Enzymes as markers of liver damage in apparently healthy alcohol drinkers resident in Vom community

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Research Paper 01/04/2012
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Enzymes as markers of liver damage in apparently healthy alcohol drinkers resident in Vom community

Patricia Oluchukwu Okonkwo, Blessing Edagha, Raphael John Ogbe
Int. J. Biosci.2( 4), 90-95, April 2012.
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This study was conducted to investigate the effect of alcohol consumption on the liver of apparently healthy human subjects resident in Vom and its environs. Blood samples were collected from 120 subjects and serum level of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline Phosphatase (ALP) were estimated by IFCC kinetic method using available commercial Reagent Kit (DIALAB Scientific Laboratories, Austria) and colorimetric end point method. All the enzymes, ALT, AST and ALP assayed were significantly higher (p<0.05) in alcoholics than non-alcoholics. The frequency distribution shows that greater percentage of alcoholics have above normal levels of all liver enzymes assayed while greater percentage of non-alcoholics have normal levels of the liver enzymes, the age group (41- 50 years) has greatest percentage of high levels of the enzymes and greater percentage of men have high levels of the enzymes than women. Therefore, the study suggests that excessive consumption of alcohol predisposes humans to the risk of developing alcoholic liver disease and men are at greater risk than women in Vom and its environs.


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