Effects of exercise training intervention without weight loss on glucose and insulin resistance in obese women

Paper Details

Research Paper 01/09/2013
Views (301) Download (4)
current_issue_feature_image
publication_file

Effects of exercise training intervention without weight loss on glucose and insulin resistance in obese women

Zahedmanesh Forouzan, Yousefi Soheila, Pishkar Leila, Zahedmanesh Farnaz
Int. J. Biosci.3( 9), 324-328, September 2013.
Certificate: IJB 2013 [Generate Certificate]

Abstract

Growing bodies of literature have indicated an association of obesity with insulin resistance. In this study, Thirty two sedentary adult obese women (age, 38 ± 4.3 yr, BMI, 32.42 ± 3.3 kg/m2) were divided into exercise (aerobic training, 6 weeks/3 times per week) or control (without exercise) group. Fasting venous blood samples were obtained before and after exercise program for measuring insulin and glucose and insulin resistance. Student’s paired ‘t’ test was applied to compare the pre and post training values. Aerobic training decreased fasting glucose concentration in exercise group but not in the control group. Insulin resistance tended to (borderline) be decrease by aerobic training in exercise group, but did not reach statistical significance. Insulin concentration did not change with aerobic training program. Based on these data, we can say the changes in glucose concentration in response to aerobic training does not affect by insulin action only, and Can be attributed to the changes in other hormonal changes.

VIEWS 2

American College of Sports Medicine. 1998. American College of Sports Medicine Position Stand: exercise and physical activity for older adults. Medicine Science and Sports Exercise 30, 992–1008. http://dx.doi.org/10.1097/00005768-199806000-00033

Biswajit M, Chowdhury M. H, Laboni M, Paramita P, Miltu KG. 2013. Obesity and Insulin Resistance: An Abridged Molecular correlation. Lipid Insights 6, 1-11.

Bonner-Weir S. 1994. Regulation of pancreatic beta-cell mass in vivo. Recent progress in hormone research 49, 91–104.

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. 2003. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102–110. http://dx.doi.org/10.2337/diabetes.52.1.102

Defronzo RA, Hendler R, Simonson D. 1982. Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes 31, 795–801. http://dx.doi.org/10.2337/diab.31.9.795

Duncan M, Singh B, Wise P. 1995. A simple measure of insulin resistance. Lancet 346, 120–1. http://dx.doi.org/10.1016/S0140-6736(95)92143-5

Gomes MR, Rogero MM, Tirapegui J. 2005. Considerações sobre cromo, insulina e exercício físico. Revista Brasileira de Medicina do Esporte 11, 262-6.

Kahn SE. 2000. The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus. American Journal of Medicine 108, Suppl 6, 2-8. http://dx.doi.org/10.1016/S0002-9343(00)00336-3

Kim J, Wei Y, James R. 2008. Role of Mitochondrial Dysfunction in Insulin Resistance. American Heart Association 102, 401-414.

Kloppel G, Clemens A. 1997. Insulin-Dependent Diabetes Mellitus: Islet Changes in Relation to Etiology and Pathogenesis. Endocrine Pathology 8, 273–282. http://dx.doi.org/10.1007/BF02739929

Lazar MA. 2005. How obesity causes diabetes: not a tall tale. Science 307, 373–375. http://dx.doi.org/10.1126/science.1104342

Ropelle ER, Pauli JR, Carvalheira JBC. 2005. Efeitos moleculares do exercício físico sobre as vias de sinalização insulínica. revista de educação física 11, 49-55.

Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C. 2004. Physical Activity/Exercise and Type 2 Diabetes. Diabetes Care 27(10), 2518-39. http://dx.doi.org/10.2337/diacare.27.10.2518

Teran-Garcia M, Rankinen T, Koza RA, Rao DC, Bouchard C. 2005. Endurance training-induced changes in insulin sensitivity and gene expression. American Journal of Physiology – Endocrinology and Metabolism 288, 1168-78. http://dx.doi.org/10.1152/ajpendo.00467.2004

Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M. 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine 344, 1343–1350. http://dx.doi.org/10.1056/NEJM200105033441801