Evaluation of the anti-inflammatory activity of aqueous extracts from Parquetina nigrescens (Afzel.) Bullock (Apocynaceae)
Paper Details
Evaluation of the anti-inflammatory activity of aqueous extracts from Parquetina nigrescens (Afzel.) Bullock (Apocynaceae)
Abstract
The decoction of the leaves of Parquetina nigrescens (Apocynaceae) is used by Ivorian traditional healers for the treatment of inflammation. Regarding this traditional practice, the present study aimed at evaluating through outa scientific approach the anti-inflammatory activity of the aqueous extracts from Parquetinanigrescens leaves. The extracts were tested according to the model of acute rat paw oedema induced by 1% carrageenan. Several doses of phytomedicines were administered orally to the animal sand ranging as follows: 1600, 2400, 4800 mg/kg. The results obtained with the aqueous extracts of Parquetinanigrescens leaves were firstly compared with those of physiological control (NaCl 0.9%) and thereafter with those of the reference (diclofenac sodium 25 mg/kg). The comparisons were performed at 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 12 hours and 15 hours after injecting carrageenan into rats. The parameters considered for this purpose arethe percentage increase of paw circumference (%AUG) and the percentage inhibition of treatment (%INH). Thus, therewas a significant difference (p<0.001) between the %AUG of phytomedicine treatment at different doses and those of saline (NaCl). However, for a dose of 4800 mg/kg, when administered byoralroute, the AUG of the phytomedicine are statistically the same as those of diclofenac (25 mg/kg). Comparisons of %INH leadto similar results with %AUG. This study, therefore, confirms the anti-inflammatory properties of Parquetina nigrescens leaves and emphasizes the empirical use of that plant species in the treatment of inflammation.
Aké-Assi E, N’guessan K, Kouassi AF. 2015. Evaluation of the acute toxicity of the aqueous extract of the leaves of Thunbergia atacorensis, a new species. European Scientific Journal 11(27), 92-100. https://core.ac.uk/download/pdf/236413487.pdf
Epa C, Elion IRDG, Etou OAW, Attibayéba, Ongoka PR, Abena AA. 2015. Anti-inflammatory and healing effect of aqueous and ethanolic extracts of the trunk bark of Buchholzia coriacea Engl. (Capparidaceae). Journal of Applied Biosciences 94, 8858–8868. https://www.ajol.info/index.php/jab/article/view/127709
Fleurentin J, Hayon JC, Pelt JM. 2007. Plants that heal us-traditions and therapeutics. Editions Ouest-France, 7-14 p.
Heymonet C. 2013. Anti-inflammatory plants used in herbal medicine. Doctorate thesis in Pharmacy, Faculty of Pharmacy, University of Lorraine, 199 p. https://hal.univ-lorraine.fr/hal-01733269
Hoekou YP, Tchacondo T, Gbogbo AK, Agban A, Pissang P, Atakpama W, Karou SD, Batawila K, Akpagana K. 2016. Antimicrobial activities of Parquetina nigrescens (Afzel.) Bullock, a plant used in medicine Togolese tradition in the treatment of microbial infections. Africa Science 12 (5), 182-188. https://www.researchgate.net/publication/
Kouamé YY, Okpekon AT, Yapi HF, Gbassi KG. 2016. Evaluation of anti-inflammatory activities of aqueous and ethanolic extracts of Xylopia villosa (Anonaceae). Asian Journal of Biochemical and Pharmaceutical Research 6(3), 106-112. https://www.researchgate.net/publication/
Laurence P. 2021. Ethnomedicine. Anthropen, The French-speaking dictionary of anthropology anchored in the contemporary, 4 p. https://revues.ulaval.ca/ojs/index.php/anthropen/article/view/51288
N’diaye M, Sy G, Dièye AM, Touré MT, Faye B. 2006. Evaluation of the anti-inflammatory activity of Annona reticulata (annonaceae) leaves on acute induced rat paw edema by carrageenan. Pharm. Med. Trans. Afr. 2006, Vol. XIV: 179-186. https://docplayer.fr/37640171-Evaluation-de-l-activite-anti-inflammatoire-de-feuilles.html
N’Guessan K. 2008. Medicinal plants and traditional medical practices among the Abbey and Krobou peoples of the Agboville Department (Côte d’Ivoire). State Doctorate Thesis in Natural Sciences, Ethnobotany Specialty, University of Cocody-Abidjan (Côte d’Ivoire), UFR Biosciences, Botany Laboratory, 235 p.
Nuhrich A. 2015. Non-steroidal anti-inflammatories. Report from the UFR of Pharmaceutical Sciences of the University of Bordeaux-France, 59 p. http://untori2.crihan.fr/unspf/2015_Bordeaux_Nuhrich_AINS/res/AINS_A_Nuhrich_2015.pdf
Owoyele BV, Nafiu AB., Oyewole IA., Oyewole LA, Soladoye AO. 2009. Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract. Journal of Ethnopharmacology: 122, 86-90. http://dx.doi.org/10.1016/j.jep.2008.11027
Souhel M. 2010. Analysis of the prescription of non-steroidal anti-inflammatories in the reference health center of commune III of the Bamako district. Doctorate thesis in pharmacy. University of Bamako.
Soro TY, Néné-bi AS, Zahoui OS, Yapi A, Traoré F. 2015. Anti-inflammatory activity of the aqueous extract of Ximenia americana (Linnae) (Olacaceae). Journal of Animal & Plant Sciences24(3), 3802-3813. https://www.researchgate.net/publication/279531975
Ta BIH, Aké CB, Konkon NG, N’Guessan K. 2018. Evaluation of the anti-inflammatory activity of aqueous extracts from Corchorus olitorius (Malvaceae). The Pharma Innovation Journal 7(4), 800-802. https://www.thepharmajournal.com/archives/2018/vol7issue4/PartM/7-4-41-596.pdf
Ta BIH.2017. Ethnobotanical, phytochemical and pharmacodynamic studies of some species of the genus Corchorus L., recorded in Côte d’Ivoire. Single Doctoral thesis, UFR Biosciences, Félix Houphouet Boigtny University of Abidjan, 142 p.
Ta BIH, Doh KS, Yéo S, Aké-Assi E, N’Guessan K. 2023.Study of the acute toxicity of aqueous extracts of alchornea cordifolia (euphorbiaceae) and tithonia diversifolia (asteraceae), two plants frequently cited in traditional medicine of Ivory Coast. Rev. Ivory. Sci. Technol. 42, 349-362. https://revist.net/REVIST_42/21-ST-935.pdf
Ta Bi Irié Honoré, Dro Bernadin, Ake Claude Bernard, Ake-Assi Ablan Emma, N’guessan Koffi, University of Man, Côte d’Ivoire, UFR Agronomic Forestry, Environmental Engineering (IAFE), 2024. Evaluation of the anti-inflammatory activity of aqueous extracts from Parquetina nigrescens (Afzel.) Bullock (Apocynaceae). Int. J. Biosci., 24(2), 51-57.
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