Effect of illicit drugs and alcoholism on cardiac enzymes

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Research Paper 01/07/2019
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Effect of illicit drugs and alcoholism on cardiac enzymes

Muhammad Jaseem Khan, Heena Bibi
Int. J. Biosci.15( 1), 542-547, July 2019.
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Abstract

The use of illicit drugs is spread worldwide. Drugs have serious effect on human health and in many cases deadly. It damage cardiac tissues and release cardiac enzymes due to injury/damage to it. Main objective of the study was to evaluate the effect of illicit drugs on cardiac enzymes and to know the correlation of single drug, double drugs, triple drugs and multiple drugs effect on cardiac enzymes. A study was conducted in the Institute of Paramedical Sciences Khyber Medical University Peshawar. For CK and LDH estimation, 183 male illicit drug users and for CKMB 107 were recruited. Control group were also taken with same age group, number and population. The patient blood samples were tested for LDH, CK and CKMB by Chemistry analyzer AMP. The statistical analysis was carried out using paired t-sample test. After analysis our study revealed that illicit drug abuse has sufficient influence on cardiac enzymes and multiple drugs using reinforced elevation in cardiac enzymes. These findings indicated of myocardial tissue damage with comparison in control groups. Illicit drugs lead to heart muscles damaged and caused release of elevated level of cardiac enzymes.

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Agrawal PR, Scarabelli TM, Saravolatz L, Kini A, Jalota A, Chen-Scarabelli C, Fuster V, Halperin JL. 2015. Current strategies in the evaluation and management of cocaine-induced chest pain. Cardiology in review 23(6), pp.303-311.

Ambrose JA, Barua RS. 2004. The pathophysiology of cigarette smoking and cardiovascular disease: an update. Journal of the American college of cardiology 43(10), pp.1731-1737.

Amin M, Gabelman G, Karpel J, Buttrick P. 1990. Acute myocardial infarction and chest pain syndromes after cocaine use. The American journal of cardiology 66(20), pp.1434-1437.

Anbarasi K, Vani G, Balakrishna K, Devi CS. 2005. Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of Bacoside A. Vascular pharmacology 42(2), pp.57-61.

Ballester M, Martí V, Carrió I, Obrador D, Moya C, Pons-Lladó G, Bernà L, Lamich R, Aymat MR, Barbanoj M, Guardia J, 1997. Spectrum of Alcohol-Induced Myocardial Damage Detected by Indium-111–Labeled Monoclonal Antimyosin Antibodies. Journal of the American College of Cardiology 29(1), pp.160-167.

Bolinder G, Alfredsson L, Englund A, De Faire U. 1994. Smokeless tobacco use and increased cardiovascular mortality among Swedish construction workers. American Journal of Public Health 84(3), pp.399-404.

Dwivedi S, Kumar V, Aggarwal A. 2008. Cannabis smoking and acute coronary syndrome: two illustrative cases. International journal of cardiology 128(2), pp.e54-e57.

Filippidis FT, Vardavas CI, Loukopoulou A, Behrakis P, Connolly GN, Tountas Y. 2012. Prevalence and determinants of tobacco use among adults in Greece: 4 year trends. The European Journal of Public Health 23(5), pp.772-776.

Ghuran A, Nolan J. 2000. Recreational drug misuse: issues for the cardiologist. Heart 83(6), pp.627-633.

Hoda SA, Hoda RS. 2005. Robbins and cotran pathologic basis of disease. Advances in Anatomic Pathology 12(2), p.103.

Hollander JE, Hoffman RS, Burstein JL, Shih RD, Thode HC, Bartfield J, Raccio-Robak N, Harchelroad F, Nelson L, Sandoval M, Feldman J. 1995. Cocaine-associated myocardial infarction: mortality and complications. Archives of Internal Medicine 155(10), pp.1081-1086.

Jaffe AS, Landt Y, Parvin CA, Abendschein DR, Geltman EM, Ladenson JH, 1996. Comparative sensitivity of cardiac troponin I and lactate dehydrogenase isoenzymes for diagnosing acute myocardial infarction. Clinical chemistry  42(11), pp.1770-1776.

de los Ríos F, Kleindorfer DO, Khoury J, Broderick JP, Moomaw CJ, Adeoye O, Flaherty ML, Khatri P, Woo D, Alwell K, Eilerman J. 2012. Trends in substance abuse preceding stroke among young adults: a population-based study. Stroke 43(12), pp.3179-3183.

Lavery LA, Peters EJG, Bush R. 2010. High Risk Diabetic Foot: Treatment and Prevention. CRC Press.

Nagaraju K. 2009. Inflammatory diseases of muscle and other myopathies. Kelley’s textbook of rheumatology pp.1353-1380.

Phillips K, Luk A, Soor GS, Abraham JR, Leong S, Butany J. 2009. Cocaine cardiotoxicity. American journal of cardiovascular drugs 9(3), pp.177-196.

Rashid S, Khawaja TF, Khurshid R. 2010. Early and long term predictive value of cardiac marker troponin T and CK-MB in acute myocardial infarction. Pakistan Journal of Physiology 6(2), pp.43-45.

Rasmussen JE, Sheridan JT, Polk W, Davies CM, Tarran R. 2014. Cigarette smoke-induced Ca2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. Journal of Biological Chemistry 289(11), pp.7671-7681.

Tomlinson MF, Brown M, Hoaken PN. 2016. Recreational drug use and human aggressive behavior: A comprehensive review since 2003. Aggression and violent behavior 27, pp.9-29.

UNODC. 2011. World drug report 2011, United Nations Office on Drugs and Crime. doi: 10.1007/s12117-997-1166-0.

Urbano-Márquez A, Estruch R, Fernandez-Sola J, Nicolás JM, Pare JC, Rubin E. 1995. The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. Jama 274(2), pp.149-154.

World Health Organization. 2013. WHO Report on the Global Tobacco Epidemic, WHO Report on the Global Tobacco Epidemic. doi: 10.1002/aehe. 3640230702.

Calhoun DA, Nishizaka MK, Zaman MA, Thakkar RB, Weissmann P. 2002. Hyperaldosteronism among black and white subjects with resistant hypertension. Hypertension 40(6), pp.892-896.