Genetic diversity of SARS-CoV-2 Variants’ spike gene after 4th wave in Cambodia

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Research Paper 01/05/2022
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Genetic diversity of SARS-CoV-2 Variants’ spike gene after 4th wave in Cambodia

Quan Ke Thai, Phuoc Huynh, Vu Nguyen Quoc, Yen Le Thi, Huyen Nguyen Thi Thuong
Int. J. Biosci.20( 5), 95-102, May 2022.
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SARS-CoV-2 caused millions of deaths and hundreds of millions of infections over the world. While many countries and regions were affected strongly by this new virus, Cambodia showed success in limiting the death and infection before going bad in the fourth wave of the pandemic. In order to understand this success, this study examines the genetic diversity of the Spike gene of SARS-CoV-2 variants in Cambodia. The results indicated the high-frequency haplotype and nucleotide diversity in Cambodia, respectively 0.8669 ± 0.0090 and 0.002761 ± 0.001392. In the S gene, 278 nucleotide polymorphisms were recorded, in which mutation A23403G (D614G) accounted for the highest frequency, corresponding to 97.50%. The gene regions coding for the corresponding positions in the protein are NTD, RBD, and Furin S1/S2 cleavage site (FCS), which are the regions where mutations occur. The genetic diversity of Spike gene of SARS-CoV-2 variants really supported the observation of the success in disease control.


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