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Effects of cycling test on serum interleukin 6 and lipid profile in asthma patients

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Eizadi M, Dooaly H, Kiani F, Khorshidi F

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Int. J. Biosci.3( 2), 158-162, February 2013

DOI: http://dx.doi.org/10.12692/ijb/3.2.158-162


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Accumulating evidence indicates that asthma is associated with systemic inflammation. It was previously reported that circulating interleukin 6 (IL-6) in asthma patients is significantly higher than normal people. This study aimed 1) to compare serum IL-6 and lipid profile between asthma patients and those without asthma, 2) to determine the effect of a single bout exercise test on mentioned variables in asthma patients. For this purpose, serum IL-6 and lipid profile such as triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (LDL) were measured in fifteen adult males with moderate asthma and fifteen healthy men matched for age and body weight. Then the measurements of these biochemical variables were repeated immediately after a stepwise cycling exercise test in asthma patient. Statistical analysis was performed with the SPSS software version 15.0. A p-value less than 0.05 were considered statistically significant. At baseline, asthma patients have higher serum IL-6 than healthy people, while there was not significant difference in lipid profile markers between two groups. Exercise test resulted in no significant change in serum IL-6 in asthma patients. Also, lipid profile markers were not affected by exercise test in studied patients. Finally, it should be acknowledged that acute exercise can not affect serum IL-6 as an inflammatory cytokine or lipid profile in moderate asthma patients.


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Effects of cycling test on serum interleukin 6 and lipid profile in asthma patients

Eizadi M, Shafiei M, Sedaghati S, Jenabi A. 2011. Serum Leptin and insulin resistance are not affected by an acute cycling exercise in diabetic patients. Indian Journal of Fundamental and Applied Life Sciences 1(4), 364-70.

Ford ES. 2003. Asthma, body mass index, and C reactive protein among US adults. J Asthma 40, 733-9.

Ford ES. 2005. The epidemiology of obesity and asthma. J Allergy Clin Immunol 115, 897-909.

Kishida TY, Hiromura M, Shin-Ya H, Asada H, Kuriyama M, Sugai A. 2007. IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice. Journal of Immunology 179, 8554–8561.

Kony S, Zureik M, Driss F. 2004. Association of BHR and lung function with CRP: a population based study. Thorax 59, 1-5.

Lacy P, Levi Schaffer F, Mahmudi-Azer S, Bablitz B, Hagen SC, Velazquez J. 1998. Intracellular localization of interleukin-6 in eosinophils from atopic asthmatics and effects of interferon gamma. Blood 91, 2508-2516.

Mendall MA, Strachan DP, Butland BK. 2000. C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men. Eur Heart J 21, 1584-90.

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Neveu WA, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA. 2009. IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens. Journal of Immunology 183(3), 1732-8.

Rabinovich RA, Figueras M, Ardite E, Carbó N, Troosters T, Filella X, Barberà JA, Fernandez-Checa JC,Argilés JM, Roca J. 2003. Increased tumour necrosis factor-alpha plasma levels during moderate-intensity exercise in COPD patients. Eur Respir J 21(5), 789-94.

Rogers DF. 2004. Airway mucus hypersecretion in asthma: an undervalued pathology? Curr. Opin. Pharmacol 4, 241–250.

Settin A, Zedan M, Farag M, Ezz El Regal M, Osman E. 2008. Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children. Indian J Pediatr 75(10), 1019-23.

Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. 2005. Effect of leptin on allergic airway responses in mice. Journal of Allergy and Clinical Immunology 115(1), 103-9.

Tillie I, Pugin J, Marquitte CH. 1999. Balance between proinflammatory cytokines and their inhibitors in BAL from patients with status asthmaticus. Am J Respir Crit Care Med 159, 487-94.

Yokoyama A, Kohno N, Sakai K, Kondo K, Hirasawa Y, Hiwada K. 1997. Circulating Levels of Soluble Interleukin-6 Receptor in Patients with Bronchial Asthma. Am J Respir Crit Care Med 156(5), 1688-91.

Zureik M, Benetos A, Neukirch C. 2001. Reduced pulmonary function is associated with central arterial stiffness in men. Am J Respir Crit Care Med 164, 2181-5.