Effects of combined selective aerobic moderate intensity exercises and soya intake on 17β- estradiol (biomarker of breast cancer) and obesity of obese postmenopausal women

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Research Paper 01/11/2012
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Effects of combined selective aerobic moderate intensity exercises and soya intake on 17β- estradiol (biomarker of breast cancer) and obesity of obese postmenopausal women

Azam Zarneshan, Karim Salehzadeh
Int. J. Biosci.2( 11), 81-89, November 2012.
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Abstract

To investigate the independent and additive effects of selective short aerobic moderate intensity exercise and soya intake on serum 17β-estradiol and obesity in obese postmenopausal women, this quasi-experimental study conducted in 2006 on women of Uremia, Iran. So 56 obese postmenopausal women were selected and randomly divided into four groups of 14 subjects as follow: exercise-soya, exercise, soya, and control group. Pre- and post-protocol blood samples were collected and the rate of 17β-estradiol concentration was measured. Exercise training within the range of 60-70% maximum heart rate (MHR) was performed for 60 minutes, 3 sessions per week. The subjects of soya group and exercise-soya group had a 100 gram soya nut intake daily for 10 weeks. After The training course, blood samples were taken from the subjects. The collected data was analyzed using Two-way ANOVA and paired t-test. Having soya along with exercise had significant impact on reduction of 17β-estradiol means (p<0.05). Body mass index, waist to hip ratio and weight decreased significantly in exercise-soya group after 10 weeks (p<0.05). Based on the findings of this study, aerobic moderate intensity exercise along with soya intake, decrease obesity and serum 17β-estradiol in obese postmenopausal women.

VIEWS 6

Anne K, Elizabeth J, Folkerd MD. 2007. Influences on circulating estrogens in postmenopausal women: Relationship with breast cancer. journal of Steroid Biochemistry & Molecular Biology 103, 99-109.

Anne Mc T, Alderfer JR, Asmar Lk, Rajan B, Tworoger S. 2003. Adiposity and sex hormones in postmenopausal breast cancer survivors. Journal of Clinical Oncology (21), 1961-1966.

Anne Mc T. 2004. Effect of Exercise on Serum Estrogens in Postmenopausal Women. Cancer Research. (64), 2923-2928.

Anne Mc T. 2006. Physiologic studies indicate that the mode and intensity of physical activity affects the circulating endogenous hormone profile. Health & Medicine (12), 1091-1095.

Benoit J A, Melanie C ,Amelie C, Isabelle L, Jean-Pierre D, Robert RE. 2009. Effect of exercise training on cardio metabolic risk markers among sedentary, But metabolically healthy overweight or obese post-menopausal women with elevated blood pressure. Atherosclerosis (207), 530–533.

Christine D, Kimberly P, Partridge A. 2007. Implications of phytostrogen intake for breast cancer. CA Cancer J (57), 260-277.

Connolly BS, Barnett C, Bogt K N, Li T, Sone J, Boyd NF. 2002. A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer. Nutritional and Cancer (44), 127−138.

Eliana A ,Petri N, Jorge Nahas. 2006. the Effects of Soy Isoflavones in Postmenopausal Women. Clinical Review, Current Drug Therapy (1), 31-36.

Haghighian R, Farideh T, Hossein-Nezhad A, Arjmandi B, Larijani B, Kimiagar SM. 2004. The effects of soy protein on the indices of bone metabolism in postmenopausal women with osteopenia. Nutrition j (4), 62- 68.

Kalman D, Samantha F, Michele M, Diane R K and Mark JT. 2007. Effect of protein source and resistance training on body composition and sex hormones.Journal of the International Society of Sports Nutrition 4, 1-8.

Lee – j, LU W, Karl EA, James JG, Manubai N. 1996. Effect of soya consumption for one month on stroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer epidmiol biomark prev (5), 63-70.

Liao FH, Shieh MJ, Yang, SCLin SH, Chien YW. 2007. Effectiveness of a soy-based compared with a traditional low-calorie Diet on weight loss and lipid levels in over weight adults. Nutrition (23), 551-6.

Lu L- JW, Anderson KE, Grady JJ, Nagamani M. 2001. Effect of an isoflavone- free soy diet on ovarian hormones in premenopausal women. J. Clin. Endocrinol. Metab (86), 3045-52.

Maesta N, Eliana APN, Nahas-Neto J. 2007. Effects of soy protein and resistance exercise on body Composition and blood lipids in Postmenopausal women. Maturitas (56), 350–358.

Mark S, Tremblay JL, Copeland, Walter VH. 2002. Hormonal responses to endurance and resistance exercise in females aged 19-29 years. Journal of gerontology series A (57), 158 – 165.

Marianne I, Sylvia M, Martin I. 2008. Effect of soy isoflavones on 17ß-estradiol-induced proliferation of MCF-7 breast cancer cells. Toxicicology in vitro (22), 1452-1460.

Mindy SK. 2002. Hormonal effects of soy in premenopausal women and men. j. natr (132), 570-573.

Nancy I, Williams ScD. 2004. Effects of Moderate Aerobic Exercise Combined with Caloric Restriction on Circulating Estrogens and IGF-I in Premenopausal Women. Pennsylvania state University park. Report number A655034. OMB No. 0704-0188 , p. 4.

Napieralski JA, Devine C. 2008. Physical Activity and Breast Cancer. Program on Breast Cancer Environmental Risk Factors (BCERF). College of Veterinary Medicine Vet Box 31 Cornell University Ithaca, NY 14853-6401. no19,1813/ 14548.

Persky VW, Turyk ME, Wang L, Freels S. 2002. Effect of soy protein on endogenous hormones in postmenopausal women. AM J Clin Nutri 75(1), 145-53.

Rahmani Nia F. Hojati Z. 2007. Woman, Sports and   Health.   Bamdad-Ketab 964,   8131-21-X, Tehran.

Teresa  C,  Wendie  C,  Ilya  R. 2004.  Dietary phytoestrogens and health. Phytochemistry (8), 995–1016.

Tiernan Mc A, Tworoger SS, Rajan KR. 2004. Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical  trial.  Cancer  Epidemiol  Biomarkers  Prev (13), 1099 –105.

Timothy JK. 2003. Body Mass index, serum sex hormones, and breastcancerriskin postmenopausal women.  Journal of National Cancer Institute (95), 1218-1226.

Verkasalo  PK.  2001.  Circulating  levels  of  sex hormones  and  their  relation  to  risk  factors  for breast cancer. cancer cause and control (12), 47-59.