Effects of hexavalent chromium on structure of liver, intestine and ovary of Zebra fish

Paper Details

Research Paper 10/09/2023
Views (351) Download (25)
current_issue_feature_image
publication_file

Effects of hexavalent chromium on structure of liver, intestine and ovary of Zebra fish

Dang Dang Khoa, Nguyen Thi Phuong Thao, Le Thanh Long
Int. J. Biosci.23( 3), 164-169, September 2023.
Certificate: IJB 2023 [Generate Certificate]

Abstract

The study aimed to evaluate the effects of chromium (vi) on zebrafish’s liver, intestines and ovaries on the following days: day 5, day 10, day 20, day 30, respectively. The results showed that the longer the zebrafish exposed to chromium (vi) in water, the more chromium (vi) accumulated in the whole body. Analytical results showed that chromium (VI) accumulation concentration increased with the highest exposure time at day 30 (23.9±1.0mg/kg), this content was 4 times higher than day 5 (6.1±0.4).mg/kg), 3 times higher than day 10 (9.3±0.6mg/kg), 1.5 times higher than day 20 (17±0.8mg/kg). For the control batch, the ratio was 0%, indicating that the amount of chromium (VI) did not accumulate in the fish’s body. Based on the results, the damaged intestinal tissue structure increased over time while the adipose tissue decreased and the villi increased densely over time. The structure of zebrafish ovarian tissue changed and the proportion of lipid particles decreased when the fish were exposed to chromium (VI) concentrations for a long period of time. Beside that, the liver tissue structure appeared inflammatory foci and the inflammation became more severe with exposure time.

VIEWS 44

Bhatnagar C, Bhatnagar M, Regar BC. 2007. Fluoride-induced histopathological changes in gill, kidney, and intestine of fresh water. Research report Fluoride 40(1), 55-61.

Cao J, Wang G, Wang T, Chen J, Wenjing G, Wu P, He X, Xie L. 2019. Copper caused reproductive endocrine disruption in zebrafish (Danio rerio). Aquat Toxicol 211, 124-136.

Dang KD, Ho CNQ, Van HD, Dinh ST, Nguyen QTT, Nguyen TTT, Kien XTN, Dao TV, Nong HV, Nguyen MT. 2023. Hexavalent Chromium Inhibited Zebrafish Embryo Development by Altering Apoptosis- and Antioxidant-Related Genes. Curr. Issues Mol. Biol 45, 6916-6926.

Hill AJ, Teraoka H, Heideman W, Peterson RE. Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity. 2005. Toxicological Sciences 86(1), 6-19.

Huyen NTT, Huy TA, Giang NTT, Dung TTP. 2013. A research on the possibility of cadmium (Cd) accumulation in Zebrafish-Danio rerio (Hamilton, 1822). HCMUE J. Sci 51, 90-99.

Jin Y, Liu Z, Liu F, Ye Y, Peng T, Fu Z. 2015. Embryonic exposure to cadmium (II) and chromium (VI) induce behavioral alterations, oxidative stress and immunotoxicity in zebrafish (Danio rerio). Neurotoxicol Teratol 48, 9-17.

Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. 1995. Stages of embryonic development of the zebrafish. Dev Dyn. 203(3), 253-310.

Lu N, Sun S, Song W, Jia R. 2017. Behavioural toxicity in zebrafish (Danio rerio) exposed to waterborne zinc and chromium (VI). Chemistry and Ecology 33(8), 725-738

Renieri EA, Alegakis AK, Kiriakakis M, Vinceti M, Ozcagli E, Wilks MF. 2013. Cd, Pb and Hg Biomonitoring in Fish of the Mediterranean Region and Risk Estimations on Fish Consumption. Toxics 2(3), 417-442.

Renieri EA, Safenkova IV, Alegakis AΚ, Slutskaya ES, Kokaraki V, Kentouri M. 2019. Cadmium, lead and mercury in muscle tissue of gilthead seabream and seabass: Risk evaluation for consumers. Food and Chemical Toxicology 124, 439-449.

Rosli MNR, Samat SB, Yasir MS, Yusof MFM. 2018. Analysis of Heavy Metal Accumulation in Fish at Terengganu Coastal Area, Malaysia. Sains Malaysiana 47(6), 1277-1283.

Tulasi SJ, Reddy PJ, Rao JVR. 1992. Accumulation of lead and effects on total lipids and lipid derivatives in the freshwater fish Anabus testudineus (Bloch). Ecotoxicol. Environ. Safety 23, 33-38.

Xu Y, Wang L, Zhu J, Jiang P, Zhang Z, Li L, Wu Q. 2021. Chromium induced neurotoxicity by altering metabolism in zebrafish larvae. Ecotoxicology and Environmental Safety 228, 112983.

Yan T, Xu Y, Zhu Y, Jiang P, Zhang Z, Li L, & Wu Q. 2023. Chromium exposure altered metabolome and microbiome-associated with neurotoxicity in zebrafish. Journal of Applied Toxicology 43(7), 1026-1038.

Younis ESM, Abdel-Warith AWAM, Al-Asgah NA, Ebaid H, Mubarak M. 2013. Histological changes in the liver and intestine of Nile tilapia, Oreochromis niloticus, exposed to sublethal concentrations of cadmium. Pakistan Journal of Zoology 45(3), 833-841.