chloride toxicity on sperm and reproductive markers in albino mice
Abstract
There is a little indication that aluminum is acutely toxic for the general population but prolonged exposure may induce systemic toxicity affecting the gastrointestinal tract, brain or skeleton. Therefore, the present study was conducted to investigate the effect of chronic aluminum chloride toxicity on sperm and some reproductive markers in Albino mice. A total of 24 mice each were injected an IP sub-chronic dose of 55.45mg/kg IP, or saline (control) daily for 60 consecutive day. After the 7th, 15th and 30ty 60ty day of dosing, mice were sacrificed for sperm counts and quality and microscopy of testis, prostrate and epididymis. The study showed that the effect increased with increasing ALCl3 dose and duration of exposure. The study also showed significant (P<0.05) increasing in the rates of birth defects in sperm with a significant decrease (P <0.05) in the preparation of her natural and special periods (30,60) for the chronic toxic Exposure. As explained microscopic examination of scarified mice ranged from pathological lesions which was getting over exposed began toxic degeneration of cellular necrosis in the cells of members with hemorrhage and congestion and the disappearance of the evolution of sperm, and infiltrates of inflammatory cells (lymphocytes and macrophages).
Adebayo AB, Samuel AO, Joseph OH, Sunday SA. 2012. Aluminium chloride exposure had no effects on the epididymis of Wistar rats. American Medical Journal 3(2), 210-219.
Agrawal SK, Ayyash L, Gourley CS, Levy J, Faber K, Hughes CL. 1996. Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium. Food Chemical Toxicology 34, 49-53.
Alleva E, Rankin J, Santucci D. 1998. Neurobehavioral alteration in rodents following developmental exposure to aluminum. Toxicology and Industrial Health 14(1–2), 209 – 221.
ATSDR. 1997. Toxicological Profile for Aluminum (Update). Draft for public comment. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services. Atlanta, GA.
Bownan WC, Rand MJ. 2000. Text Book of Pharmacology, 2nd ed., Bowman and William Cameron, Great Britain by University press, Cambridge
Bray JJ, Cragg PA, Macknight ADC, Mills RG. 2012. Reproduction, In: Huamn physiology, Bray, J.J., Cragg, P.A., Mack night, A.D.C. and Mills, R.G. (eds), 4th ed., Blackwell Science, USA, Pp, 274.
Buraimoh AA, Ojo SA, Hambolu JO, Adebisi SS. 2012a. Brain aluminium uptake of adult wistar rats following the oral administration of aluminium chloride. European Journal of Scientific Research 72, 576-582.
Chinoy NJ, Trupti N, Patel A. 2001. Effects of sodium fluoride and aluminium chloride on ovary and uterus of mice and their reversal by some antidotes. Fluoride 34(1), 9-20.
Colomina MT, Esparza JL, Corbella J, Domingo JL. 1998. The effect of maternal restraint on developmental toxicity of aluminium in mice. Neuro toxicology and Teratology 20, 651-656.
El-demerdash FM. 2004. Antioxidant effect of vitamin E and selenium on lipid peroxidation, enzyme activities and biochemical parameters in rats exposed to aluminum. Journal of Trace Elements and Medical Biology 18, 113-121.
Gil-Guzman E, Ollero M, Lopez MC, Sharma RK, Alvarez JG, Thomas AJ Jr, Agarwal A. 2002. Differential production of reactive oxygen speciesby subsets of human spermatozoa at different stages of maturation. Human Reproduction 16, 1922–1930.
Farina M, Lara FS, Brandao R, Jacques R, Rocha JBT. 2002. Effects of aluminum sulfate on erythropoiesis in rats. Toxicology Letter 132, 131-139.
Flaten R. 2001. Absorption of aluminum from antiperspirants and vaccine adjuvants. In″ Aluminum and Alzheimer’s Diseases : The Science that Describes the link. ″ (C. Exley, Ed), p 75–95. Elsevier. Amsterdam.
Goel KA, Sastry KV. 1997. A Text Book of Animal Physiology, Rakesh Kumar Rastogi, India p, 443.
Golub MS, Germann SL. 1997. Aluminum effects on operant performance and food motivation of mice. Neurotoxicology and Teratology 20(4), 421 – 427.
