Evaluation of Pistacia integrrima; an important plant

Paper Details

Research Paper 01/11/2017
Views (368) Download (11)

Evaluation of Pistacia integrrima; an important plant

Muhammad Shuaib, Kashif Ali, Umar Zeb, Firasat Hussain, Muhammad Aurang Zeb, Saddam Hussain, Fida Hussain
Int. J. Biosci.11( 5), 412-420, November 2017.
Certificate: IJB 2017 [Generate Certificate]


Pistacia integrrima is a typical therapeutic plant belongs to family Anacardiaceae and local to Japan, China and found in the Northern regions of Pakistan commonly called KakrraSingi (Urdu) and Shanai (Pushto). It is used ethnomedicinally for a number of diseases include fever, cough, asthma, vomiting, Ascaris, Anorexia, Allergy, viral infections, diarrhea, snake and scorpion biting sting. The different parts of the plant roots, leaves, stems, barks, Galls and fruits contains various bioactive compounds like amino acid, alkaloids, sterols, flavonoids, tannins, saponins, aromadendrene, Pistacinin, Pistacin, Dihydromalvic acid, Pistacienoic acid, sitosterol, resin, essential oils, caprylic acid, camphene, cineol, sterals, dihydroqueretin and triterpenoids. Antimicrobial activity of chloroform and ethanol leaves extract from Pistacia integrrima reported in many research papers. The leave extract exhibited the fungi growth including Aspergillus flavus, Dreschlera turcica and Fusarium verticillioides. The plant is known to have many biological activities including antibacterial, antifungal, analgesic, antioxidant, phytotoxic, cytotoxicity and antiasthmatic. The current review will cover biological activities, phytochemical evaluation, ethnomedicinal uses, ethnobotanical uses and aim to serve as a base for additional investigation and exploitation. The current review shows a gap needed further investigations and isolations of new compound, and its biological activities.


Abbasi AM, Khan MA, Ahmad M, Zafar M, Khan H, Muhammad N, Sultana S. 2009. Medicinal plants used for the treatment of jaundice and hepatitis based on socio-economic documentation. African J. Biotech 8, 1643-1650.

Abbasi AM, Khan MA, Ahmad M, Zafar M. 2010. Herbal medicines used to cure various ailments by inhabitants of Abbottabad district, North West Frontier, Pakistan. Ind. J. Trad. Know 9: 175-183.

Adusumalli Y, Ranjit PM, Harish MS. 2013. Antiasthmatic activity of aqueous extract of Pistacia integerrima Galls. International Journal of Pharmacy and Pharmaceutical Sciences 2, 0975-1491.

Aggarwal BB, Ichikawa H, Garodia P, Weerasinghe P, Sethi G, Bhatt ID, Pandey MK, Shishodia S, Nair MG. 2006. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin. Ther. Targets 10, 87-118.

Ahmad R, Pieters L, Rahman NU, Riaz M. 2013. Antimicrobial and antioxidant activity of crude extracts of two medicinal plants Pistacia integerrima and Debregeasia salicifolia. Inter. J. Pharmaceut. Sci 18(1), 13-17.

Ahmad S, Ali M, Ansari SH. 2010. Phenolic constituents from galls of Pistacia integerrima Stewart. Ind. J. Chem 50B, 115-118.

Ali K, Shuaib M, Hussain Z, Sajjad W, Ali F, Fazil M. 2016. Ethnobotanical assessment of the medicinal flora of Khyber agency, Pakistan. Pak. J. Weed Sci. Res 22(4), 607-616.

Anonymous. 2011. The Database on Medicinal Plants used in Ayurveda, Published by Central Council for Research in Ayurveda and Siddha, Govt. of India, New Delhi 169.

Anzana P, Jesmin A, Md. Mehedi H, Nirupam B. 2013. Study on the comparative antibacterial activity of Polyalthia longifolia (Debdaru) leaf extracts to some selective pathogenicbacterial strains 3(5), 17-24.

Barkatullah Ibrar M, Muhammad N. 2011. Evaluation of Zanthoxylum armatum DC for in-vitro and in-vivo pharmacological screening. Afr. J. Pharma. Pharmacol 5(14), 1718-1723.

Bibi Y, Nisa S, Chaudhary MF, Zia M. Antibacterial activity of some selected medicinal plants of Pakistan. BMC Comp. Alt. Med 11, 52.

Bibi Y, Sobia N, Chaudhary FM, Zia M. 2011. Antibacterial activity of some selected medicinal plants of Pakistan. BMC Complementary and Alternative Medicine 11:52.

