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Research Paper | September 25, 2022

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Formulation and in-vivo evaluation of theophylline transdermal patch

JA. Avbunudiogba, E. Agbamu, BB. Iwetan, T. Obavwonovwe, AO. Ifie

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Int. J. Biosci.21(3), 215-222, September 2022

DOI: http://dx.doi.org/10.12692/ijb/21.3.215-222

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Abstract

This was an analytical study to evaluate the transdermal patch of theophylline. Theophylline transdermal patch was prepared by solvent casting method using hydroxyl propyl methylcellulose (HPMC) as polymer in a ratio of 1:3 (drug: polymer), propylene glycol as a permeation enhancer and 0.05M sodium hydroxide solution as solvent. Physicochemical analyses such as color, clarity, flexibility, smoothness, thickness, folding endurance, weight uniformity, percentage moisture uptake, percentage moisture loss, flatness and determination of drug content were performed. The in-vivo study was performed using six Wistar rats, 8-10 weeks old weighing 100-180 g, maintained at a temperature of 30.4 ± 1oC and relative humidity of 84% for the study. The patch was removed from the animals and analyzed for drug content using High Performance Liquid Chromatography (HPLC) at 30 min, 1 h and 2 h. The urine of the animals was collected at the same time interval to assay drug content. Mean weight uniformity (mm) was 0.0433 ± 0.0013, mean thickness uniformity (mm) was 0.34 ± 0.018, folding endurance was 198.67 ± 3.09,% moisture loss and uptake was 12.46 ± 2.98 and 2.12 ± 1.92 respectively. Drug content (%) was 105 ± 0.37. Drug concentration in patch after administration ranged from 89.99% to 97.44% for males and 89.74% to 97.14% for females. Urine drug concentration was highest after 2 h (10.71%) for males and 4.08% for females. The results indicate the feasibility of formulating a theophylline transdermal delivery system.

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Formulation and in-vivo evaluation of theophylline transdermal patch

Amandeep S, Alka B. 2016. Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride. Analytical Science and Technology 7(25), 2-13.

Amjad M, Ehtheshamuddin M, Chand SH, Sabreesh M, Asia R, Kumar GS. 2011. Formulation and evaluation of transdermal atenolol. Advance Research in Pharmaceuticals and Biologicals 1(2), 109-119.

Andersson TL, Stehle B, Davidsson B, Hoglund P. 2000. Bioavailability of estradiol from two matrix transdermal delivery systems: Menorest and Climara. Maturitas 34, 57-64.

Arora P, Mukherjee B. 2002. Design, development, physicochemical, and in vitro and in-vivo evaluation of transdermal patches containing diclofenac diethylammonium salt. Journal of Pharmaceutical Sciences 91(9), 2076-2089.

Carpentieri-Rodrigues LN, Zanluchi JM, Grebogi IH. 2007. Percutaneous absorption enhancers: Mechanisms and potential. Brazilian Archives of Biology and Technology 50(6), 949-961

Chien YW. 1987. Development of transdermal drug delivery systems. Drug Development and Industrial Pharmacy 13, 589-651.

Darwhekar G, Jain D, Patidar V. 2011. Formulation and evaluation of transdermal drug delivery system of clopidogrel bisulfate. Asian Journal of Pharmacy and Life Science 1(3), 269-277.

Dhiman S, Singh TG, Rehni AK. 2011. Transdermal patches: A recent approach to new drug delivery system. International Journal of Pharmacy and Pharmaceutical Sciences 3(5), 26-34.

Fernàndez P, Lafuente N, Bermejo AM, López-Rivadulla M, Cruz A. 1996. HPLC determination of Cocaine and Benzoylecgonine in plasma and urine from drug abusers. Journal of Analytical Toxicology 20(4), 224-228.

Firdose S, Prashanth P, Srikalyani V, Madhavi S, Nalluri BN. 2013. Analysis of Rivastigmine in in vitro transdermal permeation studies by RP-HPLC-PDA method. Journal of Chemical and Pharmaceutical Research 5(11), 436-442.

Gaikwad AK. 2013. Transdermal drug delivery system: Formulation aspects and evaluation. Comprehensive Journal of Pharmaceutical Sciences 1(1), 1-10.

