Formulation of Multi-Functional Nanoparticles for Magnetic Tumour Targeting and their Biomedical Applications

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Research Paper 01/09/2020
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Formulation of Multi-Functional Nanoparticles for Magnetic Tumour Targeting and their Biomedical Applications

Sabahat Irfan, Komal Shahzadi, Rubab Yousaf, Fazeela Zaka, Haiqa Masoud, Sania Riasat, Taiyyiabah Basharat, Saira Batool
Int. J. Biosci.17( 3), 74-81, September 2020.
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Magnetic nano-particles have provided with great therapeutic and diagnostic approach to study cancer. These particles have been using to trace the tumor aided by improved drug delivery system. Super-paramagnetic iron oxide nanoparticles (SPIONs) are highly magnetized to the targeted location of action upon contact to external magnetic field and no magnetization is engaged once the magnetic field is detached evading the accumulation. Formulation as well as characterization of red emmition of polymeric nanocapsules (NCs) including superparamagnetic iron oxide nano-particles for magnetic tumour targeting and biomedical imaging not completely described. The aims of this study is to measure the formulation and use of iron oxide nano- particles for magnetic tumour targeting and biomedical imaging. The self- fluorescent oligomers measured be synthesized and chemically conjugated to PLGA which measured and completed by NMR, FT-IR spectroscopy and mass spectrometry. Hydrophobic SPIONs measured be synthesized over thermal decay and their magnetic and heating possessions measured be assessed by SQUID magnetometry and calorimetric measurements. Magnetic nano-capsules (m-NC) measured and organized by single emulsification and solvent vanishing method. This research measured be helpful for evaluation on ability of the developed m-NC for multi-model bioimaging, magnetic- targeted drug delivery and encapsulation of the chemotherapeutic drug measured be the next stage studies.


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