Evaluation of serum copeptin and heart-fatty acid binding protein as predictor biomarkers for chronic diabetic kidney disease in Egyptian Patients

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Research Paper 01/05/2019
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Evaluation of serum copeptin and heart-fatty acid binding protein as predictor biomarkers for chronic diabetic kidney disease in Egyptian Patients

Hala M. El-Sebaii, Atef A. Bassyouni, Dina M. Seoudi, Eman M. Abd El Azeem
Int. J. Biosci.14( 5), 515-525, May 2019.
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Chronic diabetic kidney disease and diabetic nephropathy are the leading cause of end-stage kidney disease in developed countries. The objective of this study is to evaluate s-copeptin and heart-fatty acid binding protein (H-FABP) as predictor markers of chronic diabetic kidney disease (CDKD) in type 2 Egyptian diabetic patients. Ninety five volunteers were classified as follows: group I comprised 20 normal subjects, group II consisted of 15 hypertensive patients, group III included 30 type 2 diabetic patients (T2D) with normal renal function, and group IV consisted of 15patients with CDKD treated with renin angiotensin aldosterone system inhibitors and group V comprised15 patients with un-treated CDKD. Serum copeptin, H-FABP, diabetic and renal biomarkers were determined. Highly significant increase in s-copeptin level (p<0.001) in hypertensive, treated CDKD and untreated CDKD group compared to control subjects, while a non-significant change were observed in T2DM group. A moderate increased in H-FABP level was recorded in both treated and untreated CDKD group compared to control subjects. Also, s-creatinine significantly increased in both groups of CDKD. On the other hand, e-GFR, showed highly significant decrease (p<0.001) in CDKD groups, compared to other groups. The diagnostic performance study revealed that, s-copeptin and HFABP showed a less diagnostic value in T2D patient group. In hypertensive patient group s-copeptin showed highest diagnostic information, while H-FABP showed a less accuracy. However in CDKD patient groups, s-creatinine and s-copeptin provided the highest diagnostic value followed by H-FABP according to the area under the curve.Hence, s-copeptin is helpful for the identification of chronic diabetic kidney disease (treated and/or untreated) patients with high risk for a decline in renal function.


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