Exploring the therapeutic efficacy of plga-ndp: A comprehensive analysis in oecm-1 oral cancer cells
Paper Details
Exploring the therapeutic efficacy of plga-ndp: A comprehensive analysis in oecm-1 oral cancer cells
Abstract
The study investigates therapeutic potential of PLGA-NDP in OECM-1 oral cancer cells. PLGA-NDP presented higher cytotoxicity, lower redox reaction, and higher release activity in relation to nedaplatin alone. With PLGA-NDP treatment the colony formation assay exhibited a substantial minimize in cell survival. PLGA-NDP also moderate MMP-9 release, indicating inhibition of cellular degranulation. The dose-dependent responses and increased efficacy in relation to nedaplatin alone recommend the potential of PLGA-NDP as novel therapy for oral cancer. These results advise that PLGA-NDP nanoparticles may be more efficient alternative to conventional nedaplatin therapy in cancer treatment, which may result in higher efficiency and decline adverse effects.
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Senkuttuvan ILanchit Chenni, Kathiresan Suresh, Azhamuthu Theerthu, Abulkalam Asath Nihal Ahamed, Ravichandran Pugazhendhi, Rajeswari Vasu, 2025. Exploring the therapeutic efficacy of plga-ndp: A comprehensive analysis in oecm-1 oral cancer cells. Int. J. Biosci., 26(4), 198-207.
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