Evaluation of the specific pharmacological activity of Padus grayana Maxim dry extract on an experimental model of staphylococcal infection in mice
Paper Details
Evaluation of the specific pharmacological activity of Padus grayana Maxim dry extract on an experimental model of staphylococcal infection in mice
Abstract
Padus grayana Maxim belongs to the family Rosaceae and one of the important herbal plants. The extract of the plant is used to treat many diseases. Hence the current study was conducted to investigate the specific pharmacological activity of Padus grayana Maxim. The extract of the plant was obtained from the dried stem, leaves, and flowers of the plant. A series of experiments were conducted to study the effect of the phytoextract on the development of staphylococcal infection in 40 outbred white mice. The results show that prophylactic administration of the dry extract of Padus grayana Maxim to mice at a dose of 200 mg/kg of body weight led to a reduction in mortality by 60% and an improvement of the clinical symptoms of staphylococcal infection in mice. After one week of using the extract of Padus grayana maxim in infected mice, the survival rate of the experimental group was higher than the control group which was 80%, and normalization of hematological parameters of peripheral blood in infected animals was also finding significantly improved. Hence, we concluded that the extract of Padus grayana maxim has significant results in the enhancement of immunity against Staphylococcus.
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