Int. J. Biosci.2(4), 90-95, April 2012
This study was conducted to investigate the effect of alcohol consumption on the liver of apparently healthy human subjects resident in Vom and its environs. Blood samples were collected from 120 subjects and serum level of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline Phosphatase (ALP) were estimated by IFCC kinetic method using available commercial Reagent Kit (DIALAB Scientific Laboratories, Austria) and colorimetric end point method. All the enzymes, ALT, AST and ALP assayed were significantly higher (p<0.05) in alcoholics than non-alcoholics. The frequency distribution shows that greater percentage of alcoholics have above normal levels of all liver enzymes assayed while greater percentage of non-alcoholics have normal levels of the liver enzymes, the age group (41- 50 years) has greatest percentage of high levels of the enzymes and greater percentage of men have high levels of the enzymes than women. Therefore, the study suggests that excessive consumption of alcohol predisposes humans to the risk of developing alcoholic liver disease and men are at greater risk than women in Vom and its environs.
Achliya GS, Kotgale SG, Wadodkar AK, Dorle AK. 2003. Hepatoprotective activity of Panchgavya grithaz in carbon-tetrachloride induced hepatotoxicity in rats. Indian Journal of Pharmacology 35, 311 – 315.
Aliyu R, Adebayo AH, Gatsing D, Garba IH. 2007. The effects of ethanolic leaf extract of Commiphora africana (Burseraceae)on lipid profile in rats. International Journal of Pharmacology 2, 618 – 622.
Baraona E, Abittan CS, Dohmen K, Moretti M, Pozzato G, Chayes ZW. 2001. Gender differences in pharmacokinetics of alcohol. Alcohol Clinical and Experimental Research 25, 502 – 507.
Benjamin MN. 1978. Outline of Veterinary Clinical Pathology. IOWA, USA: University Press, 229 – 232.
Burtis CA, Ashwood ER. 2001. Enzymes. In: Tietz Fundamentals of Clinical Chemistry, 5th ed. New York, USA: W.B. Saunders Company, 352 – 369.
Corrao G, Ferrari P, Zambon A, Torchio P. 1997. Are the recent trends in liver cirrhosis mortality affected by the changes in alcohol consumption? Analysis of latency period in European countries. Journal of the Study of Alcohol 58, 486 – 494.
Dianzani MU, Muzia G, Biocca ME, Canuto RA. 1991. Lipid peroxidation in fatty liver induced by caffeine in rats. International Journal of Tissue Reaction 13, 79 – 85.
Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB. 2000. Diagnosis and monitoring of hepatic injury I. Recommendations for use of laboratory tests in screening, diagnosis and monitoring. Clinical Chemistry 46, 2050 – 2068.
Ellis G, Goldberg DM, Spooner RJ. 1978. Serum enzyme tests in diseases of the liver and biliary tree. American Journal of Clinical Pathology 70, 248 – 258.
Hezode C, Lonjon I, Roudot-Thoraval F. 2003. Impact of moderate alcohol consumption on histological activity and fibrosis in patients with chronic hepatitis C, and specific influence of steatosis: A prospective study. Alimentary Pharmacology and Therapeutics 17(8), 1031 – 1037.
Mann RE, Smart RG, Goroni R. 2003. The epidemiology of alcoholic liver disease. Alcohol Research and Health 27(3), 209 – 219.
Mayne PD. 1998. Clinical chemistry Diagnosis and Treatment, 6th ed. London, UK: Arnold International, 199 – 204.
Moss DW, Henderson AR. 1999. Clinical enzymology. In: Burtis CA, Ashwood ER, eds. Tietz Textbook of Clinical Chemistry, 3rd ed. Philadelphia, USA: WB Saunders, 617 – 721.
Nalpas B, Vassault A, charpin S, Lacour B, Berthelot P. 1986. Serum mitochondrial aspartate aminotransferase as a marker of chronic alcoholism: diagnostic value and interpretation in a liver unit. Hepatology 6, 608 – 614.
Nduka N. 1997. Clinical Biochemistry for Students of Chemical Pathology, 1st ed. Lagos, Nigeria: Longman Nigeria Plc, 122 – 123.
Nunez M, Lana R, Mendoza JL, Martin- Carbonero L, Soriano V. 2001. Risk factors for severe hepatic injury after introduction of highly active anti-retroviral therapy. Journal of Acquired Immune Deficiency Syndrome 27, 426 – 431.
O’shea RS, Dasarathy S, Mc Cullough AJ. 2010. Alcoholic liver disease. Hepatology 51, 307 – 328.
Rajesh SV, Rajkapoor B, Senthilkumar R, Raju K. 2009. Effect of Clausena dentata (wild) M.Roem. against paracetamol-induced hepatotoxicity in rats. Pakistan Journal of Pharmaceutical Sciences 22(1), 90 – 93.
Reitman S, Frankel S. 1957. A method of assaying liver enzymes in human serum. American Journal of Clinical Pathology 28, 56 – 58.
Szabo G, Zakhari S. 2011. Mechanisms of alcohol-mediated Hepatotoxicity in Human immuno-deficiency virus-infected patients. World Journal of Gastroenterology 17(20), 2500 – 2506.
Vasudevan DM, Sreekumari S. 2007. Isoenzymes and Clinical Enzymology. In: Textbook of Biochemistry for medical students, 5th ed. New Delhi,India: Jaypee Brothers Medical Publishers, 52 – 58.
Yoon YH, Yi HY. 2006. Surveillance report #75: Liver cirrhosis Mortality in the United States, 1970 – 2003. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism.