Effect of thiamine on blood glucose changes after maximal aerobic exercise in non-athlete university students male

Paper Details

Research Paper 01/08/2014
Views (209) Download (8)
current_issue_feature_image
publication_file

Effect of thiamine on blood glucose changes after maximal aerobic exercise in non-athlete university students male

J.R. Mehdi Kasbparast, Alireza Rahimi, Omid Yaghoobpour Yekani, Mehdi Rezaei
J. Bio. Env. Sci.5( 2), 591-597, August 2014.
Certificate: JBES 2014 [Generate Certificate]

Abstract

This study is conducted with the aim of investigating the effect of vitamin B1 (Thiamine) on blood glucose changes. We observed that when the subjects received 300 mg thiamin /day, there was a lowering of blood glucose level after physical activity. Like the other B vitamins, thiamin is used to treat fatigue. High-dose thiamin supplementation may be helpful in preventing fatigue or accelerating recovery from exercise-induced fatigue. In this research 36 non-athlete university students male were selected with average 22.8±2.4, 174.19±4.67, 76.34 ± 5.36 and 42.36 ± 1.83 for age, height, weight and Vo2max respectively,(12 persons in each group).The subjects placed in three groups: Experimental Group A(EGA),Experimental Group B(EGB) and Control Group(CG).They have to exercise on treadmill before and after the thiamin consumption. First of all, blood glucose measured in three groups before exercise and then performed exercise on treadmill until exhaustion. Blood glucose changes in subjects measured by (GOD-PAP method) after the exercise (pre-test).The subject’s consumed thiamin during 10 days (EGA 30 mg /day, EGB 300 mg/day and CG just placebo) Blood glucose changes measured in three groups like as pre-test, during and the end of the exercise on treadmill after 10 days (post-test). Our results indicates, that there is no changes in blood glucose in EGA (30 mg thiamin/day) and CG(placebo) but showed that blood glucose reduced in EGB (300 mg thiamin/day)(P>0.05). In fact, degree of exhaustion increased in EGB that they consumed 300 mg thiamin per day, and they could to do exercise for a long time. Like the other B vitamins, thiamin is used to treat fatigue. High-dose thiamin supplementation may be helpful in preventing fatigue or accelerating recovery from exercise-induced fatigue.

VIEWS 15

Akiko Sato, Yoshimitsu Shimoyama, Tomoji Ishikawa, Nobuko Murayama. 2011. Dietary thiamin and riboflavin intake and blood thiamin and riboflavin concentrations in college swimmers undergoing intensive training. International journal of sport nutrition and exercise metabolism 21(3), 195 -204

Alireza Rahimi, Shahla Hojjat, Ali Besharati, Alireza Shokrgozar, Saba Masoumi.2012. The effect of an Aerobic exercise on IL6, CRP and TNFa concentration in women. Annals of Biological Research 3(1), 125-131

Allen  DG,  Lamb  GD,  Westerblad  H.  2008. Skeletal muscle fatigue: Cellular mechanisms. Physiological Review 88(1), 287–332. http://dx.doi.org/10.1152/physrev.00015.2007

Arici C, Tebaldi A, Quinzan GP, Maggiolo F, Ripamonti D, Suter F. 2001. Severe lactic acidosis and thiamine administration in an HIV-infected patient on HAART. International Journal of STD & AIDS 12(6), 407 – 409. http://dx.doi.org/10.1258/0956462011923228

Bautista-Hernandez VM. 2008. Effect of Thiamine Pyrophosphate on Levels of Serum Lactate, Maximum Oxygen Consumption and Heart Rate in Athletes Performing Aerobic Activity.” The Journal of international medical research 36(6), 1220-1226. http://dx.doi.org/10.1177/147323000803600608

Byun SW, Choi SH, Park HG, Kim BJ, Kim EY, Lee KH, Yang WS. 2007. A case of lactic acidosis caused by thiamine deficiency. Korean Journal of Medicine 73(4), 443-447.

Chobitko VG, Zakharova NB.1993. Prediction of the effects of energy-stabilizing drugs in diabetes mellitus. Klinicheskaia laboratornaia diagnostika 3, 15–17.

Gokhale LB. 1996. Curative treatment of primary (spasmodic) dysmenorrhea. Indian Journal of Medical Research 103, 227-231.

Holloszy JO, Coyle EF. 1984. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. Journal of Applied Physiology 56(4), 831-838.

Jacobson B, Sobonya C, Ransone J. 2001. Nutrition practices and knowledge of college varsity athletes: A follow-up. The Journal of Strength and Conditioning Research 15(1), 63-68.

Kitamori N, Itokawa Y. 1993. Pharmacokinetics of thiamine after oral administration of thiamine tetrahydrofurfuryl disulfide to humans. Journal of Nutritional Science Vitaminology 39(5), 465–472. http://dx.doi.org/10.3177/jnsv.39.465

Knippel M, Mauri L, Belluschi R. 1986. The action of thiamin on the production of lactic acid in cyclists. Medicine in Sport 39(1), 11-16.

Larrieu AJ, Yazdanfar S, Redovan E, Eftychiadis A, Kao R, Silver J, Ghosh SC. 1987. Beneficial effects of cocarboxylase in the treatment of experimental myocardial infarction in dogs. The American Surgeon 53(12), 721 – 725.

