Exploring antifungal activities of Tamarix aphylla and Zygophyllum album extracts against human mucormycosis
Paper Details
Exploring antifungal activities of Tamarix aphylla and Zygophyllum album extracts against human mucormycosis
Abstract
Recent studies concerned with various medicinal plant ingredients which have antimicrobial activities have directed special attention toward the pathogenic microorganisms such as bacteria and fungi. Fungal diseases severity increases in immunosuppressed persons, which impacts the public health. The purpose of this research was to study in vitro antifungal effects of some nontraditional medicinal plants in Saudi Arabia (Tamarix aphylla, Zygophyllum album and Suaeda palaestina) against some pathogenic fungi through extraction of the active ingredients of each plant (phenolics, flavonoids, etc.). The present research was conducted to evaluate antifungal activity of T. aphylla and Z. album leaf extracts against Mucormycosis “black fungus” pathogenic fungi. Leaves of Tamarix aphylla and Zygophyllum album were obtained, rinsed, dried, ground, and extracted using methanol (70%) and distilled water solvents. GC-MS analysis of the essential oil of plant extracts was carried out for antifungal activity assays. he results were aqueous extraction at 500 ppm mean measured at about 10±0.40 mm, while aqueous extraction at 1000 ppm measured about 14 ±0.70 mm; on the other hand, methanollic extraction at 500 ppm was about 16 ±0.80 mm, and methanollic extraction at 1000 ppm detected about 23 ±0.99 mm of of Tamarix aphylla extraction. The inhibitory effect of Zygophyllum album in aqueous extraction at 500 ppm mean measured about 8±0.22 mm, while aqueous extraction at 1000 ppm measured about 18 ±0.60 mm; on the other hand methanollic extraction at 500 ppm was about 10±0.41 mm, and methanollic extraction at 1000 ppm detected about 20±0.56 mm. Obtained results indicated that Tamarix aphylla and Zygophyllum album had nearly similar inhibitory effects, with slightly more patent effect of methanollic extraction at 1000 ppm Zygophyllum album.
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Nagwa T. Elsharawy, Afra Mohammed Baghdadi, Amna A. Saddiq, Ravi Naidu (2024), Exploring antifungal activities of Tamarix aphylla and Zygophyllum album extracts against human mucormycosis; IJB, V24, N5, May, P203-210
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