Effect of vitamin C supplementation on lipid profile and blood sugar in normal and obese male albino rats

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Effect of vitamin C supplementation on lipid profile and blood sugar in normal and obese male albino rats

May N. Al Muammar, Islam Abdul Rahim Saad el Dien el Redh, Nawal Abdulla Al Bader, Mervat M. El-Sayed, Eman K. El. Gabry, Dina M. Trabzuni, Shaista Arzoo
Int. J. Biosci.15( 5), 506-510, November 2019.
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Vitamin C is a vital antioxidant in humans and plays significant role in various metabolic activities.Connotation has been reported between vitamin C and atherosclerosis that assessthe relationship between vitamin C and cholesterol levels.The effect of oral administration of vitamin Con serum lipids and glucose level were investigated in albino rats of wistar strain. Sixteen male albino rats were randomly divided by weight into four groups. Group 1-3 consisted of rats with normal weight (150-300gm) and 4thgroup consisted of obese rats (350-400 gm). Control group received via oral route placebo 4 ml distilled water and Test group T1 and T2 (normal weight rats) received 2.5 ml and 5 ml vitamin C respectively and test group T3 (obese rats) also received 5 ml vitamin C orally. Each tablet of vitamin C (500 mg) was dissolved in 125 ml of distilled of distilled water. The administration of vitamin C for 30 days produced significant (p≤0.05) decrease in triglycerides in test group vs control but reduction was not significant between test group and control for total cholesterol, LDL, HDL and glucose. The outcome of this study shows that supplementation of vitamin C to healthy wistar rat was found to be effective but statistically insignificant (except for triglycerides) in decreasing lipid profiles and glucose levels.


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