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Health perspectives of licorice (Glycyrrhiza glabra Linne.)

Review Paper | March 1, 2020

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Sana Noreen, Bahisht Rizwan, Aiman Ijaz, Muhammad Imran, Sameen Azhar, Tehreem Nisar

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Int. J. Biosci.16( 3), 558-565, March 2020

DOI: http://dx.doi.org/10.12692/ijb/16.3.558-565


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Licorice (Malthi) has been used for thousands of years worldwide as a medicinal remedy with several pharmacologic properties in antique medicine and as a sweetening agent in food products. It has various health advantages and is used to combat various diseases and symptoms. The main objective of this study is to demonstrate the therapeutic effects and health perspectives of licorice (Glycyrrhiza glabra) for safety. It is a significant source of phytochemicals such as flavonoids, iso-flavonoids, triterpene, saponins and glabridin that exhibits a wide range of biological activities, including hepatoprotective, anticular, anti-inflammatory, antiviral, and anticancer activity. Combined use with licorice derivatives and prescription chemotherapy drugs significantly increases the efficacy of anticancer and decreases the side effects of chemotherapy. In addition, glycirizic acid and glycyrrhetinic acid in licorice have been indicated in drug delivery systems targeted for hepatocellular carcinoma treatment to present liver targeting effects. The licorice extracts controls the inflammation and neurotoxicity that leads to Parkinson’s disease. The results indicates that ethanolic extract of licorice is more active in treatment of diabetes, insulin resistance, reducing obesity and ameliorating hypertension, dyslipidemia and suggest that licorice ethanolic extract are effective in preventing and ameliorating the metabolic syndrome. This review aims to outline the current health outlook and medicinal properties and pathways of extract and gain new perspectives for further research and development in licorice.


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Health perspectives of licorice (Glycyrrhiza glabra Linne.)

Abd-Al-Sattar Sadiq Layl L. 2016. Hepatoprotective effect of Glycyrrhiza glabra L. extracts against carbon tetrachloride-induced acute liver damage in rats. Extracts Against Carbon Tetrachloride-Induced Acute Liver Damage in Rats (June 30, 2016). TJPRC: International Journal of Veterinary Science, Medicine & Research (TJPRC: IJVSMR) Vol, 1, 1-8.

Ahmad SM, Iqbal Azhar NA, Masroor SD. 2017. Pharmacoeconomic evaluations and comparison of licorice (Glycyrrhiza glabra L.) with triaminic DM based therapies for common cold in the city of Karachi: Retrospective burden of Illness, Cost and budget impact analysis. Journal of Pharmacognosy and Phytochemistry 6(1), 258-270.

Ahn JY, Kim S, Jung SE, Ha TY. 2010. Effect of licorice (Glycyrrhiza uralensis Fisch) on amyloid-β-induced neurotoxicity in PC12 cells. Food Science and Biotechnology 19(5), 1391-1395.

Altay V, Karahan F, Öztürk M, Hakeem KR, Ilhan E, Erayman M. 2016. Molecular and ecological investigations on the wild populations of Glycyrrhiza taxa distributed in the East Mediterranean Area of Turkey. Journal of Plant Research, 129(6), 1021-1032.

Anandan C, Nurmatov U, Van Schayck OCP, Sheikh A. 2010. Is the prevalence of asthma declining. Systematic review of Epidemiological Studies. Allergy 65(2), 152-167.

Dastagir G, Rizvi MA. 2016. Glycyrrhiza glabra L. (Liquorice). Pakistan Journal of Pharmaceutical Sciences 29(5).

Farahani R, Sherkat R, Hakemi MG, Eskandari N, Yazdani R. 2014. Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma. Advanced Biomedical Research 3.

Goorani S, Morovvati H, Seydi N, Almasi M, Amiri-Paryan A, Nazari F, Zangeneh A. 2019. Hepatoprotective and cytotoxicity properties of aqueous extract of Glycyrrhiza glabra in Wistar rats fed with high-fat diet. Comparative Clinical Pathology 28(5), 1305-1312.

Haflidadottir S, Jonasson JG, Norland H, Einarsdottir SO, Kleiner DE, Lund SH, Björnsson ES. 2014. Long term follow-up and liver-related death rate in patients with non-alcoholic and alcoholic related fatty liver disease. BMC gastroenterology 14(1), 166.

Hatano T, Eerdunbayaer Cui Y, Kuroda T, Shimozu Y. 2017. Licorice as a resource for pharmacologically active phenolic substances: antioxidant and antimicrobial effects. Biological activities and Action Mechanisms of Licorice Ingredients. 59-75.

Hosseini MS, Samsampour D, Ebrahimi M, Abadía J, Khanahmadi M. 2018. Effect of drought stress on growth parameters, osmolyte contents, antioxidant enzymes and glycyrrhizin synthesis in licorice (Glycyrrhiza glabra L.) grown in the field. Phytochemistry 156, 124-134.

Huang L, Nikolic D, van Breemen RB. 2017. Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 409(30), 6937-6948.

Jain P, Pandey R, Shukla SS. 2015. Natural sources of anti-inflammation. In Inflammation: Natural Resources and Its Applications (pp. 25-133).

