Effect of chronic aluminum chloride toxicity on sperm and reproductive markers in albino mice

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Research Paper 01/11/2018
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Effect of chronic aluminum chloride toxicity on sperm and reproductive markers in albino mice

Anfal Mahdi Mohammed, Bushra Ibrahim AL-Kaisei, Taghreed Jabbar Humadai, Eman Hasham Al-Taee
Int. J. Biosci.13( 5), 103-112, November 2018.
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There is a little indication that aluminum is acutely toxic for the general population but prolonged exposure may induce systemic toxicity affecting the gastrointestinal tract, brain or skeleton. Therefore, the present study was conducted to investigate the effect of chronic aluminum chloride toxicity on sperm and some reproductive markers in Albino mice. A total of 24 mice each were injected an IP sub-chronic dose of 55.45mg/kg IP, or saline (control) daily for 60 consecutive day. After the 7th, 15th and 30ty 60ty day of dosing, mice were sacrificed for sperm counts and quality and microscopy of testis, prostrate and epididymis. The study showed that the effect increased with increasing ALCl3 dose and duration of exposure. The study also showed significant (P<0.05) increasing in the rates of birth defects in sperm with a significant decrease (P <0.05) in the preparation of her natural and special periods (30,60) for the chronic toxic Exposure. As explained microscopic examination of scarified mice ranged from pathological lesions which was getting over exposed began toxic degeneration of cellular necrosis in the cells of members with hemorrhage and congestion and the disappearance of the evolution of sperm, and infiltrates of inflammatory cells (lymphocytes and macrophages).


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