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Evaluation of hepato-protective activity of B. lycium methenolic crude extracts collected from Distric Sherani, Balochistan

Sami Ullah Sherani, Javied Iqbal, Amanullah Khan, Muhammad Ali Khan, Nadeem Rashid, Mohammad Rahim Niazi, Zia Ud Din, Mohamad Kamran Taj

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J. Bio. Env. Sci.14(6), 77-83, June 2019

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Abstract

Berberis lycium, which is commonly called as Indian barberry (English) and Kashmal or Ishkeen in Urdu, is a spiky plant which is the member of the genus Berberis of family Berberidaceae. B. lycium also includes anti-hepatotoxicity effect, when was mixed with G. aparine and P. integerrima and was tested in rats that were treated with carbon tetra chloride; the results revealed that the combination of these three medicinal plants encompasses anti hepatotoxicity effects. B. lycium (root) sample was collected from the hill of village of Ahmadedergah near to Tahkhta Suleiman District Sherani Balochistan, Pakistan. The collected samples were identified by Pharmacognosy, Department faculty of Pharmacy University of Baluchistan, Quetta. Adult healthy rabbits (male) having weights approximately 950g-1300g, were kept in animals house at CASVAB, UoB. Sample serum, within 3 hours after collection , was analyzed  for certain biochemical parameters (Alkaline phosphatase (ALP), Alanine aminotransferase (ALT), Gamma glutamyl transpeptidase (γ-GT), Aspartate aminotransferase (AST), and total Proteins like Bilirubin,  Albumin and Globulin) through automatic analyzer (Merck) at 37oC through standard reagent kits. The obtained values for LFT in the current portion of controlled group were, 0.76± 0.060, 0.032±0.008(mg/dL), 4.2±0.802, 93.8±1.500, 2.28±0.107 and 273±2.818(U/L) for TB, DB, ALT, AKP, GGT, SGOT and SGPT (AST) levels. Whereas, the group treated with CCl4 these parameters were, 0.86±0.075, 0.064+0.006(mg/dL), 4.6±0.680, 2.44±0.150, 90.4±3.467 and 218.4±1.439(U/L) level. While, the group treated with CCl4 and B. lycium 500mg, the above parameters were calculated as 0.92±0.086, 0.442±0.228(mg/dL), 4.4±0.601, 93.2±1.244, 2.62±0.097 and 221.6±1.540(U/L), respectively.

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Evaluation of hepato-protective activity of B. lycium methenolic crude extracts collected from Distric Sherani, Balochistan

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