Issam M, Ahmed E, Khamas WA. 2005. Evaluation of reproductive and fertility toxic potential of ALCL3 on adult male mice. Journal of Animal and Veterinary Advances 4(2), 224-233.
Jones TC, Hunt RD. 1983. Veterinary Pathology Leo & Febiger. Philadelphia, p 167.
Kachny W, Hegg A, Alfrey A. 1997. Gastrointestinal absorption of aluminium from aluminium containing antacids. New England Journal of Medicine 296, 1389-1390.
Khattab IKF. 2007. Histological and ultra structural studies on the testis of rat after treatment with aluminium chloride. Australian Journal of Basic Applied Science 1, 63-72.
Liobet JM, Colomina MT, Sirvent JJ, Domingo JL, Corbella J. 1995. Reproductive toxicology of aluminium in male mice. Fundamental Applied Toxicology 25 (1), 45-51 .
Luna GL. 1968. Manual of Histologic staining methods of the armed forces Institute of Pathology. 3rd edition. McGraw-Hill Book Company, New York, USA.
Mayyas I, Elbetieha A, Khamas W, Khamas A. 2005. Evaluation of reproductive and fertility toxic potentials of aluminium chloride on adult male mice, Journal of Animal and Veterinary Advances 4(2), 224-233.
Mohammad AM. 2014. Toxicopathological Effect of Aluminum Chloride (ALCL3) in Male and Female Reproductive System of Albino Mice. M. Sc. thesis, College of Veterinary Medicine Baghdad University.
Ollero M, Gil-Guzman E, Lopez MC, Sharma RK, Agarwal A, Larson K, Evenson D, Thomas AJJR, Alvarez JG. 2001. Characterization of subset of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. Human Reproduction, 16, 1912–1921.
Pizent A, Tariba B, Živković T. 2012. Reproductive toxicity of metals in men, Archives of Industrial Hygiene and Toxicology 63, 35-46
Ranjbar AR, Khani-Jazani A, Sedighi F, Jalali-Mashayehi M, Ghazi-Khansari, Abdollahi M. 2008. Alteration of body total antioxidant capacity and thiol molecules in human chronic exposure to aluminum. Toxicology and Environmental Chemistry 90, 707-713.
SAS. 2012. Statistical Analysis System, User’s Guide. Statistical. Version 9.1th ed. SAS. Inst. Inc. Cary. N.C. USA.
Sharma P, Shah ZA, Kumar A, Islam F, Mishra KP. 2007. Role of combined administration of Tiron and glutathione against aluminum-induced oxidative stress in rat brain. Journal of Trace Elements and Medical Biology 2163–70.
Summaedaey AS. 1989. Experimental Study of Mercurical Toxicosis in Rats. Iraqi Journal of Veterinary Med 36(2), 231– 243.
Ward RJ, Zhang Y, Crichton RR. 2001. Aluminum toxicity and iron homeostasis. Journal of Inorganic Biochemistry 87(1-2), 9-16.
WHO. 1997. Aluminium. Geneva, World Health Organization, International Programmer on Chemical Safety (Environmental Health Criteria 194.
Yousef MI. 2004. Aluminum-induced changes in hemato-biochemical parameters, lipid peroxidation and enzyme activities of male rabbits: protective role of ascorbic acid. Toxicology 199, 47-57.
Yousef MI, Salama AF. 2009. Propolis protection from reproductive toxicity caused by aluminium chloride in male rats. Food Chem. Toxicology 47, 1168-1175.
Yousef MI, El-Morsy AM, Hassan MS. 2005. Aluminum-induced deterioration in reproductive performance and seminal plasma biochemistry of male rabbits: Protective role of ascorbic acid. Toxicology 215, 97-107. http://dx.doi.org/10. 1016/j.tox. 06. 025.
Anfal Mahdi Mohammed, Bushra Ibrahim AL-Kaisei, Taghreed Jabbar Humadai, Eman Hasham Al-Taee, 2018. Effect of chronic aluminum chloride toxicity on sperm and reproductive markers in albino mice. Int. J. Biosci., 13(5), 103-112.
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