Paper Details

Fragment based homology modeling and simulation based study of endoglin (CD-105) from Homo sapiens

Bijal Shah, Pramodkumar P. Gupta

DOI: https://dx.doi.org/10.12692/ijb/5.12.374-389

Int. J. Biosci. 5(12), 374-389. December, 2014. (PDF)

Abstract:

The structural data elucidates more information and detailed study in structural informatics, Endoglin (CD105), own a multi-dimensional activity results in cure and prophylaxis in many disease and disorder as angiogenesis and a types of cancer. As till date no structural domain or information is available in any of the biological database. Several non-relevant structure are modeled using a homology and automated system, as the identity were relatively below a relevant percentage among the sequence and templates the results has to be discarded. Finally, here we implemented the fragment based homology modeling to model a 3D structure of Endoglin, resulting in a more appropriate fold the protein was studied in dynamic condition by simulating in a solvent body system at 310K using a CHARMM package in VMD-NAMD. The final model was checked by using PROSA and Procheck.