Garala KC, Shinde AJ, Shah PH. 2009.  Formulation and in-vitro characterization of monolithic matrix transdermal systems using HPMC/Eudragit S 100 polymer blends. International Journal of Pharmacy and Pharmaceutical Sciences 1(1), 108-120

Jhawat VC, Saint V, Kamboj S, Maggon N. 2013. Transdermal drug delivery systems: approaches and advancements in drug absorption through skin. International Journal of Pharmaceutical Sciences Review and Research 20(1), 47-56.

Johnson ME, Blankschtein D, Langer R. 1997. Evaluation of solute permeation through the stratum corneum: Lateral bilayer diffusion as the primary transport mechanism. Journal of Pharmaceutical Sciences 86(10), 1162-1172.

Katayose S, Kataoka K. 1997. Water soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymers. Bioconjugate Chemistry 8(5), 702-707.

Kawahara K, Tojo K. 2007. Skin irritation in transdermal drug delivery systems: a strategy for its reduction. Pharmaceutical Research 24(2), 399-408.

Kumar SS, Behury B, Sachinkumar P. 2013. Formulation and evaluation of transdermal patch of Stavudine. Dhaka University Journal of Pharmaceutical Sciences 12(1), 63-69.

Latheeshjlal L, Phanitejaswini P, Soujanya Y, Swapna U. 2011. Transdermal drug delivery systems: An overview. International Journal of PharmTech Research 3(4), 2140-2148.

Nirav PM, Kaushal KC. 2011. Method development, validation and stability study for simultaneous estimation of Etofylline and Theophylline by RP-HPLC chromatography in marketed formulation. Journal of Chemical and Pharmaceutical Research 3(3), 597-609.

Patel DM, Kavitha K. 2011. Formulation and evaluation aspect of transdermal drug delivery system. International Journal of Pharmaceutical Sciences Review and Research 6(2), 83-90.

Patel VH, Patel SS, Raj MM, Patel NK, Raj LM. 2014. Development and characterization of matrix-membrane controlled transdermal drug delivery system of Amlodipine Besylate. Indo American Journal of Pharmaceutical Research 4(11), 5306-5313.

Prabhakar D, Sreekanth J, Jayaveera KN. 2013. Transdermal drug delivery patches: A review. Journal of Drug Delivery and Therapeutics 3(4), 213-221.

Prabhu P, Shah S, Gundad S. 2011. Formulation development and investigation of domperidone transdermal patches. International Journal of Pharmaceutical Investigation 1(4), 240-246

Rajendran V, Ruckmani K. 2011. Invivo and Invivo characterization of transdermal delivery of sertraline hydrochloride films. DARU Journal of Pharmaceutical Sciences 19(16), 424-432.

Rios F, Alberola A, Melendez J, Muedra G, Trigo F. 2017. A validated HPLC method for the determination of vanillyl butyl ether in cosmetic preparations. Cosmetics 4(1), 1-5.

Ruela ALM, Figueiredo EC, Perissinato AG, Lima ACZ, Araujo MB, Pereira GR. 2013. In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil. Brazilian Journal of Pharmaceutical Sciences 49(3), 579-588.

Seema A, Nida A, Shiv SB. 2014. Transdermal delivery a preclinical and clinical perspective of drugs delivered via patches. International Journal of Pharmacy and Pharmaceutical Sciences 6(5), 26-38.

Shirisha S, Joshi G, Sahoo SK, Rao YM. 2017. Preparation and evaluation of matrix type transdermal patches of domperidone maleate: in-vitro and ex-vivo characterization. Indian Journal of Pharmaceutical Education and Research 51(4), 517-524.

Soujanya C, Satya B, Reddy M, Manogna K, Prakash P, Ramesh A. 2014. Formulation and in vitro and In-vivo evaluation of transdermal patches of lornoxicam using natural permeation enhancers. International Journal of Pharmacy Pharmaceutical Sciences 6(4), 282-286.

Souto EB, Fangueiro JF, Fernandes AR, Cano A, Sanchez-Lopez E, GarciamL, Severino P, Paganelli MO, Chaud MV, Silva AM. 2022. Physicochemical and Biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery. Heliyon 8, 1-16

Zhan X, Mao Z, Chen S, Wang G. 2015. Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate. Brazilian Journal of Pharmaceutical Sciences 51(2), 373-382.

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