HCV prevalence in the volunteer blood donors in Peshawar, Khyber Pakhtunkhwa
Paper Details
HCV prevalence in the volunteer blood donors in Peshawar, Khyber Pakhtunkhwa
Abstract
Hepatitis C is one of the most common blood-borne disease causing significant morbidity and mortality globally. About 3% of the world population is infected by this virus. HCV infection is a leading reason for liver cirrhosis and therefore a major source of hepatocellular carcinoma. This study was designed to determine anti-HCV prevalence based on ELISA (Enzyme link immune sorbent assay), among blood donors in Khyber Teaching Hospital (KTH), Peshawar, Khyber-Pakhtunkhwa province of Pakistan. A total of 8634 blood samples were collected during June 2017 to November 2017 in the blood bank of KTH, Peshawar. All samples were tested for anti-HCV antibodies using ELISA. Analysis of all 8634 blood donors indicated that 97 individuals (1.12%) had anti-HCV antibodies in their sera. According to our study the prevalence of HCV infection is even lower (1.12%) than the common HCV prevalence recorded in the case of all previous studies in our subject areas. The decreasing movement of HCV infection indicates the development in health care facilities and awareness among the common population over the past few years.
Ahmed A. 2006. Anti-HCV in healthy voluntary blood donors in district swat. JPMI 20, 187-90.
Alavian SM, Hajarizadeh B, Ahmadzadasl M, Kabir A, Bagheri LK. 2008. Hepatitis B Virus infection in Iran: A systematic review 281-294.
Ali S, Ahmad B, Ali I, Mehmood N. 2013. Frequency of active HCV infection among anti-HCV positive patients in selected districts of Khyber Pakhtunkhwa, Pakistan. Journal of Microbiology and Infectious Diseases 3, 199-202.
Arshad A, Arshad M, Pervaiz R, Farzana JA, Ahmad N D, Ali IS. 2012. Prevalence of active Hepatitis-C infection in the general Population of District Mardan, Khyber Pakhtunkhwa. Pakistan. J Public Health Biol Sci 1, 3-8.
Bangash MH. 2009. Prevalence of hepatitis B and hepatitis C among healthy blood donors at Kurram agency. J Postgraduate Med Inst 23, 140-5.
Bosch FX, Ribes J, Díaz M, Cléries R. 2004. Primary liver cancer: worldwide incidence and trends. Gastroenterology 127, 5-16.
Bostan N, Mahmood T. 2010. An overview about hepatitis C: A devastating virus. Critical reviews in microbiology 36, 91-133.
Butt T, Amin MS. 2008. Seroprevalence of hepatitis B and C infections among young adult males in Pakistan.
Guerra J, Garenne M, Mohamed MK, Fontanet A. 2012. HCV burden of infection in Egypt: results from a nationwide survey. Journal of viral hepatitis 19, 560-567.
Horner SM. 2014. Activation and evasion of antiviral innate immunity by hepatitis C virus. Journal of molecular biology 426, 1198-1209.
Islam MS, Miah MR, Roy PK, Rahman O, Siddique AB, Chowdhury J. 2015 Genotypes of hepatitis C virus infection in Bangladeshi Population Mymensingh Med 24, 143-151.
Karim F, Nasar A, Alam I, Alam I, Hassam S, Gul R. 2016. Incidence of active HCV infection amongst blood donors of Mardan District, Pakistan. Asian Pac J Cancer Prev 17, 235-8.
Karki S, Ghimire P, Tiwari BR, Maharjan A, Rajkarnikar M. 2008. Trends in hepatitis B and hepatitis C seroprevalence among Nepalese blood donors. Jpn J Infect Dis 61, 324-6.
Khan NU, Ali I, Ahmad NU, Iqbal A, Rehman LU, Munir I, Rehman MU, Khan S, Ali S, Siddique L, Swati ZA. 2011. Prevalence of active HCV infection among the blood donors of Khyber Pakhtunkwa and FATA region of Pakistan and evaluation of the screening tests for anti-HCV. Virology journal 8, 154.
Khattak MN, Akhtar S, Mahmud S, Roshan TM. 2008. Factors influencing Hepatitis C virus sero-prevalence among blood donors in north-west Pakistan. Journal of Public Health Policy 29, 207-225.
Kim H, Bose SK, Meyer K, Ray R. 2014. Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis. Journal of Virology 88, 2564-2571.
Lavanchy D. 2009. The global burden of hepatitis C. Liver International 29, 74-81.
Lavanchy D. 2011. Evolving epidemiology of hepatitis C virus. Clinical Microbiology and Infection 17, 107-115.
Messina JP, Humphreys I, Flaxman A, Brown A, Cooke GS, Pybus OG, Barnes E. 2015. Global distribution and prevalence of hepatitis C virus genotypes. Hepatology 61, 77-87.
Mujeeb SA, Pearce MS. 2008. Temporal trends in hepatitis B and C infection in family blood donors from interior Sindh, Pakistan. BMC Infectious Diseases 8, 43.
Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. 2006. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. Journal of Hepatology 45, 529-538.
Qureshi H, Bile KM, Jooma R, Alam SE , Afridi HUR. 2010 Prevalence of hepatitis B and C viral infections in Pakistan 16.
Rockstroh J, Grint D, Boesecke C, Soriano V, Lundgren J, Monforte ADA, Peters L. 2012. Increases in acute hepatitis C (HCV) incidence across Europe: which regions and patient groups are affected. In 11th International Congress on Drug Therapy in HIV Infection (HIV11), Glasgow 11-15.
Saito K, Ait-Goughoulte M, Truscott SM, Meyer K, Blazevic A, Abate G, Ray R. 2008. Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production. Journal of Virology 82, 3320-3328.
Shepard CW, Finelli L, Alter MJ. 2005. Global epidemiology of hepatitis C virus infection. The Lancet Infectious Diseases 5, 558-567.
Sherman M. 2010. Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis. In Seminars in liver disease 30, 003-016.
Simmonds P. 2004. Genetic diversity and evolution of hepatitis C virus–15 years on. Journal of General Virology 85, 3173-3188.
Su Y, Norris JL, Zang C, Peng Z, Wang N. 2013 Incidence of hepatitis C virus infection in patients on hemodialysis: a systematic review and meta-analysis. Hemodial 17, 532-541.
Tunio SA, Bano S, Laghari ZA, Ali W, Shamim H, Afreen U. 2014. Seroprevalence of Hepatitis B and Hepatitis C among blood donors in Hyderabad, Pakistan. Gomal Journal of Medical Sciences 11.
World Health Organization. 2004. World Health Organization global burden of disease for hepatitis C J. of ClinPharmacol 44, 20-9.
Sajid Ali, Nourin Mahmood, Jehan Zeb Afridi, Fazal Jalil, Ihtisham Ul Haq, Izaz Ali, Fazal Jalil, Hamza Hameed, Tanveer Ahmad, Najeeb Ur Rehman, Bashir Ahmad (2018), HCV prevalence in the volunteer blood donors in Peshawar, Khyber Pakhtunkhwa; IJB, V12, N4, April, P421-426
https://innspub.net/hcv-prevalence-in-the-volunteer-blood-donors-in-peshawar-khyber-pakhtunkhwa/
Copyright © 2018
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0