J. Bio. Env. Sci.3(12), 277-282, December 2013
Obestatin is a 23-Amino Acid peptide which secreted from the fundus of stomach and can play an important role in regulation of food receiving and body weight. The aim of the present study was to investigate the Effect of moderate and high intensity aerobic exercise training on plasma levels of obestatin in male wistar rats. Nineteen male Wistar rats (8 weeks old, 200 to 225 g) randomly divided to control and training. After two weeks of familiarization speed and time gradually increased to determined intensity for each group. Aerobic training program included 8 weeks, 5 sessions per week for 60 min. the intensity of the exercise was 80% – 85% VO2max for high intensity training group (HIT group) and 70% – 75% VO2max for moderate intensity training group (MIT group). Rats were anesthetized intraperitoneally fourty-eight hours after the final training session (after 12 h fasting), and Blood samples was collected directly from the right ventricle. The mean weight in HIT group reduced significantly than to control group. Plasma obestatin levels didn’t have any significant differences between these three groups. However the obestatin levels in Exercise training groups were higher than control group.
Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, Small CJ, Carling D. 2005. Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity. Biochemical and Biophysical Research Communications 329(2), 719-25.
Bresciani E, Rapetti D, Dona F, Bulgarelli I, Tamiazzo L, Locatelli V. 2006. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. Journal of Endocrinological Investigation 29(8), 16-8.
Broglio F, Prodam F, Riganti F, Muccioli G, Ghigo E. 2006. Ghrelin: from somatotrope secretion to new perspectives in the regulation of peripheral metabolic functions. Frontiers of hormone research 35, 102-14.
Brunetti L, Di Nisio C, Recinella L, Orlando G, Ferrante C, Chiavaroli A. 2010. Obestatin inhibits dopamine release in rat hypothalamus. European Journal of Pharmacology 641(2-3), 142-7.
Dun SL, Brailoiu GC, Brailoiu E, Yang J, Chang JK, Dun NJ. 2006. Distribution and biological activity of obestatin in the rat. Journal of Endocrinology 191(2), 481-9.
Ghanbari-Niaki A, Jafari A, Abednazari H, Nikbakht H. 2008. Treadmill exercise reduces obestatin concentrations in rat fundus and small intestine. Biochemical and Biophysical Research Communications 372, 741-5.
Guo ZF, Ren AJ, Zheng X, Qin YW, Cheng F, Zhang J. 2008. Different responses of circulating ghrelin, obestatin levels to fasting, re-feeding and different food compositions, and their local expressions in rats. Peptides 29(7), 1247-54.
Guo ZF, Zheng X, Qin YW, Hu JQ, Chen SP, Zhang Z. 2007. Circulating preprandial ghrelin to obestatin ratio is increased in human obesity. Journal of Clinical Endocrinology & Metabolism. 92(5), 1875-80.
Hanbari-Niaki A, Soltani R, Shemshaki A, Kraemer RR. 2010. Effect of acute ethionine injection on plasma ghrelin and obestatin levels in trained male rats. Metabolism. 59, 982.
Harada T, Nakahara T, Yasuhara D, Kojima S, Sagiyama K, Amitani H, Laviano A. 2008. Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in therestricting type of anorexia nervosa. Biological Psychiatry. 63(2), 245-7.
Hillebrand JJ, de Wied D, Adan RA. 2002. Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides 23, 2283– 306.
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. 1999. Ghrelin is a growthhormone-releasing acylated peptide from stomach. Nature 402(6762), 656-60.
Kraemer RR, Castracane VD. 2007. Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Experimental Biology and Medicine (Maywood) 232, 184-94.
Lagaud GJ, Young A, Acena A, Morton MF, Barrett TD, Shankley NP. 2007. Obestatin reduces food intake and suppresses body weight gain in rodents. Biochemical and Biophysical Research Communications 357(1), 264-9.
Lagaud GJ, Young A, Acena A, Morton MF, Barrett TD, Shankley NP. 2007. Obestatin reduces food intake and suppresses body weight gain in rodents. Biochemical and Biophysical Research Communications 357, 264-9.
Murakami T, Shimomura Y, Fujitsuka N, Sokabe M, Okamura K, Sakamoto S. 1997. Enlargement glycogen store in rat liver and muscle by fructose-diet intake and exercise training. Journal of Applied Physiology. 82(3), 772-5.
Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A. 2007. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 148, 21-6.
Reinehr T, De Sousa G, Roth CL. 2008. Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweight. Clinical Endocrinology (Oxf). 68(2), 304-10.
Sedlácková D, Dostálová I, Hainer V, Beranová L, Kvasnicková H, Hill M. 2008. Simultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women. Physiological Research 57(Suppl 1), 29-37.
Tang SQ, Jiang QY, Zhang YL, Zhu XT, Shu G, Gao P. 2008. Obestatin: its physicochemical characteristics and physiological functions. Peptides 29(4), 639-45.
Unniappan S, Speck M, Kieffer TJ. 2008. Metabolic effects of chronic obestatin infusion in rats. Peptides 29(8), 1354-61.
Wang J, Chen C, Wang RY. 2008. Influence of short-and long-term treadmill exerciseson levels of ghrelin,obestatin and NPY in plasma and brain extraction of obese rats. Endocrine 33(1), 77-83.
Woods SC, Benoit SC, Clegg DJ, Seeley RJ. 2004. Clinical endocrinology and metabolism. Regulation of energy homeostasis by peripheral signals. Best Practice & Research Clinical Endocrinology & Metabolism 18, 497- 515.
Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C. 2005. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science 310(5750), 996-9.
Zhang JV, Ren PJ, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C. 2005. Obestatin, apeptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake, Aj Science 310(5750), 996-9.
Zou CC, Liang L, Wang CL, Fu JF, Zhao ZY. 2009. The change in ghrelin and obestatin levels in obese children after weight reduction. Acta Paediatric. 98, 159-65.