Evaluation of haematological parameters in dengue infection

Paper Details

Research Paper 01/07/2019
Views (303) Download (21)

Evaluation of haematological parameters in dengue infection

Anees Muhammad, Zia Ur Rahman, Malik Zeb Khan, Mehreen Hameed, Hina Hayat
Int. J. Biosci.15( 1), 548-553, July 2019.
Certificate: IJB 2019 [Generate Certificate]


Dengue cause high mortality and morbidity in developing countries due poor preventable management and un-hygienic condition. Early identification and diagnosis of dengue infection is important for provision of particular care and to reduce the fatality outcomes. The aim of this study was to determine the haematological parameter in dengue viral infected patients in Peshawar, Khyber Pakhtunkhwa province of Pakistan. Demographic, clinical, serological and hematological information from n=2189 patients were obtained in duration of January 2017-January 2018 in district Peshawar. Serological test were performed on Immunochromatography technique for detection of non-structural antibodies against dengue virus. All non-structural antibodies (positive) cases were confirmed by standard Enzyme Linked Immunosorbent Assay. Automated sysmax X-2100 were used for Haematological parameters (complete blood count). Statistical package for social sciences version 21 were used for data analysis. Out total 2189 patients, 59.06% were male and 40.94% were female. Burden of dengue infection was 25.94% (n=568) as examined positive. Majority dengue infected patients were diagnosed in age of 21-30 years with high male percentage (59.06%). Frequently affected hematological parameter was lymphocytes and mean cell hemoglobin concentration in numerous dengue viral infected patients while mean cell hemoglobin was observed decreased in all patients. Platelets were decreased in age group of ≥70 years. This study shows that the prevalence of dengue was high with significance impact on hematological parameters. There is need to initiate Public-awareness campaign and also educate them regarding the spread of dengue fever and vector control. These measures, eventually, will lead to implement community-friendly and sustainable disease management strategies in the country.


Ahmed S, Ali N, Ashraf S, Ilyas M, Tariq W, Chotani RA. 2008. Dengue fever outbreak: a clinical management experience. J Coll Physicians Surg Pak 18(1), 8-12.

Butthep P, Chunhakan S, Yoksan S, Tangnararatchakit K, Chuansumrit A. 2012. Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever. The Pediatric infectious disease journal 31(12), e232-e238.

Ekanayake D, Perera H, Ellepola A, Athauda S. 2013. Analysis of blood parameters & RT-PCR results in dengue suspected patients from Sri Lanka. International Journal of Research 3(1), 2307-2083.

Gajera VV, Sahu S, Dhar R. 2016. Study of haematological profile of Dengue Fever and its clinical implication. Annals of Applied Bio-Sciences 3(3), 2455-0396.

Gitika MG, Gill GS. 2018. Evaluation of Hematological and Biochemical Profile of Early Dengue Patients. Headache 2, 57-65.

Jahan F. 2011. Dengue fever (DF) in Pakistan. Asia pacific family medicine 10(1), 1.

Jampangern W, Vongthoung K, Jittmittraphap A, Worapongpaiboon S, Limkittikul K, Chuansumrit A, . . . Chongsa-Nguan M. 2007. Characterization of atypical lymphocytes and immunophenotypes of lymphocytes in patients with dengue virus infection. Asian Pacific Journal of Allergy and Immunology 25(1), 27.

Joshi AA, Gayathri B, Muneer F. 2018. Dynamics of differential count in dengue. International Journal of Advances in Medicine 5(1), 145.

Khan E, Kisat M, Khan N, Nasir A, Ayub S, Hasan R. 2010. Demographic and clinical features of dengue fever in Pakistan from 2003–2007: a retrospective cross-sectional study. PloS one 5(9), e12505.

Lounibos LP, Kramer LD. 2016. Invasiveness of Aedes aegypti and Aedes albopictus and vectorial capacity for chikungunya virus. The Journal of infectious diseases 214(suppl_5), S453-S458.

Malathesha M, Ashwini H. 2014. Hematological manifestations in dengue fever—An observational study. J. Evol. Med. Dental Sci 3, 2245-2250.

Pai Jakribettu R, Boloor R, Thaliath A, Yesudasan George S, George T, Ponadka Rai M, . . . Baliga MS. 2015. Correlation of clinicohaematological parameters in paediatric dengue: a retrospective study. Journal of tropical medicine 2015.

Patel K, Patel D, Das V. 2016. Hematological Parameters and Its Utility in Dengue fever: A prospective study. International Journal of Science and Research (IJSR) 5(4).

Paul RE, Patel AY, Mirza S, Fisher-Hoch SP, Luby SP. 1998. Expansion of epidemic dengue viral infections to Pakistan. International journal of infectious diseases 2(4), 197-201.

Salam N. 2018. Analysis of the Effects of Rainfall on Dengue Incidence in the City of Delhi, India. International Journal of Medical Research & Health Sciences 7(12), 149-155.

Tsai JJ, Chang JS, Chang K, Chen PC, Liu LT, Ho TC. Perng GC. 2017. Transient monocytosis subjugates low platelet count in adult dengue patients. Biomedicine Hub 2(1), 8-8.

Vasanthapuram R, Hameed SKS, Desai A, Mani RS, Reddy V, Velayudhan A, . . . Borthakur A. 2019. Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a four year AES surveillance study of Japanese encephalitis in selected states of India. International journal of infectious diseases 5, 45-51.