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Effects of cycling test on serum interleukin 6 and lipid profile in asthma patients

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Short Communications 01/02/2013
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Effects of cycling test on serum interleukin 6 and lipid profile in asthma patients

Eizadi M, Dooaly H, Kiani F, Khorshidi F
Int. J. Biosci.3( 2), 158-162, February 2013.
Certificate: IJB 2013 [Generate Certificate]
Key: Acute exerciseAsthmaInflammationlipid profile

Abstract

Accumulating evidence indicates that asthma is associated with systemic inflammation. It was previously reported that circulating interleukin 6 (IL-6) in asthma patients is significantly higher than normal people. This study aimed 1) to compare serum IL-6 and lipid profile between asthma patients and those without asthma, 2) to determine the effect of a single bout exercise test on mentioned variables in asthma patients. For this purpose, serum IL-6 and lipid profile such as triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (LDL) were measured in fifteen adult males with moderate asthma and fifteen healthy men matched for age and body weight. Then the measurements of these biochemical variables were repeated immediately after a stepwise cycling exercise test in asthma patient. Statistical analysis was performed with the SPSS software version 15.0. A p-value less than 0.05 were considered statistically significant. At baseline, asthma patients have higher serum IL-6 than healthy people, while there was not significant difference in lipid profile markers between two groups. Exercise test resulted in no significant change in serum IL-6 in asthma patients. Also, lipid profile markers were not affected by exercise test in studied patients. Finally, it should be acknowledged that acute exercise can not affect serum IL-6 as an inflammatory cytokine or lipid profile in moderate asthma patients.

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