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Evaluation of the antimicrobial activity and cytotoxic effect of some uridine derivatives

Research Paper | June 1, 2018

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Sarkar M. A. Kawsar, Mariam Islam, Sanjida Jesmin, Mohammad A. Manchur, Imtiaj Hasan, Sulatana Rajia

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Int. J. Biosci.12( 6), 211-219, June 2018

DOI: http://dx.doi.org/10.12692/ijb/12.6.211-219


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Nucleoside analogues may represent good candidates for the discovery of new antimicrobial agents, therefore, a series of uridine derivatives (2-13) was assessed for their antibacterial and antifungal activities, and the relationship between the structure and activity of these molecules was outlined. The 2-bromobenzoylation of uridine derivatives was evaluated for in vitro antibacterial and antifungal screening studies against a number of human and plant pathogenic microorganisms by disc diffusion and food poisoned methods, respectively. From the antibacterial screening results, it was revealed that the test chemical 4 and 6 very significantly inhibited the growth of all Gram-positive and Gram-negative bacterial strains used. The inhibition of E. coli by 4 (14 mm), of S. typhiby 4 (15 mm), of B. subtilisby 6 (12 mm), of B. cereus by 6 (14 mm) were remarkable. However, the test chemical 10 inhibited the highest mycelial growth of Rhizopus nigricans (60.0%) against all examined fungal pathogens. For comparative studies, two standard antibiotics, Ampicillin and Nystatin, were also determined. In addition to that the toxicity results of brine shrimp lethality assay displayed the test chemicals 6, 7 and 8 highest levels of mortality (i.e., ~80% death) among all tested chemicals. Hence, uridine derivatives bearing various acyl substituents in the ribose moiety may represent good lead compounds for the future discovery of novel antibacterial and/or antifungal agents.


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Evaluation of the antimicrobial activity and cytotoxic effect of some uridine derivatives

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