Jung JC, Lee YH, Kim SH, Kim KJ, Kim KM, Oh S, Jung YS. 2015. Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease. BMC Complementary and Alternative Medicine 16(1), 19.

Karkanis A, Martins N, Petropoulos SA, Ferreira IC. 2018. Phytochemical composition, health effects, and crop management of liquorice (Glycyrrhiza glabra L.): Α medicinal plant. Food Reviews International 34(2), 182-203.

Kataya HH, Hamza AA, Ramadan GA, Khasawneh MA. 2011. Effect of licorice extract on the complications of diabetes nephropathy in rats. Drug and Chemical Toxicology 34(2), 101-108.

Khambu B, Yan S, Huda N, Liu G, Yin XM. 2018. Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease. Liver Research 2(3), 112-119.

Lawrence T. 2009. The nuclear factor NF-κB pathway in inflammation. Cold Spring Harbor Perspectives In Biology 1(6), a001651.

Lee HK, Yang EJ, Kim JY, Song KS, Seong YH. 2012. Inhibitory effects of glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ (25–35)-induced neurotoxicity in cultured rat cortical neurons. Archives of Pharmacal Research 35(5), 897-904.

Li JY, Cao HY, Liu P, Cheng GH, Sun MY. 2014. Glycyrrhizic acid in the treatment of liver diseases: literature review. BioMed research international 2014.

Li L, Zhu W, Yang J, Liu X, Dong Y. 2019. Rapid quantitative analysis of six flavonoids in licorice by ultra-performance convergence chromatography. Food Science and Technology, (AHEAD).

Luís Â, Domingues F, Pereira L. 2018. Metabolic changes after licorice consumption: A systematic review with meta-analysis and trial sequential analysis of clinical trials. Phytomedicine 39, 17-24.

Namazi N, Alizadeh M, Mirtaheri E, Farajnia S. 2017. The effect of dried Glycyrrhiza glabra L. extract on obesity management with regard to PPAR-γ2 (Pro12Ala) gene polymorphism in obese subjects following an energy restricted diet. Advanced Pharmaceutical Bulletin 7(2), 221.

Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MBP. 2018. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy research 32(12), 2323-2339.

Petramfar P, Hajari F, Yousefi G, Azadi S, Hamedi A. 2020. Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson’s disease, A randomized double blinded clinical trial. Journal of Ethnopharmacology 247, 112226.

Ravanfar P, Namazi G, Atigh M, Zafarmand S, Hamedi A, Salehi A, Borhani-Haghighi A. 2016. Efficacy of whole extract of licorice in neurological improvement of patients after acute ischemic stroke. Journal of Herbal Medicine 6(1), 12-17.

Ravanfar P, Namazi G, Borhani-Haghighi A, Zafarmand S. 2018. Neurologic effects of licorice: A Review. Pharmacognosy Reviews 12(23).

Sasakawa Y, Kominami A, Abe M, Yamamoto K, Nakao M, Nakaoka F, Kunisawa J. 2017. The Anti-obesity and Anti-inflammatory Effects of “LICONINE™”, an Extract of Glycyrrhiza uralensis, on Diet-induced Obese Mice and 3T3-L1 Mouse Adipocytes. Journal of Food and Nutrition Research 5(10), 781-788.

Shamim ARSHIYA, Mahmood T, Mukeem M, Siddiqui HH, Bagga P, Firdaus H, Roy S. 2016. Effect of ethanolic extract of Glycyrizza glabra against streptozotocin and high-fat diet-induced diabetes and hyperlipidemia. International Journal of Pharmacy and Pharmaceutical Sciences 8(4), 259-266.

Srinivasan M, Lahiri DK. 2015. Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis. Expert opinion on therapeutic Targets 19(4), 471-487.

Sun X, Duan X, Wang C, Liu Z, Sun P, Huo X, Meng Q. 2017. Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice. European journal of pharmacology 806, 75-82.

Tester J. Licorice demonstrates hepatoprotective effect in alcohol-induced fatty liver disease. Australian Journal of Herbal Medicine. 2016 Jun 1;28(2), 57-8.

Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, Coggeshall M. 2016. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet 388(10053), 1545-1602.

Wang CY, Kao TC, Lo WH, Yen GC. 2011. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. Journal of Agricultural and Food Chemistry 59(14), 7726-7733.

Wu F, Jin Z, Jin J. 2013. Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. Molecular Medicine Reports 7(4), 1278-1282.

Yang EJ, Park GH, Song KS. 2013. Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells. Neurotoxicology 39, 114-123.

Yang N, Zhang S, Yang S, Guo Z, Zhang X, Zhao Y. 2016. The inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by Ginsenosides from Panax ginseng CA Meyer and simultaneous determination by HPLC-ELSD. Journal of Functional Foods 23, 188-197.

Yehuda I, Madar Z, LeikinFrenkel A, Tamir S. 2015. Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high‐glucose stress and inflammation. Molecular Nutrition & Food Research 59(6), 1041-1052.

Yu JY, Ha JY, Kim KM, Jung YS, Jung JC, Oh S. 2015. Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin in BV2 cells and mice liver. Molecules 20(7), 13041-13054.

Yu XQ, Xue CC, Zhou ZW, Li CG, Du YM, Liang J, Zhou SF. 2008. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (Licorice). Life sciences 82(1-2), 68-78.