Lonsdale D. 2006. A review of the biochemistry, metabolism and clinical benefits of thiamin (e) and its derivatives. Evidence-Based Complementary and Alternative Medicine 3(1), 49-59. http://dx.doi.org/10.1093/ecam/nek009

MacRae HS, Dennis SC, Bosch AN, Noakes TD. 1992. Effects of training on lactate production and removal during progressive exercise in humans. Journal of Applied Physiology 72(5), 1649-1656.

Manore MM. 2000. Effect of physical activity on thiamine, riboflavin, and vitamin B6 requirements. American Journal of Clinical Nutrition 72(2), 598s-606s.

Marcus R, Coulston AM. 2001. Water-soluble vitamins. The vitamin B complex and ascorbic acid. In:Goodman and Gilman’s the Pharmacological Basis of Therapeutics (Hardman JG, Limbird LE, eds). New York: McGraw-Hill 3, 1753 – 1756.

McNeill AW, Mooney TJ. 1983. Relationship among carbohydrate loading elevated thiamine intake cardiovascular endurance of conditioned mice. The Journal of sports medicine and physical fitness 23(3), 257-262.

Nakamura M. 1971. The effect of thiamine tetrahydrofurfury1 disulfide on fatigue of workers in and iron works (in Japanese). Japanese Journal of Industrial Health 13, 17-36. http://dx.doi.org/10.1539/joh1959.13.17

Nelson DL, Cox MM. 2000. Lehninger Principles of Biochemistry. New York: Worth Publishers,

Nozaki S, Mizuma H, Tanaka M, Jin G, Tahara T,Mizuno K, Yamato M, Okuyama K, Eguchi A, Akimoto K, Kitayoshi T, Mochizuki-Oda N, Karaoka Y, Watanabe Y. 2009. Thiamine tetrahydrofurfury1 disulfide improves energy metabolism and physical performance during physical fatigue loading in rats. Nutrition Research 29, 867-72. http://dx.doi.org/10.1016/j.nutres.2009.10.007

Ozawa H, Homma Y, Arisawa H, Fukuuchi F, Handa S. 2001; Severe metabolic acidosis and heart failure due to thiamine deficiency. Nutrition 17(4), 351 –352. http://dx.doi.org/10.1016/S0899-9007(00)00588-8

Park DH, Gubbler CJ. 1996. Studies on the physiological functions of thiamine. V. Effects of thiamine antagonists on blood pyruvate and lactate levels and activity of lactate dehydrogenase and its isozymes in blood and tissues. Biochimica et Biophysica Acta 177(3), 537–543.

Singh A, Moses FM, Deuster PA. 1992. Vitamin and mineral status in physically active men: effects of a high-potency supplement. The American Journal of Clinical Nutrition 55(1), 1-7.

Smidt LJ, Cremin FM, Grivetti LE, Clifford AJ. 1991. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency. The Journals of Gerontology 46(1), 16-22. http://dx.doi.org/10.1093/geronj/46.1.M16

Soares MJ, Satyanarayana K, Bamji MS, Jacob CM, Ramana YV, Rao SS. 1993. The effect of exercise on the riboflavin status of adult men.British Journal of Nutrition 69(2), 541-551. http://dx.doi.org/10.1079/BJN19930054

Strumilo, Slawomir, Jan Czerniecki, Pawel Dobrzyn. 1999. Regulatory effect of thiamin pyrophosphate on pig heart pyruvate dehydrogenase complex. Biochemical and biophysical research communications 256(2), 341-345. http://dx.doi.org/10.1006/bbrc.1999.0321

Suzuki, Masashige, Yoshinori Itokawa.  1996 Effects of thiamine supplementation on exercise-induced fatigue. Metabolic brain disease 11(1), 95-106. http://dx.doi.org/10.1007/BF02080935

van der Beek EJ, van Dokkum W, Wedel M, Schrijver J, van den Berg H. 1994. Thiamin, riboflavin and vitamin B6: Impact of restricted intake on physical performance in man. The Journal of the American College of Nutrition 13(6), 629-640. http://dx.doi.org/10.1080/07315724.1994.10718459

van der Beek EJ. 1991. Vitamin supplementation and physical exercise performance. Journal of Sports Science 9, 77-90. http://dx.doi.org/10.1080/02640419108729868

Wasserman K, Beaver WL, Whipp BJ. 1986. Mechanisms and patterns of blood lactate increase during exercise in man. Medicine and Science in Sports and Exercise 18(3), 344-52. http://dx.doi.org/10.1249/00005768-198606000-00017

Webster MJ, Scheet TP, Doyle MR, Branz M. 1997. The effect of a thiamin derivative on exercise performance. European journal of applied physiology and occupational physiology 75(6), 520-524. http://dx.doi.org/10.1007/s004210050198

Webster MJ. 1998. Physiological and perfomance responses to supplementation with thiamin and pantothenic acid derivatives. European journal of applied physiology and occupational physiology 77(6), 486-491. http://dx.doi.org/10.1007/s004210050364

Woolf, Kathleen, Melinda M, Manore. 2006 B- vitamins and exercise: does exercise alter requirements? International journal of sport nutrition and exercise metabolism 16(5), 453-484.