Effect of the silver nanoparticles on the histology of albino lactating mice ovaries

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Research Paper 01/08/2018
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Effect of the silver nanoparticles on the histology of albino lactating mice ovaries

Noor Mahdi, Gazwa D. Al-Nakeeb
J. Biodiv. & Environ. Sci. 13(2), 68-75, August 2018.
Copyright Statement: Copyright 2018; The Author(s).
License: CC BY-NC 4.0

Abstract

There is increasing interest and need to develop a deeper understanding of the nature, fate and behavior of nanoparticles in the environment. This is driven by the increased use of nanoparticles and the increased pressure to commercialize this growing technology. Silver nanoparticles (Ag NPs) are the most commonly nanoparticles used in various areas of research, because of their characteristic physical as: magnatic, mechanical: performance as well as antimicrobial effects as antiviral, antibacterial , so that exposure human to increase levels of nanoparticles. Therefore, this study aimed to investigate the histological effects of silver nanoparticles exposure on the ovary of the lactating albino mice. Sixty adult lactating female albino mice were divided into three main groups of (15) females exposed to 1p.p.m., (15) females were exposed by 1.5p.p.m. , (15) females were exposed to 2p.p.m. of silver nanoparticles solution for 7, 14  and 21 days as well as 3 control groups each group 5 mice contain by intra-peritoneal injection.  After the end of injection periods the samples of animals were sacrificed and dissected to remove the ovaries and kept in Bouins fluids for microscopic examination treated groups exhibited  different histopathological changes ,depending on the concentration of silver nanoparticles as : hyaline degeneration, hydropic degeneration, fibrous necrosis, and  on the period of exposure, these changes include shrinkage of Oocyte, fatty degeneration, amyloid protein precipitation, pyknosis , necrosis ,cloudy degeneration, fusion and swelling cells, Caceous necrosis different damage  effects  in silver accumulations was noted in the  ovary, with accumulations being significantly higher in female lactating mice, especially in the  cortex, follicles, stroma.

Abou El–Nour KMM, Eftaiha A, Al  Warthan A. 2010. Synthesis and applications of Silver nanoparticles. Arabian journal of chemistry 3(3), 135-140.

Wijnhoven SWP, Peijnenburg WJGM, Herberts CA, Hagens WI, Oomen AG, Heugens EHW, Roszek B, Bisschops J, Gosens I, Van De Meent D. 2009. Nano-silver, A review of available data and knowledge gaps in human and environmental risk assessment. Nano Toxicology 3, 109–138.

Rai M, Deshmukh SD, Ingle AP, Gupta IR, Galdiero M, Galdiero S. 2016. Metal nanoparticles: the protective Nano shield against virus infection. Crit. Rev. Microbiology 42(1), 46-56. PMID: 24754250 http://dx.doi.org/10.3109/1040841X2013.879849

Yih TC, Wei TC. 2005. Nanomedicine in cancer treatment. Nano medicine: Nanotechnology, Biology, and Medicine 1, 191-192.

Zhong W, Xing MM, Maibach HI. 2010. Nano fibrous  materials for wound care. Cutan. Ocul. Toxicology 29(3), 143- 152.

Panyala NR, Pena-Mendez EM, Havel J.  2008 . Silver or Silver Nanoparticles: A Hazardous Threat to the Environment and Human Health. Journal of Applied Biomedicine 6, 117-129.

Yoshida K, Tangagawa M, Matsumoto S, Yamada T, Atsuta M. 1999. Antibacterial activity of resin composites with silver containing materials. European Journal of Oral sciences 107(4), 290 -296.

Donner A. 2010. Nanotechnology in molecular medicine trends in molecular medicine. ESof 16(12), 551 -552.

Trop M, Novak M, Rodl SL, Lellbom B, Kroell W, Goessler W. 2006. Silver coated dressing Acticoat caused  raised liver enzymes and Argyria like symptoms in burn patient. J. Trauma 60, 648- 655.

Bancroft JD, Steven AS. 2012. Theory and practice of histological techniques. 2nd ed. Churchill living stone, Edinburgh, London: 233-250.

Sardari RRR, Zarchi SR, Talebi A, Wang S, Wang J, Liu LJ, Li J, Yuan F, Lu S, Wan Z, Chou L, Xi T. 2012. Toxicological effects of silver nanoparticles in rats. Afr. J.  Microbiology Research 6(27), 5587- 5593.

Attia A, A. 2014. Evaluation of the testicular alterations induced by silver nanoparticles in   male mice : Biochemical , Histological and   ultra structural studies. Research Journal of Pharmaceutical, Biological and Chemical Sciences 5(4), 1558-1589.

Gavanji S, Sayedipour SS, Doost mhammdi M, Larki B. 2014. The effect of different concentration of silver nanoparticles on enzyme activity and liver tissue of adult male wistar rats in vivo condition. I.I.S.R.K, 4(2), 182-188.

Stevens A, Lowe J, Scott I, Damjanov I. 2009. Core Pathology .3th ed . Elsevier. China: 442-443.

Kumar V, Abbas AK, Fausto N, Mitchell RN. 2007. Robbins Basic Pathology .8th ed .John F. Kennedy Blvd. Philadelphia , USA: 85-86.

Altunkaynak BZ, Akgul N, Yahyazadeh A,  Altunkaynak ME, Turkmen AP, Akgul HM. Unal B. 2016. Effect of mercury vapor inhalation on rat ovary: Sterology  and histopathology. J. Obstet Gynaecol , Research 42(4), 410-416.

Robbin SSL, Kumar V. 1987. Basic Pathology .4 th Ed Saunders Company, Phildelphia , London, 787.

Bhattacharya GK. 2016.Concise pathology for exam preparation . 3rd Elsevier. RELX India, 14-15.

Sundriter W, Thomas C. 1979. Color Atlas and Textbook of Histopathology. 6th Ed. Sand Ritter, Walter. USA, 225.

Al zahid AA,  Faris KJ, Kodiar OS. 2015. Histopathological study of the toxic doses of Clove Oil Syzygium aromaticum on ovaries of female rabbits. IOSR-JAVS 8(8), 33-38.

Zhang S, Du C, Wang Z, Han X, Zhang K, Liu L. 2013. Reduced cytotoxicity of silver ions to mammalian cells at high concentration due to the formation of silver chloride. Toxicol. In vitro 27, 739–744. [PubMed].

Hadrup N, Lam HR. 2014. Oral toxicity of silver ions, silver nanoparticles and colloidal silver—a review. Regul. Toxicol. Pharmacology 68, 1–7. [PubMed[

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