Bibi Y, Zia M, Qayyum A. 2012. An overview of Pistacia integerrima a medicinal plants species: Ethnobotany, biological activities and Phytochemistry 2012.

CDC. 2005.Tuberculosis transmission in a homeless shelter population- New York, 2000–2003. MMWR 54, 149–52.

Chopra RN, Nayar SL, Chopra IC. 1986. Glossary of Indian medicinal plants (Including the Supplement). Council of scientific and industrial research, New Delhi.1986.

Dastagir G, Hussain F. 2013. Phytotoxic and insecticidal activity of plants of family Zygophyllaceae and Euphorbiaceae. Sarhad J. Agric 29(1).

Dellavalle PD, Cabrera A, Alem D, Larrañaga P, Ferreira F, Rizza MD. 2011. Antifungal activity of medicinal plant extracts against phytopathogenic fungus Alternaria sp. Chilean Journal of Agricultural Research  71(2), 231-239.

Doughari JH. 2006. Antimicrobial Activity of Tamarindus indica Linn. Tropical Journal of Pharmaceutical Research 5 (2): 597-603.

Elisabetsky E. 1991. Sociopolitical, economical and ethical issues in medicinal plant research. J Ethnopharmacol 32, 235–239.

Fazli K, Zafar I, Zakiullah, Ayub K, Fazli N, Naveed M, Ali KJ, Shafiq KM. 2012. Metal analysis, phytotoxic, insecticidal and cytotoxic activities of selected medicinal plants of Khyber Pakhtunkhwa. Pak. J. Pharm. Sci. 25, 51-58.

Ghias Uddin, Abdur R, Taj UR, Qaisar M. 2011. Phytochemical Screening of Pistacia chinensis var. integerrima. Middle-East Journal of Scientific Research 7 (5), 707-711.

Hamayun M, Khan SA, Sohn EY, Lee IJ. 2006. Folk medicinal knowledge and conservation status of some economically valued medicinal plants of District Swat, Pakistan. Journal of Ecology and application 11(2).

Hameed I,  Hussain F, Zaman S, Bacha  N, Khan AA. 2013. Cytotoxicity and phytotoxicity of some selected medicinal plants of family Solanaceae. Pak. J. Bot 45(5), 1749-1754.

Hossein Hosseinzadeha, Effat B, Mohammad MS. 2011. Antinociceptive and Anti-inflammatory Effects of Pistacia vera Leaf Extract in Mice. Iranian Journal of Pharmaceutical Research 10(4), 821-828.

Hussain F, Shah SM, Sher H. 2007. Traditional resource evaluation of some plants of Mastuj, District Chitral, Pakistan. Pak. J. Bot. 39, 339-354.

Islam M, Ahmad H, Rashid A, Razzaq A, Akhtar N, Khan I. 2006. Weeds and medicinal plants of Shawar Valley, district Swat. Pak J. Weed Sci. Res 12: 83-88.

Izhar A, Ikram I, Samar S, Khan I. 2013. In vitro antioxidant activities of four medicinal plants on the basis of DPPH free radical scavenging. Pak. J. Pharm. Sci. 26(5), 949-952.

Jan S, Khan MA, SirajUd-din, Murad W, Hussain M, Ghani A. 2006. Herbal remedies used for gastrointestinal disorders in Kaghanvalley, NWFP, Pakistan. Pak. J. Weed Sci. Res 14, 169-200.

Kaur B, Singh S.  2015. A review on gall karkatshringi.  J. Medi. P Res  9:636-640.

Khan MA, Khan MA, Hussain M. 2012. Medicinal Plants Used in Folk Recipes by the Inhabitants of Himalayan Region Poonch Valley Azad Kashmir (Pakistan). J. Basic Appl. Sci 8, 35-45.

Mulligen ME, Kauffman CA, Yu VL.  1993. American Journal of Medicine 94, 313-28.

Munir M, Khan MA, Ahmed M, Bano A, Ahmed SN, Tariq K, Tabassum S, Mukhtar T, Ambreen M, Bashir S. 2006. Foliar epidermal anatomy of some ethnobotanically important species of wild edible fruits of northern Pakistan. J. Med. Plants Res 5, 5873- 5880.

Orwa C, Mutua A, Kindt R, Jamnadass R, Simons A. 2009. Agroforest tree database: a tree reference and selection guide version 4.0.

Pant S, Samant SS. 2010. Ethnobotanical observations in the Mornaulareserve forest of Kumoun, west Himalaya, India. Ethnobotanical Leaflets 14, 193.

Piddock KJV, Wise R.  1991. Journal of Antimicrobial chemotherapy  23, 475-83.

