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Evaluating the effects of Levonorgestrel on female gonads of Rattus albicans

Research Paper | October 1, 2021

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Palki Hazarika, Kamal Choudhury

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Int. J. Biosci.19( 4), 108-115, October 2021

DOI: http://dx.doi.org/10.12692/ijb/19.4.108-115


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Though the repeated or long term use of progesterone only birth control measures are found to be disruptors of reproductive cycle, it is often reported that the effects of an exogenous progesterone analog on the histology of reproductive organs cannot be predicted easily, which is utmost important for the users. Therefore, the present work is designed to enumerate whether a commonly used synthetic progestogen, Levonorgestrel (LNG) has disruptive effects on the ovarian histology at a dose of 1.5mg/kg b.w/day for 03 consecutive days at 24 h time interval in cyclic ovary-intact female rats.Present investigation reveals that administration of LNG reduces ovary sizes, causes detachment of the cumulus oophorous cells from the oocyte, changes the shape of the oocyte, increased follicular atresia along with increase in number of secondary follicles and decrease in numbers of primordial and grafiaan follicles. Number of corpus luteum was also decreases. From these results, it can be concluded that prolonged or repeated use of LNG may disrupt the ovarian activity by affecting folliculogenesis, rate of ovulation thereby the rate of fertility in females. Information from this study might help researchers to develop certain contraceptives from natural resources with little side effects rather than synthetic contraceptives.


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Evaluating the effects of Levonorgestrel on female gonads of Rattus albicans

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