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General features and molecular mechanisms involved in self-renewal, pluripotency, differentiation, reprogramming of stem cells

Motahhareh Tourchi-Roudsari

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Int. J. Biosci.10( 6), 87-100, June 2017

DOI: http://dx.doi.org/10.12692/ijb/10.6.87-100


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Stem cells have identified as biological cells that exist in nearly all multicellular organisms. They are unspecialized which have the ability to self-renew as well as to differentiate into defined cellular subtypes. Moreover, stem cells have ability to return function to damaged cells in the living organism. Moreover, they have the potential to replace or repair damaged cells and or disease tissues to treat a wide spectrum of diseases and injuries. Molecular mechanism that regulate self-renewal and pluripotency is not clear exactly yet. In this review, I will summarize different types of stem cells, some their properties, potency, and applications. Also, in this paper will be focused on currently known molecular mechanism involved in self-renewal, pluripotency, differentiation, and reprogramming of Stem Cells; such as three of signal transduction pathways involving, Transcription factors and their network, cell cycle regulators, microRNA, telomerase enzyme, chromatin, Epigenetic regulators, and chromatin modification in ES cells.


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General features and molecular mechanisms involved in self-renewal, pluripotency, differentiation, reprogramming of stem cells

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