Exploring pharmacologically significant bioactive compounds of Psoralea corylifolia L.- A review

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Review Paper 12/04/2024
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Exploring pharmacologically significant bioactive compounds of Psoralea corylifolia L.- A review

G. Bhagirath, G. Surendra Reddy, M. D. Mustafa
Int. J. Biomol. & Biomed.18( 2), 11-18, April 2024.
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Psoralea corylifolia, a Chinese medicinal plant belonging to the Fabaceae family, has long been esteemed in various traditional medicine systems. Recent scrutiny into its phytochemistry and pharmacology unveils a treasure trove of secondary metabolites, totaling 63, delineated into six structural categories: flavonoids, meroterpenes, furanocoumarins, coumestans, steroids, and phenolic compounds. Foremost among these compounds is bakuchiol, a meroterpene gaining traction in the cosmetic industry for its noted anti-aging and anti-acne properties. Furanocoumarins like psoralen and isopsoralen exhibit efficacy in treating psoriasis and vitiligo by inducing skin pigmentation. Moreover, the spectrum of bioactivities demonstrated by other secondary metabolites from P. corylifolia is vast, encompassing antibacterial, anti-inflammatory, antioxidant, antidiabetic, anti-obesity, hepatoprotective, estrogenic, osteogenic, and anticancer effects. Looking ahead, the study underscores both challenges and opportunities for advancing research and development in this domain. Key focal points include optimizing extraction and isolation techniques, standardizing and controlling the quality of plant materials and extracts, elucidating mechanisms of action and molecular targets, and assessing the safety and toxicity profiles of secondary metabolites. In conclusion, P. corylifolia emerges as a botanical gem, poised to unlock novel pharmaceutical and cosmetic avenues. Its multifaceted pharmacological potential underscores its significance in contemporary medicine and warrants further exploration and harnessing of its bioactive constituents.


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