Evaluation of antinociceptive effect of Terminalia arjuna bark ethanol extract

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Research Paper 01/08/2011
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Evaluation of antinociceptive effect of Terminalia arjuna bark ethanol extract

K Ushna Sameen Islam, Zafreen Afsana, M Alam Morshed, M Azim Uddin, JMA Hannan, Tanzia Akhter Khan, Mirza Golam Sarwar
Int. J. Biomol. & Biomed.1( 2), 7-16, August 2011.
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Abstract

Stem bark of the plant Terminalia arjuna were extracted in 50% ethanol to evaluate for centrally acting analgesic potential using formalin, hot plate and peripheral pharmacological actions using acetic acid induced writhing test in mice. The extract of the plant were found to have significant (p<0.01) analgesic activity at the oral dose of 250 & 500 mg/kg body weight, in the tested models. In hot plate test, at both dose levels (250mg/kg and 500mg/kg), T. arjuna extract showed significant (p<0.001) increased latency period than the control group. In acetic acid induced writhing test and formalin test T. arjuna also showed reduced number of writhes than the control group at two dose levels which are significant (p<0.05) compared to control. The results obtained support the use of stem bark of T.arjuna in painful conditions acting both centrally and peripherally.

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