Fecalmicrobiota transplantation in autism spectrumdisorder– anovel treatment approach

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Research Paper 03/03/2024
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Fecalmicrobiota transplantation in autism spectrumdisorder– anovel treatment approach

Karra Geetha, Kandi Sandhya devi, Madhavaneni Shishla, Atchula Sripriya, T. Rama Rao
Int. J. Biosci.24( 3), 23-29, March 2024.
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Abstract

Autism spectrum disorder is one of the pervasive developmental disorders (PDD) category of neurodevelopmental diseases. Microbiota gut brain axis is a complex network and consists of multiple pathways that send signals between microbiota and brain. Autochthonous microbial diversity in the gut microbiota causes a proliferation of bacteria that can create neurotoxins, which at least partially contributes to the autistic illness of these individuals. This paper reviews fecal microbiota transplantation (FMT) procedure which involves obtaining a filtrate of liquid feces from the donor and introducing it to the recipient Gastro-intestinal tract. Delivery techniques for FMT was classified into upper and lower GI routes. Upper GI routes include nasogastric tube, nasoduodenal tube, nasojejunal tube and oral capsules. Lower GI routes include colonoscopy and enemas. Severe adverse effects are not found in the treatment of FMT indicating that FMT is a safe treatment approach for patients with Autism Spectrum Disorder.

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