Effects of exercise on glycaemic control and insulin action in type II diabetes mellitus

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Research Paper 01/12/2011
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Effects of exercise on glycaemic control and insulin action in type II diabetes mellitus

Eizadi Mojtaba, Khorshidi Davood, Dooaly Hussein, Samarikhalaj Hamidreza
Int. J. Biosci.1( 6), 147-154, December 2011.
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Exercise training is widely used for improving glycemic control and insulin action in diabetic patients. This study aimed to investigation effect a single bout and long exercise training program on glycemic indicators in type 2 diabetic patients. A 32 adult males with type 2 diabetic placed randomly in two control and experimental groups. For measuring of glucose and insulin concentration, a venous blood sample was collected after an overnight fast, immediately a single bout exercise and after three months aerobic exercise program in experimental group or control group (detraining in all stages). From insulin and glucose data used for calculation insulin sensitivity, insulin resistance and ß-cell function. Anthropometric indices in both groups were measured before and after prolonged exercise. Statistical analysis was performed using independent-paired T test (p <0.05). There were no significant changes in insulin sensitivity and insulin resistance after single bout exercise compared to baseline levels, but long-time exercise program improved significantly these variables(p <0.05). Glucose concentration decreased significantly and b-cell function increased significantly in response to either single bout or long-time exercise (p <0.05). None of the variables in the control group changed (p ≥ 0.05). Our findings indicate that the reduction in blood glucose concentrations after exercise in patients with diabetes is due to improvement of insulin action and beta cell function.


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