Rahman S, Ismail M, Muhammad N, Ali F, Chisthi AK, Imran M. 2011.Evaluation of the stem bark of Pistacia integerrima Stewart ex Brandis for its antimicrobial and phytotoxic activities. Afr. J. Pharmac. Pharmacol 5, 1170-1174.

Ramachandra YL, Ravi SBE, Sujan GPS, Sundar RS. 2010. In-vitro antimicrobial activity of Pistacia integerrima leaf gall extracts.  Pharmacophore 1(2), 149-154.

Rauf A, Uddin G, Raza M. 2016.Reversal of multidrug resistance in mouse lymphoma cells by extracts and flavonoids from Pistacia integerrima. Asian Pac. J. Cancer. Prev. 17, 51-55.

Rizwan A, Pieters L, Rahman NU, Riaz M. 2013. Antimicrobial and Antioxidant Activity of Crude Extracts of Two Medicinal Plants Pistacia integerrima and Debregeasia salicifolia. Int. J. Pharm. Sci. Rev. Res 18(1), 03, 13-17.

Saghir MGA, Porter DM. 2011. Taxonomic Revision of the Genus Pistacia L. (Anacardiaceae). American Journal of Plant Sciences 3, 12-32.

Sebiomo Awofodu AD, AwosanyaAO,  Awotona FE, Ajayi AJ. 2011. Comparative studies of the antibacterial effect of some antibiotics and ginger (Zingiber officinale) on two pathogenic bacteria. Journal of Microbiology and Antimicrobials 3, 18-22.

Shah S, Siraj Ud Din, Rehmanullah Jamal Q. 2013.Pharmacological evaluation of Ziziphus nummularia leaves for phytotoxic andmolluscicidal bioassays. African Journal of Pharmacy and Pharmacology 7(45), 2887-2891.

Shamim A, Ali M, Ansari SH. 2011. Phenolic constituents from the galls of Pistacia integerrima Stewart. Indian journal of chemistry 50:115-118.

Shamim A, Mohammed A, Shahid H, Ansari, Faheem A. 2010. Phytoconstituents from the galls of Pistacia integerrima Stewart. Journal of Saudi Chemical Society 14, 409–412.

Sharifullah, Shuaib M, Khan I, Ali S, Ali K, Kumar T. 2016. Study of important medicinal plants of district Dir Upper, Pakistan. Pak. J. Weed Sci. Res 22(4), 595-606.

Sher H, Elyemeni M, Hussain K, Sher H. 2011. Ethnobotanical and economic observations of someplant resources from the northern parts of Pakistan. Ethnobot. Res. App  9, 27-41.

Shirole RL, Shirole NL, Kshatriya AA, Kulkarni R, Saraf MN. 2014. Investigation into the mechanism of action of essential oil of Pistacia integerrima for its antiasthmatic activity. J Ethnopharmacol 153(3), 541-51.

Shuaib M,  Jang N, Ayub S, Rahman SU, Khan MT, Fazil M, Ali Z. 2016.Export of Important Medicinal Plants to Local and International Market from District Dir, Khyber Pakhtunkhwa, Pakistan. American-Eurasian J. Agric. & Environ. Sci 16(1),  99-103.

Shuaib M, Khan I, Sharifullah, Khan MT. 2015.Study of Medicinal Plants of Lower Dir, Timergara, Tehsil Balambat, Khyber Paktunkhaw-Pakistan. American-Eurasian J. Agric. Environ. Sci.  15(10), 2088-2094.

Shuaib M, Khan I, Sharifullah Khan R, Hashmatullah Mubarik S, Naz R. 2014. Ethnobotanical studies of spring flora of Dir Lower, Khyber Pakhtunkhwa, Pakistan. Pak. J. Weed Sci. Res 20(1), 37-49.

Shuaib M. 2016.Ethno-Botanical Uses of Important Weed Species in DIR (Lower), Khyber, Paktunkhaw, Pakistan. American-Eurasian J. Agric. Environ. Sci. 16(2), 262-265.

Singh M, Chaudhry MA, Yadava JNS, Sanyal SC. 1992. J Antimicrobial Chemotherapy 29, 159-68.

Tang WG. 1992. Eisenbrand. J Plant Research 401-415.

Uddin G, Rauf A, Taj urRehman, Qaisar M. 2006. Phytochemical screening of Pistacia chinensis var. integerrima. Middle-East J. Sci. Res 7, 707-711.

Upadhye AS, Rajopadhye AA. 2010. Pharmacognostic and phytochemical evaluation of leaf galls of Kakadshringi used in Indian system of medicine. Journal of Scientific and Industrial Research 69 -70.